Effect of Aclasta drug on the structural-functional state of the bone tissue and reparative regeneration processes in conditions of postmenopausal osteoporosis

Vladyslav Povorozniuk, Volodymyr Vayda, Ninel Dedukh, Natalya Grigoryeva

Abstract


As a result of their experimental study on 32 white young female rats (the animals’ age by the moment of entering the research was 5 months, the body weight was 181 ± 5 g) with use of methods of dental densitometry and histological investigation, the authors demonstrated that administration of Aclasta drug to female rats after ovariectomy and with well-developed osteoporosis during reproduction of a perforating defect caused a reliable rise in indices of mineral density and saturation of the osseous tissue, did not affect the process of reparative regeneration and facilitated formation of an adequate bone regenerate in areas of compact and spongy bones.

Keywords


postmenopausal osteoporosis; repair regeneration; antiresorptive pharmacokinetics

References


Автандилов Г.Г. Медицинская морфометрия / Г.Г. Автандилов. — М.: Медицина, 1990. — 381 с.

Лабораторные животные. Разведение, содержание, использование в эксперименте / И.П. Западнюк, В.И. Западнюк, Е.А. Захария, Б.В. Западнюк. — К.: Вища школа, 1983. — 383 с.

Остеопороз: эпидемиология, клиника, диагностика, профилактика и лечение; под ред. Н.А. Коржа, В.В. Поворознюка, Н.В. Дедух, И.А. Зупанца. — Х.: Золотые страницы, 2002. — 648 с.

Поворознюк В.В. Захворювання кістково-м’язової системи в людей різного віку (вибрані лекції, огляди, статті): у 3 т. / В.В. Поворознюк. — Т. 2. — К., Експрес. — 2009. — 482 с.

Фролькис В.В. Экспериментальный остеопороз (модели, механизмы развития возрастного остеопороза) / В.В. Фролькис, В.В. Поворознюк, О.А. Евтушенко // Пробл. остеологии. — 1999. — Т. 2, № 3. — C. 4–22.

Effect of zoledronic acid in an L6–L7 rabbit spine fusion model / R. Bransford, E. Goergens, J. Briody et al. // Eur. Spine J. — 2007. — Vol. 16. — P. 557–562.

Matos M.A. The effect of zolondronate on bone remodeling during the healing process / M.A. Matos, F.P. Araujo, F.B. Paixao // Acta Cirurg. Bras. — 2007. — Vol. 22, № 2. — P. 115–119.

Systemic zoledronate treatment both prevents resorption of allograft bone and increases the retention of new formed bone during revascularization and remodelling. A bone chamber study in rats / J. Åstrand, A.K. Harding, P. Aspenberg, M. Tägil // BMC Musculoskeletal Disorders. — 2006. — Vol. 7, № 63. — Р. 1471–2474.




DOI: https://doi.org/10.15674/0030-59872011226-32

Refbacks

  • There are currently no refbacks.


Copyright (c) 2014 Vladyslav Povorozniuk, Volodymyr Vayda, Ninel Diedukh, Natalya Grigoryeva

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.