A comparative analysis of use of tranexamic and aminocapronic acids in surgical treatment of scoliosis

Mykyta Voloshin, Dmytro Petrenko, Andrey Mezentsev

Abstract


The article deals with an acute problem of decrease in blood loss during surgical interventions for scoliotic deformities of the vertebral column. The authors performed a comparative study of use of antifibrinolytic agents in two groups of patients. It was found out that the use of tranexamic acid made it possible to reduce intraoperative blood loss by 17.7 % and demand for haemotransfusion by 35.1 % versus those patients, who took aminocapronic acid.


Keywords


scoliosis; surgery; hemotransfusion

References


Острая нормоволемическая гемодилюция как альтернатива кровосберегающим методикам при операциях коррекции деформаций позвоночника у больных сколиозом III–IV степени / Е.Е. Бирюкова, И.Н. Плетнев, С.Т. Ветрилэ и др. // Вестн. травматол. и ортопед. им. Н.Н. Приорова. — 2001. — № 4. — С. 25–28. — ISSN 0869-8678.

Ройтман Е.В. Применение транексамовой кислоты в педиатрической практике / Е.В. Ройтман // Клиническая фармакология и фармакотерапия. — Москва, 2009. — С. 20–27.

Luban N. Transfusion safety: where we are today? / N. Luban // Annals of the New York Academy of Sciences. — 2005. — Vol. 1054. — P. 325–341.

Transfusion-transmitted cutomegalovirus: lessons from a murine model / J.D. Roback, L. Su, J.C. Zimring, C.D. Hillyer // Transfusion Medicine Review. — 2007. — Vol. 21(1). — P. 26–36.

Трансфузиологические вопросы современной реаниматологии. Часть I. TRALI — трансфузионно-ассоциированное повреждение легких / Л. В. Усенко, А. В.Царев,

В. В. Петров и др. // Медицина неотложных состояний. — 2010. — № 5 (30). — Режим доступа: http://urgent.mif-ua.com/archive/issue-14473/article-14486.

Neilipovitz D.T. Tranexamic acid for major spinal surgery / D.T. Neilipovitz // Eur Spine J. — 2004. — Vol. 13 (Suppl 1). — P. 62–65.

Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children / A. Tzortzopoulou, M.S. Cepeda, R. Shumann, D.B. Carr // Cochrane Database Syst. Rev. — 2008. — Режим доступа: http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006883/frame.html.

Kuklo T. Perioperative blood and blood product management for spinal deformity surgery / T. Kuklo, D.W. Polly Jr. // The spine journal: official journal of the N. Am. Spine Society. — 2003. — Vol. 3. — P. 388–393.

Shapiro F. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for duchenne muscular dystrophy scoliosis / F. Shapiro, D. Zurakowski, N.F. Sethna // Spine. — 2007. — Vol. 32. — P. 2278–2283. — ISSN 0362-2436.




DOI: https://doi.org/10.15674/0030-59872011287-89

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