New resources in combined therapy of osteoarthrosis

Yevgeny Suschuk


The effect of the combination therapy of glucosamine sulfate in combination with diclofenac or escin on the intensity of pain in osteoarthritis. A total of 4931 patients entered a mean age of (57 ± 12,97) years. Used treatment which comprises administering intramuscular glucosamine sulfate (400 mg 3 times a week) for four weeks per os (1500 mg 1 time per day) for 8 weeks, and the application of diclofenac (spray 1% 3-4 times daily for 2 weeks) or escin gel locally 2-3 times a day for 8 weeks in the affected joints. Pain intensity was assessed using a numerical rating scale. Found that in the case of both treatments is significantly reduced levels of pain in patients with osteoarthritis of the end of the study (p <0,001). Safety of the combination therapy was high.


osteoarthritis; pain syndrome; glucosamine sulfate; diclofenac spray; aescin gel


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