Materials based o tricalcium phosphate as bone defects substitute (literature review)


  • Mykola Korzh Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • Volodymyr Filipenko Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • Karolina Poplavska Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • Nataliya Ashukina Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine



Bioceramics, β-tricalcium phosphate, calcium phosphate cement, orthopedic surgeries, bone regeneration


The objective of the study is to determine the current tendencies in the use of osteoplastic materials based on tricalcium phosphate (TCP) in orthopedics and traumatology. Methods. The search of the scientific information for the analysis was carried out in the PubMed, Google Scholar, World Digital Library, ScienceDirect. Results. The development of biomaterials for reconstructive surgery on the skeleton remains an urgent issue of biomaterial engineering, biology and current traumatology and orthopedics. Calcium-phosphate ceramics have the excellent properties of biocompatibility, affinity with bone tissue, biodegradability as well as perfect osteoconductive and osteointegrative properties. They are used in orthopaedics and traumatology as a coating for endoprosthesis components in order to achieve a strong bond with the bone as well as a filling material for bone defects in the form of blocks, granules or powder. The optimal structure of ceramic materials in order to achieve the necessary hardness and control of the dissolution rate is still undetermined. The interest of researchers in the creation of osteoplastic materials containing TCP is explained by the advanced osteoinductive properties and the ability to quickly degrade with the formation of bone tissue. Due to different configurations and sizes of the bone defects, the creation of a material with osteoinductive and osteoconductive properties that could be inserted into the cavity in a liquid state and which would quickly harden and acquire the properties similar to those of the bone has been of great current interest. The material should be biodegradable while having sufficient time for bone formation at the implantation site. In view of the above, the creation of cements based on calcium phosphates has become more attractive. Unfortunately, this material is limited in use due to its brittleness and insufficient hardness. Certain reinforcing additives are expected to significantly improve the mechanical properties of the cement. It is desirable that these particles should have bioactive properties analogous to those of cement. A slight modification of the material can significantly change its properties, which makes it imperative to investigate experimentally the biological properties of the investigated material.

Author Biographies

Mykola Korzh, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, Prof. in Traumatology and Orthopaedics

Volodymyr Filipenko, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, Prof. in Traumatology and Orthopаedics

Karolina Poplavska, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv


Nataliya Ashukina, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

PhD in Biol. Sci


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