A substantiation study for a new conception of blood groups of ABO system on the basis of a complex of laboratory researches, conducted at Sytenko Institute

Authors

  • Yury Delevsky

DOI:

https://doi.org/10.15674/0030-598720131101-103

Keywords:

ABO system, isotype of antigens A and B, nonagglutinating anti-A and anti-B, serum immunosuppression factor, N-acetyl-D-galactosamine-transferas

Abstract

Existence of agglutinogenic (alkaline) and nonagglutinogenic (acid) glycotopes of A and B antigens is substantiated. The two isotypes of antigens have their two corresponding types of transferases with the maximum activity in the pH area, which is opposite to the antigens synthesized. Also, the antigen isotypes have their two corresponding types of antibodies: α-, β-agglutinins and nonagglutinating anti-A, anti-B. The acid isotype of A and B antigens may not correspond to the blood group, thereby substantiating a new differentiation of these groups in ABO system. In case of discrepancy between the agglutinating and sorption (complement-binding) ABO characteristics, the natural immunosuppressive factor is revealed in blood serum.

References

  1. Delevsky Yu. To the discrepancies between group belonging and isoantigenic characteristic of human skin / Yu. Delevsky // Orthopaedics, traumatology and prosthetics. — 1966. — № 9. — P. 17–22.
  2. Delevsky Yu. On the selecting a donor with genetically determined differences in AB0 tissue differentiation / Yu. Delevsky // Orthopaedics, traumatology and prosthetics. — 1971. — № 9. — P. 56–63.
  3. Delevsky Yu. On the dual nature of group antigenic label of blood cells and human tissues / Yu. Delevsky // Annals of USSR Academy of Medical Sciences. — 1975. — № 5. — P. 79–87.
  4. Delevsky Yu. Skin allotransplantation with regard of A, B, C HLA antigens, the phenomenon of ANAP in AB0 system and natural immunosuppressive factor, associated with this system / Yu. Delevsky // Proceedings of the 7th International Conference on tissue typing. — Leningrad. — 1981. — P. 95–97.
  5. Delevsky Yu. To the study of the nature of A1- and A2-antigenic differences by monoclonal antibodies — the role of glycoprotein and glycolipid epitopes in their formation / Yu. Delevsky // Clinical and laboratory diagnostics. — 2006. — № 10. — P. 6–11.
  6. Delevsky Yu. The effect of pH medium on agglutinating ability of anti-A antibodies and their inhibition by A-glycoconjugates of lipid and protein nature with different isoelectric properties / Yu. Delevsky // Clinical and laboratory diagnostics. — 2008. — № 8. — P. 29–32.
  7. Delevsky Yu. The substantiation of isotypic differentiation in ABO system with regard of nonagglutinogenic acid glycotopes of lipid origin / Yu. Delevsky // Annals of Russian Academy of Medical Sciences. — 2008. — №4. — P. 3–10.
  8. Delevsky Yu. The comparison of the antigenic spectrum of A1-, A2- and Ax- erythrocytes — the inhibition of MABs by glycoconjugates of lipid and protein nature with different isoelectric properties / Yu. Delevsky, A. Zinchenko // Clinical and laboratory diagnostics. — 2007. — № 12. — P. 49–53.
  9. Human serum immunosuppressive factor, associated with AB0 system / Yu. Delevsky, A. Gavrilina, M. Ishhanova, L. Havkina // Immunology and Allergology, Rep. Digest. — 13th Issue. — Kiev. — 1979. — P. 49–54.
  10. Delevsky J. Dualität der Antigenmerkmale der Erythrozyten und des Knochengewebes / J. Delevsky // Wissenschaftliche Zeitschrift der Humbold-Universität zu Berlin. — Math. — Nat. R. XXIII. — 1974. — № 2/3. — P. 219–223.
  11. Delevsky Yu. P. Serological and topographic differences in erythrocytic antigenic markers of ABH-glycolipids and glycoprotein / Yu. P. Delevsky // Medicine and ... — 1999. — № 2 (5). — P. 17–23.
  12. Delevsky Yu. P. On the nature of A1 and A2 antigenic differences: the role of glycoprotein and glycolipid agglutinogenic glycotopes in their formation / Yu. P. Delevsky, N. Dimitrova, V. Delevskaya // Медицина и … — 2003. — № 1 (19). — C. 23–28.
  13. Koichiro Kishi. Isoelectric analysis of geneassociated L-galactosyl-transferases in human serum and saliva / Kishi Koichiro, Takizawa Hisao, Iseki Shoei // Proc. Jap. Acad. — 1977. — B–53 (4). — P. 172–177.
  14. Qualitative differences in the enzymes produced by human A1 and A2 genes / H. Schachter, M. A. Michaels, C. A. Tilley et al.: abstract of volunteer papers «AABB-JSBT, International transfusion congress proceedings of the simultaneous sessions». — Washington. — 1972. — P. 16.
  15. Yrothans K. Conditions affecting the performance of the lymphocyte cytotoxicity test / K. Yrothans, K. Rauckman, D. Amos // Transplantation. — 1971. — № 11. — P. 145–150.

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How to Cite

Delevsky, Y. (2013). A substantiation study for a new conception of blood groups of ABO system on the basis of a complex of laboratory researches, conducted at Sytenko Institute. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 101–103. https://doi.org/10.15674/0030-598720131101-103

Issue

No. 1 (2013)

Section

DISCUSSIONS, SEARCH, HYPOTHESES

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Copyright (c) 2014 Yury Delevsky

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