Metabolic state of the bone tissue in patients with false joints of long bones against a background of hyperhomocysteinaemia and associated disturbances
DOI:
https://doi.org/10.15674/0030-59872013132-38Keywords:
false joint, bone tissue, metabolic state, hyperhomocysteinaemia, total cholesterol, interleukin 6Abstract
The purpose of the present research was to study the metabolic state and mineral density of the bone tissue in patients with false joints of long bones and assess their relations with levels of homocysteine, total cholesterol and interleukin 6. Values of mineral density of the bone tissue and levels of homocysteine (HC), total cholesterol (TCS), interleukin 6, transforming growth factor beta 1 (TGF-β1), osteocalcin, cartilage oligomeric matrix protein (COMC), C-terminal propeptide of collagen type I (CICP) and pyridinoline cross-links were examined in 153 patients with false joints of long bones. It was found out that higher levels of HC, TCS and interleukin 6 in blood serum produced a detrimental effect of the structural-functional state of the bone tissue and was accompanied with increased amounts of pyridinoline and COMP, lower levels of osteocalcin, CICP and TGF-β1, as well as mineral density values of the bone tissue. It was proved that increases in blood serum levels of HC, TCS and interleukin 6 were negative determinants for the metabolic state of the bone tissue and associated with inhibition of biosynthetic processes and intensification of destructive ones, as well as with systemic and local loss of the mineral density of the bone tissue. Aberrant levels of HC, TCS and interleukin 6 were predictors of a disturbance in the structural-functional state of the bone tissue in patients with false joints of long bones.References
- Andrushko I. I. Hyperhomocysteinemia as a factor in the pathogenesis of atherosclerosis and coronary heart disease; genesis of proaterogenic action: avtoref. dis. … doctor. med. nauk: 14.01.11 «Cardiology» / I. I. Andrushko. — Kyiv, 2012. — 34 р.
- Bezsmertnyi Y.A. Biochemical indices of rats blood in different terms of reparative osteogenesis at hyperhomocysteinemia / Y. A. Bezsmertnyi // Orthopaedics, Traumatology and Prosthetics. — 2012. —№ 1 (586). — Р. 66–71.
- Bezsmertnyi Y.A. Endothelial secretion of vasoactive molecules in different periods of reparative osteogenesis at hyperhomocysteinemia. / Y. A. Bezsmertnyi // Bukovinsky Medical Journal. — 2012. — Vol. 16, № 2 (62). — Р. 3–6.
- Gololobov V. G. Stem cells and stromal cell osteoblast difference / V. G. Gololobov, R. V. Deev // Morphology. — 2003. — № 1. — Р. 9–19.
- Korzh N. A. Reparative bone regeneration: a modern approach to the problem. Regeneration stage / N. A. Korzh, N. V. Deduh // Orthopedics, Traumatology and Prosthetics. — 2006. — № 1. — Р. 76–84.
- Korzh N. A., Goridova L. D., Romanenko K. K. Reparative bone regeneration: a modern approach to the problem. Local factors affecting the fracture healing. / N. A. Korzh, L. D. Goridova, K. K. Romanenko // Orthopaedics, Traumatology and Prosthetics. — 2006. — № 2. Р. 99–105.
- Korzh N.A. Reparative bone regeneration: a modern approach to the problem. Systemic factors that affect fracture healing / N. A. Korzh, N. V. Deduh, O. A. Nykolchenko // Orthopedics, Traumatology and Prosthetics. — 2006. — № 2. — Р. 93–99.
- Pat. 2371093 RF, MPK A61V6/00, A61V5/107. Method for the diagnosis of osteoporosis by bone nonunion / Kuznetsova O. A., Gyulnazarova S. V.; аpplicant and patent holder FGU «Ural NIITO im. V. D. Chaklin». — № 2008123710/14; stated 06.10.2008.
- Cysteine, homocysteine and bone mineral density: a role for body composition? / A. K. Elshorbagy, C. G. Gjesdal, E. Nurk el al. // Bone. — 2009. — Vol. 44, № 5. — Р. 954–958.
- Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone / M. Herrmann, A. Tami, B. Wildemann et al. // Bone. — 2009. — Vol. 44, № 3. — Р. 467–475.
- L-arginine prevents bone loss and bone collagen breakdown in cyclosporin A–treated rats / C. E. Fiore, P. Pennisi, V. M. Cutuli et al. // Eur J Pharmacol. — 2000. — Vol. 408, № 3. — Р. 323–326.
- The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-beta1, VEGF and BMP-2 in long bone non-unions / C. J. Wang, K. D. Yang, J. Y. Ko et al. // Nitric Oxide. — 2009. — Vol. 20, № 4. — Р. 298–303.
- Yilmaz N. Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis / N. Yilmaz, E. Eren // Aging Clin Exp Res. 2009. — Vol. 21 (4–5). — P. 353–357.
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