Correction of the structural-functional state of the osseous and cartilaginous tissues in experimental conditions of alimentary hypovitaminosis D and hypervitaminosis

Authors

  • Georgy Gaiko
  • Olexiy Kalashnikov
  • Larisa Apuhovskaya
  • Andrey Kalashnikov
  • Anton Brusko
  • Valentyna Wasilewska
  • Antonina Bezusyak
  • Olena Lototska

DOI:

https://doi.org/10.15674/0030-59872011388-94

Keywords:

osteoporosis, vitamin D3, hypervitaminosis D, hypovitaminosis D

Abstract

Therapeutic efficacy of different doses of vitamin E in combination with vitamin D3 in conditions of hypovitaminosis D and hypervitaminosis was experimentally studied in 105 Wistar rats. It as proved that a dose of 6 mg of vitamin E was universal, safe and most effectively facilitated restoration of mineral metabolism, structure and functions of the epiphyseal cartilage and compact osseous tissue in conditions of alimentary hypovitaminosis D and hypervitaminosis. The conducted study makes it possible to recommend inclusion of drugs, which contain vitamins E and D3, into multimodality therapy for orthopaedic patients.

References

  1. Бочков Н.П. Клиническая генетика / Н.П. Бочков. — М.: Медицина, РЭОТАР-МЕД, 2001. — 448 с.
  2. Вагнер В.К. Методы и результаты изучения изоферментов (кишечной и печеночной фракций) сывороточной щелочной фосфатазы при острых хирургических заболеваниях органов брюшной полости / В.К. Вагнер, В.М. Путилин, Г.Г. Харабурга // Вопр. мед. химии. — 1981. — № 6. —С. 752−754.
  3. Витамин D и костная система / Г.В. Гайко, А.Т. Бруско, А.В. Калашников и др. — К.: OОО «Книга-Плюс», 2008. — 147 с.
  4. Земцовский Э.В. Соединительнотканная дисплазия сердца / Э.В. Земцовский. — СПб: ТОО «Политекс-Норд-Вест», 2000. — 155 с.
  5. Науково-практичні рекомендації з утримання лабораторних тварин та робота з ними / Ю.М. Кожем’якін, О.С. Хромов, М.А. Філоненко та ін. — К.: Авіцена, 2002. — 156 с.
  6. Насонов ЕЛ. Проблема остеопороза в ревматологии / Е.Л. Насонов, И.А. Скрипникова, В.А. Насонова. — М: СТИН, 1997. — 429 с.
  7. Сергеев И.Н. Роль витамина Е в обмене и рецепции витамина Д / И.Н. Сергеев, Ю.П. Ахрапчев, В.Б. Спиричев // Биохимия. — 1990. — Вып. 11, № 55. — С. 1989−1994.
  8. Сіменач Б.І. Синдром артрозуючої деформації, зумовлений спадковою схильністю. Клінічні особливості / Б.І. Сіменач, П.І. Снісаренко, О.П. Бабуркіна // Ортопед. травматол. — 2004. — № 3. — С. 95−100.
  9. Терминология, определенная с позиции клиники, классификация врожденной дисплазии соединительной ткани / В.М. Яковлев, Е.И. Нечаева, И.А. Викторова и др. // Тез. симпозиума: Врожденные дисплазии соединительной ткани. — Омск, 1990. — С. 3−5.
  10. Dyce В. A rapid non enzimatic assay for 2,3-diphosphoglicerate. Multiple speciman of blood / В. Dyce, S. Bessan // Enviromental Health. — 1973. — Vol. 27, № 2. — P. 205−207.
  11. Reriew of the concept of D «Sufficiency and insufficiency» / A.C. Gomez, D.H. Nares, G.H. Rodriguez et al. // Nefrologia. — 2003. — № 2. — P. 73−77.
  12. Jain Sushil R. Relationship between elevated lipid peroxides, vitamin E deficiency and hypertension in preedampsia / R. Jain Sushil, Rodney Wise // Моl. Cell Biochem. — 1995. — Vol. 151, № 1. — P. 33−38.
  13. Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different? / Т. MacAlinden, Y. Zhang, M.T. Hannan et al. // J. Rheumatol. — 1997. — № 23. — P. 332−337.
  14. Schilt M. Optimal age for hip sonography screenining / M. Schilt // Ultrashall med. — 2001. — Bd. 22, № l. — Р. 39−47.
  15. Effect of antioxidants of knee cartilage and bone in healthy, middle- aged subjects/ Y. Wang A.M. Hodge, A.E. Wluka et al. // Arthritis Res. Ther. — 2007. — № 9. — Р. 66–71.

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How to Cite

Gaiko, G., Kalashnikov, O., Apuhovskaya, L., Kalashnikov, A., Brusko, A., Wasilewska, V., Bezusyak, A., & Lototska, O. (2011). Correction of the structural-functional state of the osseous and cartilaginous tissues in experimental conditions of alimentary hypovitaminosis D and hypervitaminosis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 88–94. https://doi.org/10.15674/0030-59872011388-94

Issue

No. 3 (2011)

Section

ORIGINAL ARTICLES

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Copyright (c) 2014 Georgy Gaiko, Olexiy Kalashnikov, Larisa Apuhovskaya, Andrey Kalashnikov, Oleksandr Brusko, Valentyna Wasilewska, Antonina Bezusyak, Olena Lototska

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