THE USE OF LABORATORY CRITERIA IN THE RISK ASSESSMENT OF POSTOPERATIVE COMPLICATIONS AFTER TRANSPEDICULAR FIXATION OF THE LUMBAR SPINE

Authors

  • Oleksandr Barkov Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine https://orcid.org/0000-0003-2161-416X
  • Vladyslav Tuliakov Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine https://orcid.org/0000-0002-3187-1592
  • Valerija Aplevich Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine

DOI:

https://doi.org/10.15674/0030-59872024119-26

Keywords:

Transpedicular fixation, degenerative diseases of the spine, complications, biochemistry, prediction

Abstract

Objective. To investigate the peculiarities of the development of postoperative complications after surgical treatment of degenerative diseases of the lumbar spine with transpedicular fixation of the vertebrae and their relationship with changes in preoperative laboratory parameters. Methods. A retrospective analysis of the biochemical examination data of 35 patients with degenerative diseases of the lumbar spine who underwent discectomy with
transpedicular fixation was performed. In four groups of patients with postoperative complications: 10 patients — inflammation of the what fabrics around metal structures and 5 patients — instability of the metal structure. The results of the examination of 20 people without specified complications served as a comparison group. Comparison was made with a control group (20 practically healthy people). Results. Patients have a significant increase in serum ALT activity by 42.29 and AST by 63.55 %, by 38.37 % of the level of CS content, by 37.21 % of total glycoproteins compared to those in the control group. In patients with soft tissue inflammation around the serum instrument zone, the content of LDLP was recorded by 29.27 %, by 23.53 % of the UA, by 12.34 % of TP results higher by 32.01 % ALT activity and 83 %, 49 % AST, 54.96 % AlP activity, 31.40 % — AlP/AcP, 60.47 % — concentration of CS, 95.57 % — total glycoproteins than in persons in the control group. In the serum of patients with the development of instability of metal structures, 28.55 % was observed by activity of the ALT, AlP — by 38.47 %, AcP — by 48.84 %, less by 58.35 % of AlP/AcP, the CHOL content of 13 88 %, higher by 25.43 % of the LDLP content than such persons in the control group. Content of the P was lower by 31.51 % and the Ca/P ratio was higher by 38.95 %, the content of CS by 83.72 %, total glycoproteins — by 48.83 %. Conclusions. Comparative analysis of the results of preoperative clinical and laboratory examination of patients with degenerative spinal diseases with transpedicular fixation which is reflected in the deviations of their preoperative laboratory parameters from such persons with uncomplicated course of the postoperative period after similar surgery.

Author Biographies

Oleksandr Barkov, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, PhD in Traumatology and Orthopаedics

Vladyslav Tuliakov, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

DSci in Pharmacy

Valerija Aplevich, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, PhD

References

  1. Castillo, H., Chintapalli, R. T., Boyajian, H. H., Cruz, S. A.,
  2. Morgan, V. K., Shi, L. L., & Lee, M. J. (2019). Lumbar discectomy is associated with higher rates of lumbar fusion.
  3. The Spine Journal, 19(3), 487-492. https://doi.org/10.1016/j.
  4. spinee.2018.05.016
  5. Amin, R. M., Andrade, N. S., & Neuman, B. J. (2017). Lumbar
  6. disc Herniation. Current Reviews in Musculoskeletal Medicine, 10(4), 507-516. https://doi.org/10.1007/s12178-017-9441-4
  7. Kang, T. W., Park, S. Y., Oh, H., Lee, S. H., Park, J. H., &
  8. Suh, S. W. (2021). Risk of reoperation and infection after
  9. percutaneous endoscopic lumbar discectomy and open lumbar
  10. discectomy. The Bone & Joint Journal, 103-B(8), 1392-1399.
  11. https://doi.org/10.1302/0301-620x.103b8.bjj-2020-2541.r2
  12. Zhang, Y., Pan, Z., Yu, Y., Zhang, D., Ha, Y., Yi, S., Shin, D. A.,
  13. Sun, J., Koga, H., Phan, K., Azimi, P., Huang, W., & Cao, K.
  14. (2018). The modified transforaminal endoscopic technique in
  15. treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniations. Quantitative Imaging in
  16. Medicine and Surgery, 8(9), 936-945. https://doi.org/10.21037/
  17. qims.2018.10.02
  18. Kim, M., Lee, S., Kim, H., Park, S., Shim, S., & Lim, D.
  19. (2018). A comparison of percutaneous endoscopic lumbar
  20. Discectomy and open lumbar Microdiscectomy for lumbar disc
  21. Herniation in the Korean: A meta-analysis. BioMed Research
  22. International, 2018, 1-8. https://doi.org/10.1155/2018/9073460
  23. Li, Y., Wang, B., Wang, S., Li, P., & Jiang, B. (2019). Full-endoscopic decompression for lumbar lateral recess stenosis via
  24. an interlaminar approach versus a Transforaminal approach.
  25. World Neurosurgery, 128, e632-e638. https://doi.org/10.1016/j.
  26. wneu.2019.04.221
  27. Kizaki, K., Uchida, S., Shanmugaraj, A., Aquino, C. C.,
  28. Duong, A., Simunovic, N., Martin, H. D., & Ayeni, O. R.
  29. (2020). Deep gluteal syndrome is defined as a non-discogenic
  30. sciatic nerve disorder with entrapment in the deep gluteal
  31. space: A systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 28(10), 3354-3364. https://doi.org/10.1007/
  32. s00167-020-05966-x
  33. Gautschi, O. P., Schatlo, B., Schaller, K., & Tessitore, E. (2011).
  34. Clinically relevant complications related to pedicle screw
  35. placement in thoracolumbar surgery and their management:
  36. A literature review of 35,630 pedicle screws. Neurosurgical
  37. Focus, 31(4), E8. https://doi.org/10.3171/2011.7.focus11168
  38. Hijji, F. Y., Narain, A. S., Bohl, D. D., Ahn, J., Long, W. W.,
  39. DiBattista, J. V., Kudaravalli, K. T., & Singh, K. (2017). Lateral
  40. lumbar interbody fusion: A systematic review of complication rates. The Spine Journal, 17(10), 1412-1419. https://doi.
  41. org/10.1016/j.spinee.2017.04.022
  42. Agarwal, A., Schultz, C., Goel, V. K., Agarwal, A., Anand, N.,
  43. Garfin, S. R., & Wang, J. C. (2018). Implant prophylaxis: The next
  44. best practice toward asepsis in spine surgery. Global Spine
  45. Journal, 8(7), 761-765. https://doi.org/10.1177/2192568218762380
  46. Agarwal, A., Schultz, C., Agarwal, A. K., Wang, J. C., Garfin, S. R., & Anand, N. (2018). Harboring contaminants in
  47. repeatedly reprocessed pedicle screws. Global Spine Journal,
  48. (2), 173-178. https://doi.org/10.1177/2192568218784298
  49. Bratschitsch, G., Puchwein, P., Zollner-Schwetz, I., Sadoghi, P.,
  50. Radl, R., Leithner, A., & Leitner, L. (2020). Spinal surgery
  51. site infection leading to implant loosening is influenced by
  52. the number of prior operations. Global Spine Journal, 12(3),
  53. -463. https://doi.org/10.1177/2192568220957268
  54. Patel, Z., Sangani, R., & Lombard, C. (2021). Cement pulmonary embolism after percutaneous kyphoplasty: An unusual
  55. culprit for non–thrombotic pulmonary embolism. Radiology Case Reports, 16(11), 3520-3525. https://doi.org/10.1016/j.
  56. radcr.2021.08.047
  57. Kanno, H. (2021). Answer to the letter to the editor of T.Morimoto
  58. et al. concerning “Novel augmentation technique of percutaneous pedicle screw fixation using hydroxyapatite granules
  59. in the osteoporotic lumbar spine: A cadaveric biomechanical
  60. analysis” by Kanno, et al. [EUR spine J. 2021 jan;30(1):71–78].
  61. European Spine Journal, 31(1), 212-213. https://doi.org/10.1007/
  62. s00586-021-07063-0
  63. Morimoto, T., Kobayashi, T., Hirata, H., Tsukamoto, M.,
  64. Yoshihara, T., Toda, Y., & Mawatari, M. (2023). Cardiopulmonary cement embolism following cement-augmented
  65. pedicle screw fixation: A narrative review. Medicina, 59(2),
  66. https://doi.org/10.3390/medicina59020407
  67. Elbardesy, H., Anazor, F., Mirza, M., Aly, M., & Maatough, A.
  68. (2023). Cemented versus uncemented stems for revision total
  69. hip replacement: A systematic review and meta-analysis.
  70. World Journal of Orthopedics, 14(8), 630-640. https://doi.
  71. org/10.5312/wjo.v14.i8.630
  72. Janssen, I., Ryang, Y., Gempt, J., Bette, S., Gerhardt, J.,
  73. Kirschke, J. S., & Meyer, B. (2017). Risk of cement leakage
  74. and pulmonary embolism by bone cement-augmented pedicle
  75. screw fixation of the thoracolumbar spine. The Spine Journal,
  76. (6), 837-844. https://doi.org/10.1016/j.spinee.2017.01.009
  77. Wu, J., Yuan, Q., Liu, Y., Sun, Y., Zhang, Y., & Tian, W.
  78. (2019). Robot-assisted percutaneous Transfacet screw fixation
  79. supplementing oblique lateral Interbody fusion procedure:
  80. Accuracy and safety evaluation of this novel minimally invasive technique. Orthopaedic Surgery, 11(1), 25-33. https://
  81. doi.org/10.1111/os.12428
  82. Talib, V. H. (2020). Practical Textbook of Laboratory Medicine
  83. nd ed. New Delhi: CBS Publishers and Distributors Pvt Ltd
  84. Morozenko, D. V., & Leontieva, F. S. (2016). Methods
  85. of researching markers of connective tissue metabolism
  86. in clinical and experimental medicine. Young scientist,
  87. (29), 168–172. http://nbuv.gov.ua/UJRN/molv_2016_2_43
  88. (in Ukrainian)
  89. Walters, S. J., Campbell, M. J., & Machin, D. (2021). Medical Statistics: A Textbook for the Health Sciences 5th ed.
  90. Wiley-Blackwellm. https://www.wiley.com/en-us/Medical+Statistics%3A+A+Textbook+for+the+Health+Sciences%2C+5th+Edition-p-9781119423645.
  91. Vorontsov, P. M., Tulyakov, V. O., & Gulida, T. I. (2023).
  92. Changes in calculated indexes of biochemical indicators
  93. of blood serum of rats of different ages after filling a defect
  94. in the metaphysis of the femur with allogeneic bone implants.
  95. Ukrainian journal of medicine, biology and sport, 8(4), 68–73.
  96. http://doi:10.26693/jmbs08/01/068. (in Ukrainian)
  97. Filipenko, V. A., Bondarenko, S. E., Leontyeva, F. S., Tulyakov, V. O., & Vysotsky, O. V. (2023). Changes in indicators of
  98. the coagulation system and markers of inflammation in the
  99. blood of patients with degenerative diseases of large joints
  100. during total arthroplasty. Orthopedics, traumatology and
  101. prosthetics, 4, 20-25. doi: http://dx.doi.org/10.15674/0030-
  102. (in Ukrainian)
  103. Schini, M., Vilaca, T., Gossiel, F., Salam, S., & Eastell, R.
  104. (2022). Bone turnover markers: Basic biology to clinical applications. Endocrine Reviews, 44(3), 417-473. https://doi.
  105. org/10.1210/endrev/bnac031

Downloads

How to Cite

Barkov, O. ., Tuliakov, V. ., & Aplevich, V. . (2024). THE USE OF LABORATORY CRITERIA IN THE RISK ASSESSMENT OF POSTOPERATIVE COMPLICATIONS AFTER TRANSPEDICULAR FIXATION OF THE LUMBAR SPINE. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 19–26. https://doi.org/10.15674/0030-59872024119-26

Issue

No. 1 (2024)

Section

ORIGINAL ARTICLES

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).