The efficacy of structure-modified drugs in the treatment of patient with osteoarthritis and hyperuricemia
Keywords:osteoarthritis, hyperuricemia, structure modifying agents, chondroitin sulfate, citrate complex
AbstractThe goal: to investigate the efficacy of chondroitin-4,6-sulfate (as a monotherapy and combined with potassium-sodium-hydrocitrate complex) in the patients with osteoarthritis (OA) and concomitant hyperuricemia and its influence on the dynamics of indices of inflammation process, purine, carbohydrates, lipidic metabolism. Methods: 78 patients with OA (62 females, 16 males) at the age from 35 to 75 years were included in the investigation. All patients were divided on 3 groups. The patients of I group (30 patients with OA but without concomitant hyperuricemia) and II group (32 patients with OA and concomitant hyperuricemia) took chondroitin-4,6-sulfate; III group (16 patients with OA and concomitant hyperuricemia) took chondroitin-4,6-sulfate and potassium-sodium-hydrocitrate complex. The dynamics of different indices (VAS, WOMAC, Lequesne, uric acid, IL-1β, IGF-1, NO, CRP, general clinical) on the background of therapy were assessed. Statistical analysis was performed wsing SPSS Statistics. Results: significant pain relief according to VAS, decrease of indices WOMAC and Lequesne after 6 months of therapy were revealed in all groups. However, more significant (0,05) decrease of VAS score while walking and WOMAC index were observed in III patient group comparing with
I and II groups. After 6 moths of treatment the statistically significant decrease of IL-1, NO, and statistically significant increase of IGF-1 were observed. Patients of III groups had decrease of IL-1 (p < 0.05) more substantial than patients of I and II groups. The tendency towards increase of uricemia in I group, its statistically significant increase in II group and decrease in III group were revealed. Conclusion: the usage of medication with chondroitin-4,6-sulfate to treat the patients with OA and concomitant hyperuricemia is pathogeneticaly grounded and clinically promising, however, its influence on the uricemia level should be taken into consideration and differential approach to the treatment of patients with OA and concomitant hyperuricemia should be planned prescribing structure modifying agents combined with medication lowering hyperuricemia.
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