INTERLEUKIN-6 AND ACUTE PHASE PROTEINS AS BIOMARKERS OF SEPTIC OSTEOARTHRITIS

Authors

  • Sadrudin Magomedov SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0003-1958-4037
  • Yuriy Polyachenko SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine
  • Mykola Hrytsai SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0003-1608-7879
  • Iryna Litovka SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0001-9163-3572
  • Vasyl Sabodash SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0002-3214-3298
  • Natali Dekhterenko SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine
  • Taisiia Kuzub SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.15674/0030-59872025266-70

Keywords:

Interleukin-6, acute phase proteins, septic osteoarthritis

Abstract

Septic arthritis (SA) is a severe and rapidly progressive joint infection and a potentially life-threatening condition that can affect all age groups. Due to the lack of effective methods for early detection and assessment of treatment outcomes, measurement f biochemical markers (biomarkers) is a promising method for monitoring the disease. The aim of the study was to determine the diagnostic significance of inflammatory biomarkers (IL-6, CRP, haptoglobin, ceruloplasmin) in patients with septic joint inflammation of various localizations. Methods. The study analyzed blood serum from 54 male and female subjects. Of these, 18 were conditionally healthy and entered group I (control), and 36 patients were diagnosed with septic osteoarthritis of joints of various localization in the skeleton. Of these, 18 had SA of the knee joint; 13 patients had SA of the hip joint and 5 had SA of the ankle joint. Results. Patients with septic arthritis of the knee and hip joints had significantly increased levels of IL-6 and acute phase proteins in the blood serum. We believe that it is the enhanced synthesis of the pro-inflammatory cytokine IL-6 and acute phase proteins that plays a significant role in the pathophysiology of the inflammatory response, which initiates a chain of reactions that lead to cartilage degradation and further complication of inflammatory processes in the joint. Therefore, these biomarkers can be tools for diagnosing the progression of this disease in both preclinical and clinical studies. The results obtained emphasize the importance of identifying inflammatory biomarkers for diagnosing the progression of septic arthritis in both preclinical and clinical studies to establish the stage of the disease and predict clinical outcome.

Author Biographies

Sadrudin Magomedov, SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv

MD, Prof.

Yuriy Polyachenko, SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv

MD, Prof.

Mykola Hrytsai, SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv

MD, Prof.

Iryna Litovka, SI «National Institute of Traumatology and Orthopedics of the NAMS of Ukraine», Kyiv

MD, Prof.

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How to Cite

Magomedov, S., Polyachenko, Y., Hrytsai, M., Litovka, I., Sabodash, V., Dekhterenko, N., & Kuzub, T. (2025). INTERLEUKIN-6 AND ACUTE PHASE PROTEINS AS BIOMARKERS OF SEPTIC OSTEOARTHRITIS. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 66–70. https://doi.org/10.15674/0030-59872025266-70

Issue

No. 2 (2025)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2025 Sadrudin Magomedov, Yuriy Polyachenko, Mykola Hrytsai, Iryna Litovka, Vasyl Sabodash, Natali Dekhterenko, Taisiia Kuzub

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