Efficacy of Valusal drug in treating patients with degenerative-dystrophic damages of joints

Authors

  • Oleksandr Buryanov
  • Taras Omelchenko
  • Yuriy Sobolevskiy

DOI:

https://doi.org/10.15674/0030-59872012227-34

Keywords:

osteporosis, early stages, non-steroidal anti-inflammatory drugs, efficacy

Abstract

In order to assess clinical efficacy of an integrated use of Valusal drug manufactured by joint-stock company «Grindeks» for treating patients with degenerative-dystrophic diseases of joints during the period of exacerbation with moderately expressed reactive synovitis and pain syndrome, 70 patients underwent multimodality treatment and examination. The results of the above study demonstrated preference of a combination of non-steroidal anti-inflammatory drugs (NSAIDs) in the form of a systemic use of Meloxicam and Ketoprofen local gel Valusal in combination with such a chondroprotective drug as glucosamine sulfate for treating exacerbations and reactive synovitis in patients with early stages of osteoarthritis for safety and speed of achievement of a clinical effect. If there was no need to increase the dose of the systemic NSAID, the clinical efficacy of treatment in the study group was reliably better by the speed of pain relief, reduction of painfulness and oedema, as well as by an increased functional activity of the patients.

References

  1. Остеоартроз : генезис, діагностика, лікування / О. А. Бур’янов, Т. М. Омельченко, О. Е. Міхневич та ін. — К.: Ленвіт, 2009. — 203 с.
  2. Вплив хондроїтину сульфату на процес ліпопероксидації при лікуванні експериментального післятравматичного остеоартрозу / О. А. Бур’янов, І. С. Чекман, Т. М. Омельченко та ін. // Ортопед. травматол. — 2007. — № 2. — С. 56–61.
  3. Виноградова Е. В. Механизмы деструкции и регенерации хряща коленного сустава при остеоартрозе / Е. В. Виноградова // Ортопед. травматол. — 2000. — № 2. — С. 97.
  4. Остеоартроз. Консервативная терапия / Н. А. Корж, Н. В. Дедух, И. А. Зупанец. — Х.: Золотые страницы, 2007. — 424 с.
  5. Buckwalter J. A. Articular cartilage and osteoarthritis / J. A. Buckwalter, H. J. Mankin, A. J Grodzinsky // Instr. Course Lect. — 2005. — Vol. 54. — P. 465–480.
  6. Ciremor P. Osteoarthritis / P. Ciremor // Curr Opion Rheumatol. — 2000. — Vol. 12. — P. 450–455.
  7. Cooper C. Topical NSAIDs in osteoarthritis / C. Cooper, K. M. Jordan // BMJ. — 2004. — Vol. 329, № 7461. — P. 304–305.
  8. Leeb В. A metaanalisis of chondroitinsulfate in the treatment of Osteoarthritis / В. Leeb, K. Montag // J. Rheumatol. — 2000. — Vol. 27, № 1. — P. 205–211.
  9. Mazieres В. Chondroitin sulfate in osteoarthritis knee: a prospective, double-blind, placebo-controlled multicenter clinical stady / В. Mazieres, B. Combe // J. Rheumatol. — 2001. — Vol. 28. — P. 173–181.
  10. McAlindon Т. Glucosamin and Chondroitin for treatment of osteoarthritis: a systematic quality assessment and metaanalysis / Т. McAlindon, M. LaValley // JAMA. — 2000. — Vol. 283. — P. 1469–1475.
  11. Long-term effects of glu-cosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled clinical trial / J. Y. Reginster, R. Deroisy, L. C. Rovati et al. // Lancet. — 2001. — Vol. 357. — Р. 251–256.

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How to Cite

Buryanov, O., Omelchenko, T., & Sobolevskiy, Y. (2012). Efficacy of Valusal drug in treating patients with degenerative-dystrophic damages of joints. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 27–34. https://doi.org/10.15674/0030-59872012227-34

Issue

No. 2 (2012)

Section

ORIGINAL ARTICLES

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Copyright (c) 2014 Oleksandr Buryanov, Taras Omelchenko, Yuriy Sobolevskiy

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