Prophylaxis of osteoporosis and osteoporotic fractures (a review of literature)

Mykola Korzh, Ninel Dedukh

Abstract


The article analyses scientific data concerning the role of calcium and vitamin D in increasing mineral density of the bone tissue and reducing the risk of fractures. It is shown that high doses of vitamin D and calcium can be recommended to all women both for treatment and reduction of the risk of osteoporotic fractures. The combination of 1,000–1,200 mg of calcium and at least 800 IU of vitamin D a day is considered to be effective. Prospects for studying bone regeneration after an osteoporotic fracture under combined influence of calcium and vitamin D with other antiresorptive drugs are indicated.


Keywords


osteoporosis; fractures; risk factors

References


Дамбахер М. А. Остеопороз и активные метаболиты витамина D: мысли, которые приходят в голову [Текст] / М. А. Дамбахер, Е. Шахт. — М.: S.Y.S. Publishing, 1996. — 140 c.

Значение минеральной плотности и показателей качества костной ткани в обеспечении ее прочности при остеопорозе [Текст] / С. С. Родионова, М. А. Макаров, А. Ф. Колондаев, Н. С. Гаврюшенко // Вестник травматологии и ортопедии. — 2001. — № 2. — С. 76–80.

Насонов Е. Л. Кальций и витамин D: роль в профилактике и лечении остеопороза и других заболеваний человека [Текст] / Е. Л. Насонов // Consilium Medicum. — 1999. — Т. 1, № 5. — С. 212–213.

Abrahamsen B. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe [Text] / B. Abrahamsen // BMJ. — 2010. — №. 340. — P. 54–63.

Adressing the muskolosceletal components of fracture risk with calcium and vitamin D: a rewiev of the evidence [Text] / S. Boonen, H. A. Bichoff-Ferrari, C. Cooper et al. // Calcif. Tissue Int. — 2006. — № 78. — P. 257–270.

Akkus O. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone [Text] / O. Akkus, F. Adar, M.B. Schaffler // Bone. — 2004. — Vol. 34, № 3. — P. 443–453.

Bone density and shape as determinants of bone strength in IGR-1 and/or panidronate-treated ovariectomized rats [Text] / P. Ammann, R. Rizzoli, J.M. Meyer, J.P. Bonjour // Osteoporosis Int. — 1996. — Vol. 6. — P. 219–227.

Ammаnn Р. Эффективность профилактики переломов и качество костной ткани: мечта или реальность? [Text] / P. Ammann // Медикография. — 2004. — Т. 24, № 3. — С. 11–17.

Ascenzi M. G. Structural differences between «dark» and «bright» isolated human osteonic lamellae [Text] / M. G. Ascenzi // J. Struct. Biol. — 2003. — Vol. 141, № 1. — Р. 22–33.

Bell K. L. Super-osteons (remodeling clusters) in the cortex of the femoral shaft: influence of age and gender [Text] / K. L. Bell // Anat. Rec. — 2001. — Vol. 264, № 4. — Р. 378–386.

Boskey A. Bone mineral crystal size [Text] / A. Boskey // Osteoporos Int. — 2003. — Vol. 14, № 5. — Р. 16–21.

Calcium intake and hip fracture risk in men and women: a metaanalysis of prospective cohort studies and randomized controlled trials [Text] / H. A. Bischoff-Ferrari, B. Dawson-Hughes, J. A. Baron et al. // Am. J. Clin. Nutr. — 2007. — № 86. — P. 1780–1790.

Calcium plus vitamin D supplementation and the risk of fractures [Text] / R. D. Jackson, A. Z. LaCroix, M. Gass et al. // N. Engl. J. Med. — 2006. — № 354. — Р. 669–683.

Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and fracture risk: the Decalyos II study [Text] / M. C. Chapuy, R. Pamphile, E. Paris et al. // Osteoporos. — 2002. — № 13. — P. 257–264.

Crofts R. D. Aging changes in osteon mineralization in the human femoral neck [Text] / R. D. Crofts, T. M. Boyce, R. D. Bloebaum // Bone. — 1994. — Vol. 15, № 2. — Р. 147–152.

Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women [Text] / M. C. Chapuy, M. E. Arlot, P. D. Delmas et al. // BMJ. — 1994. — № 308. — P. 1081–1082.

Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials [Text] / H.A. Bischoff-Ferrari, W.C. Willett, J.B. Wong et al. // JAMA. — 2005. — № 293. — Р. 2257–2264.

Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study [Text] / S. Boonen, P. Autier, M. Barette et al. // Osteoporos Int. — 2004. — № 15. — P. 87–94.

Grant A. M. Oral vitamin D3 and calcium for secondary prevention of low trauma fractures in elderly people (Randomized Evaluation of Calcium Or vitamin D, RECORD): a randomized placebo-controlled trial [Text] / A. M. Grant, A. Avenell, M. K. Campbell // Lancet. — 2005. — № 365. — Р. 1621–1628.

Guggenbuhl P. Proportion of patients with ospeoporosis in postmenopausal women performing a bone mineral density diagnosis measurement: The presage study [Text] / P. Guggenbuhl, R. Dufour, S. Liu-Leage // Bone. — 2009. — Vol. 44, № 2. — P. 415.

Hauselmann H. J. A comprehensive review of treatments for postmenopausal osteoporosis [Text] / H. J. Hauselmann, R. Rizzoli // Osteoporos Int. — 2003. — № 14. — P. 2–12.

Hypovitaminosis D myopathy without biochemical signs of os¬teomalacic bone involvement [Text] / H. Glerup, K. Mikkelsen, L. Poulsen, E. Hass et al. // Calcif. Tissue Int. — 2000. — № 66. — Р. 419–424.

In situ detection of 1,25-dihidroxyvitamin D3 receptor in human skeletal muscle tissue [Text] / H. A. Bischoff, M. Borchers, F. Gudat et al. // Histochem J. — 2001. — № 33. — Р. 19–24.

Johnell O. Остеопороз: заболевание, которому все еще уделяется недостаточно внимания [Teкст] / O. Johnell // Медикография. — 2004. — Т. 24, № 3. — С. 1–3.

Kanis J. A. Diagnosis of osteoporosis and assessment of fracture risk [Text] / J. A. Kanis // Lancet. — 2002. — Vol. 359. — P. 1929–1936.

Kiel D. P. Prevention of fractures by hip protectors [Text] / D. P. Kiel // Bone. — 2009. — Vol. 44, № 2. — P. 204.

Low doses of vitamin D with calcium reduce the risk of fractures: patient level analysis of 68500 patients from seven major vitamin D trials in the US and Europe [Text] / B. Abrahamsen, T. Masud, J. A. Robbins et al. // Bone. — 2009. — Vol. 44, № 2. — P. 228.

Massud T. Falls risk assessment and management [Text] / T. Massud // Bone. — 2009. — Vol. 44, № 2. — P. 203.

Melton L. J. I. Biomechanical aspects of fractures. Osteoporosis: etiology, diagnosis and management [Text] / L. J. I. Melton, E. Y. S. Chao, J. Lane. — New York: Raven Press, 1998. — C. 111–113.

Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium [Text] / O. H. Sorensen, B. Lund, B. Saltin et al. // Clin. Sci. — 1979. — № 56. — Р. 157–161.

Nielsen S. P. The fallacy of BMD: a critical review of the diagnostic use of dual X-ray absorptiometry [Text] / S. P. Nielsen // Clin. Rheumatol. — 2000. — Vol. 19, № 3. — Р. 174–183.

Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes [Text] / S. Boonen, P. Haentjens, L. Vandenpunt, D. Vanderschueren // J. Intern. Med. — 2004. — № 255. — Р. 1–12.

Riggs B. L. Overview of osteoporosis [Text] / B. L. Riggs // West. J. Med. — 1991. — № 154. — P. 63–77.

Ross P. D. Risk factors for osteoporotic fracture [Text] / P. D. Ross // Endocrinol. Metab. Clin. North. Am. — 1998. — Vol. 27, № 2. — Р. 289–301.

Rossini M. Post-surgical management of elderly patients with hip fracture [Text] / M. Rossini, P. Olivi, C. Dartizio // Bone. — 2009. — Vol. 44, № 2. — Р. 444.

Ryan D. J. Biomechanical indices of bone turnover in stroke patients are comparable to that of hip fracture patients [Text] / D. J. Ryan, J. G. Browne, M. Healy et al. // Bone. — 2009. — Vol. 44, № 2. — P. 276.

Simpson R. U. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle [Text] / R. U. Simpson, G. A. Thomas, A. J. Arnold // J. Biol. Chem. — 1985. — № 260. — Р. 8882–8891.

The role of calcium and vitamin D in the management of osteoporosis [Text] / R. Rizzoli, S. Boonen, M. L.Brandi et al. // Bone. — 2008. — № 42. — Р. 246–249.

Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis [Text] / B. M. Tang, G. D. Eslick, C. Nowson et al. // Lancet. — 2007. — Vol. 370. — P. 657–656.

Vitamin D deficiency, muscle function, and falls in elderly people [Text] / H. Janssen, M. Samson, H. Verhaar et al. // Am. J. Clin. Nutr. — 2002. — Vol. 75. — P. 611–615.

Vitamin D receptor expression in human muscle tissue decreases with age [Text] / H. A. Bischoff-Ferrari, M. Borchers, F. Gudat et al.// J. Bone Miner. Res. — 2004. — № 19. — Р. 265–269.

Vitamin D3 and calcium to prevent hip fractures in elderly women [Text] / M. C. Chapuy, M. E. Arlot, F. Duboeuf, P. J. Meunier // N. Engl. J. Med. — 1992. — № 327. — Р. 1637–1642.

www.bestmedisrael.com, 2009.




DOI: https://doi.org/10.15674/0030-598720103120-124

Refbacks

  • There are currently no refbacks.


Copyright (c) 2014 Mykola Korzh, Ninel Diedukh

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.