PREDICTION OF REPEATED OSTEOPOROTIC FRACTURES OF THE THORACIC AND LUMBAR VERTEBRAE (EXPERIMENTAL STUDY)

Authors

DOI:

https://doi.org/10.15674/0030-5987202435-12

Keywords:

Vertebral fractures, repeated compression fracture, predictors, prognosis, prevention, osteoporosis, patterns

Abstract

Objective. To analyze the patterns of occurrence of postoperative recurrent vertebral compression fractures (RVCF) depending on the location of the primary fracture after puncture vertebroplasty. Methods. 520 case histories of patients with osteoporotic fractures of the thoracic and lumbar spine of various locations were analyzed. The total number of treated vertebral bodies was 1,458 (thoracic 596 — 40.88 %, lumbar 862 — 59.12 %). Most often, compression fractures of the spine occurred in the thoracolumbar junction (784 — 53.77 %). RVCF was diagnosed in 64 (12.31 %) people (95 % CI: 9.94–14.68 %) during follow-up examinations, after 1, 3, 6 or 12 months. since the operation. The study was carried out by 3 methods of forecasting: assessment of conditional probabilities, study of the significance of a primary fracture as a predictor of repeated fracture in a specific vertebra, analysis of associative rules and relationships Results. According to the 1st method, all conditional probabilities do not exceed 0.4 and the highest of them are the probabilities LI and LIV RVCF (0.39) with a primary ThVI fracture, and the probability of ThVIII RVCF (0.38) with a ThV primary fracture. Method II found only two regularities that allow an interpretation that corresponds to the purpose of our research. The third method revealed the associative rules and connections of the primary fracture of ThV with RVCF LI, ThXII; according to ThVI with RVCF LI, LII; in the case of ThVIII with RVCF LI, ThXII; ThX fracture with ThX, ThXI, ThXII, LII RVCF; under ThXI conditions with ThV, ThVII, ThVIII, ThIX, ThX, ThXII RVCF; for ThX with RVCF ThIX, ThXI, ThXII, LII; ThX fracture with ThX, ThXI, ThXII, LII RVCF. Conclusions. Prediction of repeated osteoporotic fractures is an important
and topical problem of todayʼs vertebrology. Our study shows the most vivid patterns that are characteristic of the general sample of patients, namely: with a primary fracture of ThXI — a new deformation of ThVIII is possible; in the case of ThVII — new fractures of ThIX, ThXII, LI; for ThXII — injuries of ThXI; primary LI — new ThXII, LIV, LV

Author Biographies

Andrii Popov, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, DSci in Orthopaedics and Traumatology

Mykyta Moloduk, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD

References

  1. Li, Y., Guo, D., Zhang, S., Liang, D., Yuan, K., Mo, G., … Luo, P. (2018). Risk factor analysis for re-collapse of cemented vertebrae after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP). International orthopaedics, 42(9), 2131–2139. https://doi:10.1007/s00264-018-3838-6
  2. An, Z., Chen, C., Wang, J., Zhu, Y., Dong, L., Wei, H., & Wu, L. (2021). Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation. https://doi:10.21203/rs.3.rs-390833/v1
  3. Lee, B. G., Choi, J., Kim, D., Choi, W. R., Lee, S. G., & Kang, C. (2019). Risk factors for newly developed osteoporotic vertebral compression fractures following treatment for osteoporotic vertebral compression fractures. The Spine Journal, 19(2), 301-305. https://doi:10.1016/j.spinee.2018.06.347
  4. Ko, B., Cho, K., & Park, J. (2019). Early adjacent vertebral fractures after balloon Kyphoplasty for Osteoporotic vertebral compression fractures. Asian spine journal, 13(2), 210-215. https://doi:10.31616/asj.2018.0224
  5. Qian, Y., Hu, X., Li, C., Zhao, J., Zhu, Y., Yu, Y., … Cheng, L. (2023). Development of a nomogram model for prediction of new adjacent vertebral compression fractures after vertebroplasty. BMC Surgery, 23(1). https://doi:10.1186/s12893-0
  6. Ma, Y., Lu, Q., Wang, X., Wang, Y., Yuan, F., & Chen, H. (2023). Establishment and validation of a nomogram for predicting new fractures after PKP treatment of for osteoporotic vertebral compression fractures in the elderly individuals. BMC musculoskeletal disorders, 24(1). https://doi:10.1186/s12891-023-06801-3
  7. Dai, C., Liang, G., Zhang, Y., Dong, Y., & Zhou, X. (2022). Risk factors of vertebral re-fracture after PVP or PKP for osteoporotic vertebral compression fractures, especially in eastern Asia: A systematic review and meta-analysis. Journal of orthopaedic surgery and research, 17(1). https://doi:10.1186/s13018-022-03038-z
  8. Li, W., Wang, H., Dong, S., Tang, Z., Chen, L., Cai, X., … Yin, C. (2021). Establishment and validation of a nomogram and web calculator for the risk of new vertebral compression fractures and cement leakage after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures. European spine journal, 31(5), 1108-1121. https://doi:10.1007/s00586-021-07064-z
  9. Gao, Y., Zheng, J., Yao, K., Wang, W., Tan, G., Xin, J., … Chen, Y. (2024). Construction of a nomogram to predict the probability of new vertebral compression fractures after vertebral augmentation of osteoporotic vertebral compression fractures: A retrospective study. Frontiers in medicine, 11. https://doi:10.3389/fmed.2024.1369984
  10. Zheng, J., Gao, Y., Yu, W., Yu, N., Jia, Z., Hao, Y., & Chen, Y. (2023). Development and validation of a nomogram for predicting new vertebral compression fractures after percutaneous kyphoplasty in postmenopausal patients. Journal of orthopaedic surgery and research, 18(1). https://doi:10.1186/s13018-023-04400-5
  11. Li, Q., Long, X., Wang, Y., Fang, X., Guo, D., Lv, J., … Cai, L. (2021). Development and validation of a nomogram for predicting the probability of new vertebral compression fractures after vertebral augmentation of osteoporotic vertebral compression fractures. BMC musculoskeletal disorders, 22(1). https://doi:10.1186/s12891-021-04845-x
  12. Li, W., Wang, H., Dong, S., Tang, Z., Chen, L., Cai, X., … Yin, C. (2021). Establishment and validation of a nomogram and web calculator for the risk of new vertebral compression fractures and cement leakage after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures. European spine journal, 31(5), 1108-1121. https://doi:10.1007/s00586-021-07064-z
  13. Zhang, A., Lin, Y., Kong, M., Chen, J., Gao, W., Fan, J., … Chen, Z. (2023). A nomogram for predicting the risk of new vertebral compression fracture after percutaneous kyphoplasty. European journal of medical research, 28(1). https://doi:10.1186/s40001-023-01235-y

How to Cite

Popov, . A., & Moloduk, M. (2024). PREDICTION OF REPEATED OSTEOPOROTIC FRACTURES OF THE THORACIC AND LUMBAR VERTEBRAE (EXPERIMENTAL STUDY). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 5–12. https://doi.org/10.15674/0030-5987202435-12

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Section

ORIGINAL ARTICLES