Using of modern patterns of intraoperative fluid resuscitation in orthopedic oncology


  • Kseniia Lyzogub
  • Sergii Kursov
  • Mykola Lyzogub



fluid resus¬citation, restrictive regimen, targeted liquid therapy, central he-modynamics, oxygen consumption, combined anesthesia


Objective: to study the changes in central hemodynamics, transport and oxygen consumption in patients who underwent planned surgical interventions in oncologic orthopedics us­ing different regimes of intraoperative fluid supply.

Methods: study included 70 patients aged 18 to 77 years who underwent surgery under combined anesthesia — spinal injection of bupi­vacaine and intravenous propofol-fentanyl anesthesia. Patients of the 1st group (n = 35) were provided with a restrictive mode of intraoperative fluid administration, 2nd (n = 35) — targeted liquid therapy with careful monitoring of cardiac output and tar­get support of the stroke index at a level of more than 35 ml/ m2, mean arterial pressure not less than 90 mm Hg. art. In patients of the 1st group, cardiac preload was often modeled with norepi­nephrine, the 2nd — it was maintained by short-term infusions of a solution of hydroxyethyl starch.

Results: it was established that when the fluid support is limited (group 1), cardiac out­put, vascular tone, and oxygen uptake are significantly reduced. More than 40 % of patients (with 100 % of elderly and senile patients) needed to introduce noradrenaline to stabilize central hemodynamics. Patients of the 2nd group had significantly better cardiac output, vascular tone, oxygen consumption, did not need noradrenaline.

Conclusions: purposeful liquid therapy contributes to the stabilization of central hemodynamics indices, pro­vides better oxygen metabolism, which is especially important for elderly and senile patients in patients who are routinely operated in orthopedic oncology for malignant pathology of lower limb bones under combined anesthesia.

Author Biographies

Kseniia Lyzogub

Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

Sergii Kursov

Kharkiv Medical Academy of Postgraduate Education. Ukraine

Mykola Lyzogub

Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 



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