Modelling of spondylolisthesis in small laboratory animals

Authors

  • Volodymyr Kutsenko
  • Gennadiy Ivanov
  • Oleksandr Prodan

DOI:

https://doi.org/10.15674/0030-59872011463-68

Keywords:

modelling, spondylolisthesis, roentgenometry

Abstract

The purpose of the present work was to study radio­logical changes in spinal motor segments (SMS) of white rats after degenerative spondylolisthesis had been modelled. The above modelling was carried out in 115 animals by destabilization of the anterior and posterior support complexes of their vertebral column (patent ofUkraine№ 50829). The majority of rats (79.7%) developed antelisthesis by the suggested method. Antelisthesis in young rats developed fast, increasing later gradually and on an average only by 6%. The extent of angle remodelling in young rats was significantly larger. When spondylolisthesis was modelled in rats, SMS deformities (ventrolisthesis, anteflexia, remodelling of the ventrocranial angle of the underlying vertebra) were almost the same as in people in conditions of LV spondylolisthesis (antelis­thesis, anteflexia, remodelling of the anterosuperior angle of SI body) and degenerative spondylolisthesis (remodelling of joint facets).

References

  1. Lesions of the lumbar posterior end-plate in children and adolescents. A. MRI study / T. Ikata, T. Morita, S. Katoh et al. // J. Bone Joint Surg. — 1995. — Vol. 77-B. — P. 951–955.
  2. The pathomechanism of isthmic lumbar spondylolisthesis. A biomechanical study of immature calf spines / K. Sairyo, V.K. Coel, L.J. Grobler et al. // Spine. — 1998. — Vol. 23, № 13. — P. 1442–1446.
  3. Vertebral forward slippage in immature lumbar spine occursfollowing epiphyseal separation and its occurrence is unrelated to disk degeneration in the pediatric spondylolisthesis a physis stress fracture of vertebral body? / K. Sairyo, S. Katoh, T. Sakamaki et al. // Spine. — 2004. — Vol. 29. — P. 524–527.
  4. The pathogenesis of slippage and deformity in the pediatric lumbar spine A radiographic and histological study using a new rat in vivo model / T. Sakamaki, K. Sairyo, S. Katoh et al. // Spine. — 2003. — Vol. 28, № 7. — P. 645–651.
  5. Пат. 50829 U Україна, МПК G09B 23/28. Спосіб моделювання спондилолістезу в експерименті / Продан О.І., Куценко В.О., Іванов Г.В. (UA); заявник та патентовласник ДУ «Інститут патології хребта та суглобів ім. проф. М.І. Ситенка АМН України». — № u200913427; заявл. 23.12.2009; опубл. 25.06.2010, Бюл. № 12.
  6. European convention for protection of vertebrate animals used for experimental and other scientific purpose: Council of Europe. 18.03.1986. — Strasbourg, 1986. — 52 p.
  7. DeWald R.L. Severe spondylolisthesis — introduction / R.L. DeWald // Severe spondylolisthesis: Pathology, Diagnosis, Therapy / Harms J., Sturs H. — Springer, 2003. — P. 1–13.
  8. Harms J. Spondyloptosis and sagittal profile / J. Harms // Severe spondylolisthesis: Pathology, Dianosis, Therapy / Harms J., Sturs H. — Steinkopff-Dartmtadt, 2003. — P. 107–129.
  9. McKinley L.M. The mechanics of severe spondylolisthesis / L.M. McKinley // Severe spondylolisthesis: Pathology, Diagnosis, Therapy / Harms J., Sturs H. — Springer, 2003. — P. 75–91.
  10. Oxland T.R. Biomechanics of the L V–S I junction and the effect of spondylolisthesis and spondyloptosis / T.R. Oxland // Severe spondylolisthesis: Pathology, Diagnosis, Therapy / Harms J., Sturz H. — Springer, 2003. — P.53-67.
  11. Osterman K. Experimental lumbar spondylolisthesis in growing rabbits / K. Osterman, H. Osterman // Clin. Orthop. — 1996. — Vol. 332. — P. 274–280.
  12. The pathomechanism of spondylolitic spondylolisthesis in immature primate lumbar spines in vitro and finite element assessments / R.J. Konx, V.K. Goel, L.J. Grobber et al. // Spine. — 2001. — Vol. 26, № 4. — P. 38–49.
  13. Farfan H.F. The mechanical etiology of spondylolysis and spondylolisthesis / H.F. Farfan, V. Osteria, C. Lamy // Clin. Orthop. — 1976. — Vol. 117, № 1. — P. 40–55.
  14. Информативность дискографии при спондилолистезе по данным патоморфологических исследований / Н.И. Хвисюк, В.В. Фендриков, М.И. Завеля, Н.Н. Сак // Ортопед. травматол. — 1978. — № 11. — С. 18–24.
  15. Pathomechanism of sport-related spondylolisthesis in adolescents: Radiographic and magnetic resonance imaging study / T. Ikata, R. Miyake, S. Katoh et al. // Am. J. Sports Med. — 1996. — Vol. 24. — P. 94–98.
  16. Фендриков В.В. Обоснование и клинико-биомеханическая оценка открытого вправления позвонков при спондилолистезе: автореф. дис. … канд. мед. наук: 14.01.21 / В.В. Фендриков. — Харьков, 1979. — 23 с.
  17. High grade slippage of the lumbar spine in a rat model of spondylolisthesis: Effects of cyclooxygenase-2 inhibitor on its deformity / S. Komatsubara, K. Sairyo, S. Katoh et al. // Spine. — 2006. — Vol. 31. — P. E528–E534.
  18. Куценко В.А. Поясничный спондилолистез (патогенез, диагностика, прогнозирование и лечение): дис. … докт. мед. наук / В.А. Куценко. — Харьков, 2009. — 555 с.

How to Cite

Kutsenko, V., Ivanov, G., & Prodan, O. (2011). Modelling of spondylolisthesis in small laboratory animals. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 63–68. https://doi.org/10.15674/0030-59872011463-68

Issue

Section

ORIGINAL ARTICLES