The modern approach to treatment of malignant bone tumours (Part 1) (Review of literature)

Authors

  • Oleg Vyrva

DOI:

https://doi.org/10.15674/0030-598720134116-121

Keywords:

bone tumors, treatments, chemotherapy

Abstract

The first part of this review of medical literature about the modern state of the problem of treatment of bone tumours shows that these neoplasms belong to the least studied group with significant positive changes in their treatment during past years. Early detection of pathological foci prevents malignant transformation of benign tumours and tumour-like diseases. Use of up-to-date techniques of examination and modern protocols of multimodality therapy for malignant tumours provides positive long-term results. Individual multimodality therapy of malignant tumours of bones includes neoadjuvant and adjuvant polychemotherapy (PCT), radiation therapy, immunotherapy, plastic surgery, vascular interventions and other methods with compulsory pathomorphological verification of the disease and continuous monitoring for correction of the proper therapy. The concrete clinical situation having been assessed, the method of treatment is agreed by the oncoorthopaedist, oncologist, radiologist, chemotherapeutist and rehabilitation therapist, whose cooperation contributes to creation of the optimum plan of treatment. The chief aim of management of the patient with a malignant bone tumour must consist in effective organ-salvation treatment, the latter being given with observation of principles of ablastics. It is shown that organ-salvation operations are regarded today as the best method of treatment for thoroughly selected patients with osteosarcomata. Amputation is made when it is impossible to remove the primary tumour because of technical problems or a severe, life-endangering state of the patient, a significant dissemination of tumour elements, pathological fractures or a dangerous introduction of major neurovascular formations into the tumour.

References

  1. Cancer prevalence in European registry areas / A. Micheli, I. Mugno, Y. Krogh et al. // Ann Oncol. — 2002. — Vol. 13. — Р. 840–865.
  2. Cancer statistics / A. Jemal, R. Siegel, E. Ward et al. // Cancer J. Clin. — 2007. — Vol. 57. — Р. 43–66.
  3. Babosha V. A. Chemotherapy influence to immune status and metabolic process for malignant bone tumors patients / V. A. Babosha, Feras Anabtavi, L. I. Donchenko // Archive klynycheskoy i eksperymentalnoy medicine. — 2001. — Т. 1, № 3. — P. 67–70.
  4. Preoperative staging, prognostic factors, and outcome for extremity rhabdomyosarcoma: a preliminary report from the Intergroup Rhabdomyosarcoma Study IV (1991–1997) / H. L. Neville, R. J. Andrassy, Т. Е. Lobe et al. // J. Pediatr Surg. — 2000. — Vol. 35. — Р. 317–321.
  5. Patient preparation algorithm for total hip arthroplasthy / S. N. Perehodov, J. S. Volodin, H. G. Ismailov, E. B. Zhiburt // Endoprotezyrovanye in Russia: Vseros. monotem. sbornuhk naychnuh statey. — Kazan- StP., 2008. — P. 30–35.
  6. Experience of preserve surgeries for blood vessels involved bone tumors of extremyties / M. D. Aliev, V. A. Sobolevsky, B. I. Dolgushin, S. I. Tkachev // Voprose oncology. — 2000. — № 1. — P. 80.
  7. Vyrva O. E. Surgical treatment of hand bone tumors and lesions tumor / О. E. Vyrva, L. D. Goridova, Ya. A. Golovina // Orthopedics, traumatology and prosthetics. — 2005. — № 4. — P. 84–89.
  8. Kovaliov D. V. Bone preserving surgeries at the modern time for children long bone sarcomas / D. V. Kovaliov // Vestnic traumatologii and orthopedii im. N. N. Priorov. — 2000. — № 2. — P. 76–79.
  9. Soft tissue sarcoma of the extremities. A multimodality diagnostic and therapeutic approach / S. J. Ham, W. T. van der Graaf, F. Pras et al. // Cancer Treat Rev. — 1998. — Vol. 24. — Р. 373–391.
  10. Save operation in the complex treatment of patients with tumors of the musculoskeletal / V. A. Neverov, V. A. Shilnikov, I. P. Sobolev et al: аbstract book of 1st international symposium plastic and reconstructive surgery in oncology, (Moscow, Russia, March 19–21, 1997). — М. — 1997. — P. 87.
  11. Quality of life and psychosocial adjustment of young patients after treatment of bone cancer / R. Felder-Puig, A. K. Formann, A. Mildner et al. // Cancer. — 1998. — № 83. — Р. 69–75.
  12. Quality of life assessment of patients with extremity sarcoma / P. H. Sugarbaker, I. Barofski, S. A. Rosenberg et al. // Surgery. — 1987. — Vol. 91. — P. 17–23.
  13. Quality of life in bone tumor patients comparing limb salvage and amputation of the lower extremity / A. Postma, A. Kingma, J. H. De Ruiter et al. // J. Surg Oncol. — 1992. — Vol. 51. — Р. 47–51.
  14. Springfield D. S. Introduction to limb-salvage Surgery for sarcomas / D. S. Springfield // Orthop. Clin. North. Am. — 1991. — Vol. 22. — Р. 1–5.
  15. Functional outcome in amputation versus limb sparing of patients with lower extremity sarcoma: a matched case-control study / A. M. Davis, M. Devlin, A. M. Griffin et al. // Arch. Phys. Med. Rehabil. — 1999. — Vol. 80. — Р. 615–618.
  16. Prognosis of lymph node metastasis in soft tissue sarcoma / K. A. Behranwala, R. A’llern, A. M.Omar, J. M. Thomas // Ann. Surg. Oncol. — 2004. — Vol. 11. — Р. 714–719.
  17. Pulmonary metastases from soft tissue sarcoma: analysis of patterns of diseases and poslmelasta-sis survival / K. G. Billingsley, M. E. Burl, E. Jara et al. // Ann Surg. — 1999. — Vol. 229. — Р. 602–610.
  18. Hsu R. W. Management of aggressive benign and malignant bone tumors of the shoulder region / R. W. Hsu, H. N. Shih, K. Y. Hsu // Changgeng Yi Xue Za Zhi. — 1999. — Vol. 22 (1). — Р. 52–60.
  19. Grimmer R. J. Surgical outcomes in osteosarcoma / R. J. Grimmer, A. M. Taminiau, S. R. Cannon // Bone Joint Surg Br. — 2002. — Vol. 84. — Р. 395–400.
  20. Primary malignant tumors of the upper extremity: retrospective analysis of one hundred twenty-six cases / J. J. Creighton Jr, C. A. Peimer, E. R. Mindell et al. // J. Hand Surg Am. — 1985. — Vol. 10. — Р. 805–814.
  21. Ariel I. M. Incidence of metastases to lymph nodes from soft-tissue sarcoma / I. M. Ariel // Semin Surge Oncol. — 1988. — № 4. — Р. 27–29.
  22. Gamma-probe-guided lymph node localization in malignant melanoma / J. C. Alex, D. L. Weaver, J. T. Fairbank et al. // Surg. Oncol. — 1993. — Vol. 2. — Р. 303–308.
  23. Gebhardt M. C. What’s new in musculoskeletal oncology? / M. C. Gebhardt // J. Bone Joint Surg. — 2002. — Vol. 84–A. — P. 694–701.
  24. Grimer R. J. Surgical options for children with osteosarcoma / R. J. Grimer // Lancet Oncol. — 2005. — № 6. — Р. 85–92.
  25. Tunn P. U. Ablative procedures in surgical treatment of malignant bone tumors // P. U. Tunn, H. Delbruck, P. M. Schlag // Orthop. — 2003. — Vol. 32, № 11. — Р. 955–964.
  26. Funovics P. T. Upper-extremity amputation in tumours of the shoulder and upper arm-experiences of the Vienna Bone Tumour Registry / P. T. Funovics, M. Dominkus, R. Kotz // Handchir Mikrochir Plast Chir. — 2008. — Vol. 40 (1). — Р. 13–18.
  27. Patterns of care and survival for patients aged under 40 years with bone sarcoma in Britain, 1980–1994 / C. A. Stiller, S. J. Passmore, M. E. Kroll et al. // Br. J. Cancer. — 2006. — Vol. 94. — Р. 22–29.
  28. Patterns of recurrence in patients with high-grade soft-tissue sarcomas / D. A. Potter, J. Glenn, T. Kinsella et al. // Clin. Oncol. — 1985. — Vol. 3. — Р. 353–366.
  29. Staging soft tissue sarcoma: evolution and change / D. Kotilingam, D. C. Lev, A. J. Lazar, R. E. Pollock // CA Cancer J. Clin. — 2006. — Vol. 56. — Р. 282–291.
  30. Vyrva O. E. Bone substitution after malignant tumors resections of upper limbs / О. E. Vyrva, Ya. А. Golovina, V. V. Burlaka: Modern technology of diagnostics, treatment and rehabilitation of upper limbs disorders: I International Congress: abstracts book — М., 2007. — P.25–26.
  31. Zatsepin S. Т. Long term results of total humer replacement after tumor resection / S. Т. Zatsepin, V. N. Burdigin // Orthopedics, traumatology and prosthetics. — 1993. — № 1. — P. 14–16.
  32. Pashkov U. V. Pediatric bone sarcomas / U. V. Pashkov, N. М. Ivanova, I. V. Glekov // Voprose oncology. — 1995. — Vol. 41, № 2. — P. 75–78.
  33. Malignant tumors of the upper extremity in children / S. H. Kuschner, L. R. Menendez, S. Stephens, H. Gellman // Orthop. Rev. — 1990. — Vol. 19 (5). — Р. 411–417.
  34. Schurovsky О. М. Endoprosthesis replacement for complex treatment of primary pediatric malignant bone tumors / О. M. Schurovsky // Orthopedics, traumatology and prosthetics — 2001. — № 2 — P. 48–51.
  35. Blazer D. G. 3rd. Is there a role for sentinel lymph node biopsy in the management of sarcoma? / D. G. Blazer 3rd, M. S. Sabel, V. K. Sondak // Surg. Oncol. — 2003. — Vol. 12. — Р. 201–206.
  36. Experience with bipolar prosthesis in femoral neck fractures in the elderly and debilitated / P. Gallinaro, G. Tabasso, R. Negretto et al. // Clin. Orthop. — 1993. — Vol. 251. — Р. 26–30.
  37. Modular endoprosthetic replacement for tumours of the proximal femur / C. R. Chandrasekar, R. J. Grimer, S. R. Carter et al. // J. Bone Joint Surg. — 2009. — Vol. 91-В, № 1. — Р. 108–112.
  38. Modular megaprosthesis for proximal femoral tumors / I. Ilyas, R. Pant, A. Kurar et al. // Int. Orthop. — 2002. — Vol. 26. — Р. 170–173.
  39. Lewis M. M. The use of an expandable and adjustable prosthesis in the treatment of childhood malignant bone lumors of the extremity / M. M. Lewis // Cancer. — 1986. — Vol. 57. — Р. 499–502.
  40. Lewis V. O. What’s new in musculoskeletal oncology? / V. O. Lewis // J. Bone Joint Surg. — 2007. — Vol. 89-А, № 6. — P. 1399–1407.
  41. Коtz R. Modern methods of malignant bone tumors treatments: lection. / R. Коtz // Vestnic traumatologii and orthopedii im. N. N. Priorov. — 1994. — № 4. — P. 62–68.
  42. Early healing of implants follows different mechanisms for trabecular and cortical bone / W. J. A. Dhert, E. Duyn, A. J. Verbout et al. // J. Bone Joint Surg. — 1997. — Vol. 79-B, (suppl. I.) — P. 6–7.
  43. Trapeznikov N. N. Statistics malignancies in Russia and some other CIS countries in 1996 / N. N. Trapeznikov, Е. М. Aksel, V. V. Dvoirin // М.: RONCRAMC, 1996. — P. 176.
  44. Malawer M. M. Prosthetic survival and clinical results with use of large-segment replacements in the treatment of high-grade bone sarcomas / M. M. Malawer, В. Chou // J. Bone Joint Surg. — 1995. — Vol. 77-А. — Р. 1154–1165.
  45. Malawer M. Surgical technique and results of limb sparing surgery for high grade bone sarcomas of the knee and shoulder / M. Malawer // Orthopedics. — 1985. — Vol. 8 (5). — P. 597–607.
  46. Local recurrence and local control of non–metastatic osteosarcoma of the extremities: a 27-year experience in a single institution / G. Bacci, C. Forni, A. Longhi et al. // J. Surg. Oncol. — 2007. — Vol. 96, № 2. — P. 118–123.
  47. Babosha V. А. Orthopaedic treatment of limbs bone tumors / V. А. Babosha // Тrauma. — 2004. — Vol. 5, № 2. — P. 224–234.
  48. Ettinger R. S. Cancer in adolescents and young adults. Psychosocial concerns, coping strategies and interventions / R. S. Ettinger, S. P. Heiney // Cancer. — 1993. — Vol. 71. — Р. 3276–3280.
  49. Modular endoprosthetic reconstruction in malignant bone tumors: indications and limits / M. Balke, H. Ahrens, A. Streitbürger et al. // Treatment of bone and soft tissue sarcomas. recent results in cancer research. — B.-Heidelberg-Springer-Verlag, 2009. — Р. 39–50.
  50. Bogdaev U. M. Functional outcoms of surgical treatment of bone tumors around knee / U. М. Bogdaev, А. G. Zhukovets, I. S. Prudivus // Onkohyrurhyya. — 2008. — № 1.– P. 96.
  51. Clinical patterns of metastasis / S. P. Leong, B. Сady, D. M. Jablons et al. // Cancer Metastasis Rev. — 2006. — Vol. 25. — Р. 221–232.
  52. Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma / M. A. Gadd, E. S. Casper, J. M. Woodrul et al. // Ann. Surg. — 1993. — Vol. 218. — Р. 705–712.
  53. Progress and future of methods development of bone tumors / N. N. Тrapeznikov, U. N. Soloviov, N. Е. Kushlinsky et al. // Russian oncology journal — 1998. — № 3. — P. 21–25.
  54. Osteosarcoma / P. J. Messerschmitt, R. M. Garcia, F. W. Abdul-Karim et al. // J. Am. Acad. Orthop. Surg. — 2009. — Vol. 17, № 8. — P. 515–527.
  55. Osteosarcoma in children: long-term functional analysis / P. U. Tunn, P. Schmidt-Peter, D. Pomraenke, P. Hohenberger // Int. Orthop. Rеlat. Res. — 2004. — Vol. 421. — Р. 212–217.
  56. Osteosarcoma treatment of limbs between centuries. 50-years experience / N. N. Тrapeznikov, М. D. Аliev, G. N. Machak et al. // Vestnik RAMC. — 2001. — № 9. — P. 46–49.

Downloads

How to Cite

Vyrva, O. (2014). The modern approach to treatment of malignant bone tumours (Part 1) (Review of literature). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 116–121. https://doi.org/10.15674/0030-598720134116-121

Issue

No. 4 (2013)

Section

DIGESTS AND REVIEWS

License

Copyright (c) 2014 Oleg Vyrva

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).