Experimental study of antiexudative action of «Venogel 911 with horse chestnut»

Andrei Komissarenko, Yulia Avidzba, Valentin Nikolov

Abstract


Regardless of the degree of injury, it is necessary to use conser­vative methods for the treatment of patients with injuries, in par­ticular medications using local remedies. Among the drugs used to treat chronic venous insufficiency, directly affect the main mechanisms of the pathogenesis of venoactive (phlebi­tropic) agents. They protect the venous wall from the influence of local mediators, oxidants, stabilize the membranes of endo­theliocytes, reduce the permeability of venules and capillaries, increase the tone of the veins and their elasticity, i.e. they have complex endothelioprotective and venoprotective action.

Objective: to investigate the anti-exudative action of «Venogel 911 with horse chestnut» in the experiment.

Methods: a study of the anti-exudative activity of gelabalzam «Venogel 911 with horse chestnut» in comparison with the reference prepa­rations was carried out on the model of thermal inflammation of the mice foot.

Results: the use of drugs resulted in marked suppression of swelling in the foot tissues of animals, which was exposed to a thermal stimulus, as evidenced by a statistically significant decrease in its mass. There were no significant dif­ferences in the anti-exudative activity «Venogel 911 with horse chestnut» in comparison with «Gingoven» and «Dr. Teisse Venen gel».

Conclusions: it has been established that «Venobal gel 911 with horse chestnut» has anti-inflammatory and anti-exudative action and can be used as a means for skin care of the legs, which is prone to manifestations of varicose insufficiency.

Keywords


anti-exudative action; horse chestnut; «Venogel 911 with horse chestnut»; model of thermal foot inflammation; varicose insufficiency; anti-inflammatory effect

References


Levenets VM. Topical issues of sports injuries (Aktualni pytannya sportyvnogo travatyzmu). Sportyvna meditsina. 2004;(1–2):84–90. (in Ukraine)

Levenets VM, Gertsen GI. The use of DMSO in traumatology and orthopedics: A tutorial (Primeneniye DMSO v travmatologii i ortopedii: Uchebnoye posobiye). Moskow: Tsentral'niy institut usovershenstvovaniya vrachey, 1977. 13 p. (in Russian)

Goridova LD. The use of L-lysine ascites in the acute phase of the posttraumatic period after a closed trauma of the musculoskeletal system (Zastosuvannya L-lizinu yestsinatu v gostriy fazi posttravmatichnogo periodu pri zakritiy travmi oporno-rukhovogo aparatu). Vashe zdorov’ya. 2001;(51):4. (in Ukrainian)

Robertson L, Evans C, G Fowkes. Epidemiology of chronic venous disease. Phlebology. 2008;23(3):103–11. doi: 10.1258/phleb.2007.007061.

Sturov N. Chronic venous insufficiency of the lower extremities: epidemiology, pathogenesis, clinic and the principles of therapy (Khronicheskaya venoznaya nedostatochnost' nizhnikh konechnostey: epidemiologiya, patogenez, klinika i printsipy terapii). Vrach. 2008;(4):22–4. (in Russian)

Rational pharmacotherapy of cardiovascular diseases: A guide for practicing doctors (Ratsional'naya farmakoterapiya serdechno-sosudistykh zabolevaniy : Rukovodstvo dlya praktikuyushchikh vrachey).Eds. Chazov EI, Belenkov YuN. Moskow: Littera, 2005. 972 p. (in Russian)

Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2005;111(18):2398–409. doi: 10.1161/01.CIR.0000164199.72440.08.

Pittler МН, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;11:CD003230. doi: 10.1002/14651858.CD003230.pub4.

Rieznikov OG. General ethical principles of animal experiments (Zagal'ni yetichni printsipi yeksperimentiv na tvarinakh). Endokrinologiya. 2003;8(1):142–5. (in Ukrainian)

Gatsura VV. Methods of primary pharmacological research of biologically active substances (Metody pervichnogo farmakologicheskogo issledovaniya biologicheski aktivnykh veshchestv). Moskow: Medicine, 1974. 123 p. (in Russian)

Glantz . S. Medico-biological statistics. Moskow: Practica, 1998. 459 p. (in Russian)

Salimov RM. The main methods of statistical processing of the results of pharmacological experiments/ In: Manual on experimental (preclinical) study of new pharmacological substances. Ed. Khabiev RU. Мoskow: Remedium, 2000. P. 349–54.




DOI: https://doi.org/10.15674/0030-598720172101-104

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Andrei Komissarenko, Yulia Avidzba, Valentin Nikolov

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.