Clinical-morphological peculiarities of osteoblastomata and their differential diagnosis

Authors

  • Valeriy Hryhorovskyi
  • Anastasiya Hryhorovska

DOI:

https://doi.org/10.15674/0030-59872011417-23

Keywords:

osteoblastoma, clinical-visualizing methods, pathomorphological features, histology diagnosis, differential diagnosis

Abstract

Osteoblastoma (OB) is a rare benign osteogenic tumour formed by interwoven with one another osteal trabeculae, which are surrounded by a lot of osteoblasts. The purpose of the present work was to elucidate the nomenclature and main clinical-visualizing pathohistologic features of OB as a true osteogenic tumor, as well as some aspects of its differential diagnosis with other osteogenic tumors and tumor-like bone lesions. Forty-three cases of biopsies obtained from 39 patients with OB served as the material for this research. The article contains data about clinical-visualizing features of OB (X-ray and CT), its macropathology, histopathology and differential diagnosis, as well as clinical-morphological gradations of osteogenic tumours. It was found out that OB passed clinically as an active or aggressive form with signs of a local destructive growth and inclined to relapsing in case of its incomplete removal, but very seldom it subjected to malignancy. OB often becomes an object of complicated differential-diagnostic solutions, which are possible only with application of both clinical-visualizing and histological methods with priority of the latter ones. The nosological units for differential diagnosis of OB should include the following ones: osteoid-osteoma, ossifying periostitis, chronic osteomyelitis (corticolitis-periostitis), osteoblastoma-like central osteosarcoma with a low grade of malignancy.

References

  1. Баева А.В. Морфологическая диагностика остеобластомы у детей с позиций ранней онкологической патологии / А.В. Баева // Арх. патол. — 1993. — № 3. — С. 62–66.
  2. Виноградова Т.П. Опухоли костей / Т.П. Виноградова. — М.: Медицина, 1973. — 336 с.
  3. Гигантоклеточные пролиферативные поражения костей / В.В. Григоровский, А.П. Крись-Пугач, Р.В. Лучко и соавт. // Ортопед. травматол. — 2001. — № 1. — С. 120–127. — ISSN 0030-5987.
  4. Нейштадт Э.Л. Опухоли и опухолеподобные заболевания костей / Э.Л. Нейштадт, А.Б. Маркочев. — С-Пб.: ФОЛИАНТ. — 2007. — 341 с.
  5. Сак Н.Н. Остеоид-остеома и остеобластома — общность и различие процессов / Н.Н. Сак, В.Ф. Трубников, Е.Я. Панков // Ортопед. травматол. — 1976. — № 12. — С. 38–44. — ISSN 0030-5987.
  6. Osteosarcoma resembling osteoblastoma / F. Bertoni, K.K. Unni, R.A. McLeod, D.C. Dahlin // Cancer. — 1985. — Vol. 55, № 2. — P. 416–426.
  7. Osteoblastoma of the spine / S. Boriani, R. Capanna, D. Donati et al. // Clin. Orthop. Rel. Res. — 1992. — № 278. — P. 37–45.
  8. Brien E.W. Florid reactive periostitis ossificans of the proximal aspect of the tibia: a lesion that must be distinguished from osteosarcoma / E.W. Brien, Ch.A. Zahiri, J.M. Mirra // J. Bone Joint Surg. — 1999. — Vol. 81-A, № 7. — P. 1002–1007.
  9. Dorfman H.D. Bone Tumors / H.D. Dorfman, B. Czerniak. — St. Louis: Mosby, 1998. — 1261 p.
  10. Dorfman H.D. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma / H.D. Dorfman, S.W. Weiss // Semin. Diagn. Pathol. — 1984. — Vol. 1. — P. 215–234.
  11. Franchi A. Immunohistochemical detection of c-fos and c-junexpression in osseous and cartilaginous tumours of the skeleton / A. Franchi, A. Calzolari, G. Zampi // Virchows Arch (B). — 1998. — Vol. 432. — P. 515–519.
  12. Healey J.H. Osteoid Osteoma and Osteoblastoma. Current concepts and recent advances / J.H. Healey, B. Ghelman // Clin. Orthop. — 1986. — № 204. — P. 76–85.
  13. Inwards C.Y. Bone Tumors / C.Y. Inwards, K.K. Unni // Diagnostic Surgical Pathology / S.S. Sternberg. — 3-rd ed. — Philadelphia: Lippincott Williams & Wilkins, 1999. — Vol. 1. — P. 263–315.
  14. Jaffe H.L. Tumors and Tumorous Conditions of the Bones and Joints / H.L. Jaffe. — Philadelphia: Lea and Febiger, 1958. — 629 p.
  15. Osteoblastoma: clinicopathologic study of 306 cases / D.R. Lucas, K.K. Unni, R.A. McLeod et al. // Hum. Pathol. — 1994. — Vol. 25. — P. 117–134.
  16. Malcolm A.J. Osteoblastoma / A.J. Malcolm, A.L. Schiller, R. Schneider-Stock // Pathology and Genetics of Tumours of Soft Tissue and Bone / Ch.D.M. Fletcher, K.K. Unni, F. Mertens. — Lyon: IARCPress, 2002. — P. 262–263.
  17. Merryweather R. Malignant transformation of osteoblastoma / R. Merryweather, J.H. Middlemiss, N.G. Sanerkin // J. Bone Joint Surg. — 1980. — Vol. 62-B, № 3. — P. 381–384.
  18. Mirra J.M. Bone Tumors: Clinical, Radiologic, and Pathologic Correlations / J.M. Mirra. — Philadelphia: Lea & Febiger, 1989. — 1831 p.
  19. Mitchell M.L. Metastatic and pseudomalignant osteoblastoma: a report of two unusual cases / M.L. Mitchell, L.V. Ackerman // Skeletal Radiol. — 1986. — Vol. 15. — P. 213–218.
  20. A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case / J.X. O’Connell, D.J. Rosenthal, H.J. Mankin et al. // J. Bone Joint Surg. — 1993. — Vol. 75-A, № 4. — P. 597–602.
  21. Osteoid-osteoma transforming to aggressive (low grade malignant) osteoblastoma: a case report and literature review / H.S. Pieterse, B. Vernon-Roberts, D.S. Paterson et al. // Histopathology. — 1983. — Vol. 7, № 5. — P. 789–800.
  22. Genetic instability in osteoblastic tumors of the skeletal system / K. Radig, R. Schneider-Stock, U. Mittler et al. // Pathol. Res. And Pract. — 1998. — Vol. 194. — P. 669–677.
  23. Resnick D. Tumors and tumorlike lesions of bone: imaging and pathology of specific lesions / D. Resnick, M. Kyriakos, G.D. Greenway // Diagnosis of bone and joint disorders / D. Resnick. — 3-rd ed. — Philadelphia: Saunders, 1995. — Vol. 6. — P. 3628–3938.
  24. Schajowicz F. Malignant osteoblastoma / F. Schajowicz, C. Lemos // J. Bone Joint Surg. — 1976. — Vol. 58-B, № 2. — P. 202–211.
  25. Schajowicz F. Tumors and Tumorlike Lesions of Bone. Pathology, Radiology and Treatment / F. Schajowicz. — Berlin: Springer, 1994. — 649 p.
  26. Tumors of the Bones and Joints / AFIP Atlas of Tumor Pathology / Unni K.K., Inwards C.Y., Bridge J.A. et al. — 4-th Ser., Fasc. 2 — Silver Spring: ARP Press, 2005. — 399 p.

Downloads

How to Cite

Hryhorovskyi, V., & Hryhorovska, A. (2011). Clinical-morphological peculiarities of osteoblastomata and their differential diagnosis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 17–23. https://doi.org/10.15674/0030-59872011417-23

Issue

No. 4 (2011)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2014 Valeriy Hryhorovsky, Anastasiya Hryhorovska

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).