New resources in combined therapy of osteoarthrosis

Authors

  • Yevgeny Suschuk

DOI:

https://doi.org/10.15674/0030-59872013291-92

Keywords:

osteoarthritis, pain syndrome, glucosamine sulfate, diclofenac spray, aescin gel

Abstract

The effect of the combination therapy of glucosamine sulfate in combination with diclofenac or escin on the intensity of pain in osteoarthritis. A total of 4931 patients entered a mean age of (57 ± 12,97) years. Used treatment which comprises administering intramuscular glucosamine sulfate (400 mg 3 times a week) for four weeks per os (1500 mg 1 time per day) for 8 weeks, and the application of diclofenac (spray 1% 3-4 times daily for 2 weeks) or escin gel locally 2-3 times a day for 8 weeks in the affected joints. Pain intensity was assessed using a numerical rating scale. Found that in the case of both treatments is significantly reduced levels of pain in patients with osteoarthritis of the end of the study (p <0,001). Safety of the combination therapy was high.

References

  1. Felson D. T. Pain in Osteoarthritis / D. T. Felson, Hans-Georg Schaible. — Wiley-Blackwell, 2009 — 308 p.
  2. Effect of combination therapy using the original glucosamine sulfate on pain in patients with osteoarthritis: a prospective study postmarke tingovyh. / O. Borisenko, DA Belenky // Clinical Medicine. — 2013. — № 5. — С. 65–71
  3. Derry S. Topical NSAIDs for chronic musculoskeletal pain in adults / S. Derry, R. A. Moore, R. Rabbie // Cochrane Database Syst. Rev. — 2012. — Vol. 12 (9). — CD007400.
  4. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator / G. Herrero-Beaumont, J. A. Ivorra, M. Del Carmen Trabado et al. // Arthritis Rheum. — 2007. — Vol. 56 (2). — P. 555–567.
  5. Glucosamine therapy for treating osteoarthritis / T. E. Towheed, L. Maxwell, T. P. Anastassiades et al. // Cochrane Database Syst. Rev. — 2005. — Vol. 18 (2). — CD002946.
  6. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial / J. Y. Reginster, R. Deroisy, L. C. Rovati et al. // Lancet. — 2001. — Vol. 357 (9252). — P. 251–256.
  7. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study / K. Pavelká, J. Gatterová, M. Oleja¬rová // Arch. Intern. Med. — 2002. — Vol. 162 (18). — P. 2113–2123.
  8. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials / O. Bruyere, K. Pavelka, L. C. Rovati et al. // Osteoarthritis Cartilage. — 2008. — Vol. 16 (2). — P. 254–260.

Downloads

How to Cite

Suschuk, Y. (2013). New resources in combined therapy of osteoarthrosis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 91–92. https://doi.org/10.15674/0030-59872013291-92

Issue

No. 2 (2013)

Section

SHORT REPORTS AND NEWS FROM PRACTICE

License

Copyright (c) 2014 Yevgeny Suschuk

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).