Еffect of radial extracorporeal shock wave therapy on the healing of experimental bone defect

Authors

  • Genry Hertsen
  • Se Fei
  • Roman Ostapchuk
  • Sergey Malokhat’ko
  • Anatoliy Kostenko
  • Victor Zherebchuk

DOI:

https://doi.org/10.15674/0030-59872016411-16

Keywords:

reparative osteo¬genesis, radial extracorporeal shock wave therapy

Abstract

The favorable effect of low energy extracorporeal shock wave therapy (ECSHVT) on reparative osteogenesis has repeatedly discussed in the scientific literature. However, the mechanisms of influence of this factor on bone are not investigated.

Objec­tive:to explore the mechanism of action of low energy ECSHVT for reparative regeneration of bone tissue. Methods: the study performed in 85 adult rabbits, male (weight from 2.9 to 3.4 kg), which were divided into three groups: intact (5 animals), control (40) and research (40). Research group rabbits in the area of trauma (penetrating perforated rum defect diameter 2.5 mm proximal tibial metaphysis) received 4 sessions of ECSHVT intervals of 4 days with a frequency of 1–4 Hz strokes, work­ing pressure 1–5⋅105 5 Pa 2 thousand. Strikes for the procedure with a maximum energy of 0.48 mJ. After 2, 15, 30 and 45 days after injury made X-morphological and biochemical (collagen, glycosaminoglycans — GAG) study of bone regenerate.

Re­sults: on the background of posttraumatic catabolic phase pe­riod (day 2) in control and experimental animal groups found reduction of collagen and GAG 29.1 and 32.6 % respectively, p < 0.001. Against the background of the anabolic phase of post­traumatic period (15, 30 and 45th days) stated increase col­lagen and GAG content in both groups of animals in research and figure was higher by 6,8–12,7 % and 11,2–15% respectively (p < 0.05). As a result radiomorphological studies revealed that ECSHVT influence on reparative osteogenesis occurs due to mi­crocirculation disorders of bone — vasodilation, increased per­meability of the vessel walls, blood cells out of the capillaries.

Conclusion: activation of the biosynthesis of collagen and GAG dentified under the influence of ECSHVT and changes in blood circulation accompanied by strengthening bone, forming mas­sive areas of endosteal regenerate bone that provided fusion of metaphysial defect of the tibia.

References

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How to Cite

Hertsen, G., Fei, S., Ostapchuk, R., Malokhat’ko, S., Kostenko, A., & Zherebchuk, V. (2017). Еffect of radial extracorporeal shock wave therapy on the healing of experimental bone defect. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 11–16. https://doi.org/10.15674/0030-59872016411-16

Issue

No. 4 (2016)

Section

ORIGINAL ARTICLES

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Copyright (c) 2017 Genry Hertsen, Se Fei, Roman Ostapchuk, Sergey Malokhat’ko, Anatoliy Kostenko, Victor Zherebchuk

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