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Experimental study of antiexudative action of «Venogel 911 with horse chestnut»

Andrei Komissarenko, Yulia Avidzba, Valentin Nikolov


Regardless of the degree of injury, it is necessary to use conser­vative methods for the treatment of patients with injuries, in par­ticular medications using local remedies. Among the drugs used to treat chronic venous insufficiency, directly affect the main mechanisms of the pathogenesis of venoactive (phlebi­tropic) agents. They protect the venous wall from the influence of local mediators, oxidants, stabilize the membranes of endo­theliocytes, reduce the permeability of venules and capillaries, increase the tone of the veins and their elasticity, i.e. they have complex endothelioprotective and venoprotective action.

Objective: to investigate the anti-exudative action of «Venogel 911 with horse chestnut» in the experiment.

Methods: a study of the anti-exudative activity of gelabalzam «Venogel 911 with horse chestnut» in comparison with the reference prepa­rations was carried out on the model of thermal inflammation of the mice foot.

Results: the use of drugs resulted in marked suppression of swelling in the foot tissues of animals, which was exposed to a thermal stimulus, as evidenced by a statistically significant decrease in its mass. There were no significant dif­ferences in the anti-exudative activity «Venogel 911 with horse chestnut» in comparison with «Gingoven» and «Dr. Teisse Venen gel».

Conclusions: it has been established that «Venobal gel 911 with horse chestnut» has anti-inflammatory and anti-exudative action and can be used as a means for skin care of the legs, which is prone to manifestations of varicose insufficiency.


anti-exudative action; horse chestnut; «Venogel 911 with horse chestnut»; model of thermal foot inflammation; varicose insufficiency; anti-inflammatory effect


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