Experimental substantiation of combined fixation of tumor endoprothesis for the replacement of diaphyseal defects of rat long bones


  • Oleg Vyrva
  • Dmytro Mikhanovsky
  • Yanina Golovina
  • Olga Nikolchenko
  • Mykhaylo Karpinsky




bone resection, modular tumor endoprothesis, femur, biomechanics, radiography, rats


Goal: to compare the durability of fixation of endoprothesis for replacement of postresection femur defects in experimental animals under bending and strain loading. Methods: investigation was performed on 20 non-linear white rats at the age of 6 months. Partial resection of femur middle 1/3 and defect replacement with modular endoprothesis was performed. Average diameter and lenght of intramedullary canal of rat femur were defined using radiographic and osteometrtic investigation of the rats of analogous age, gender and body-weight. The sizes of intramedullary stems for fixation of endoprothesis in bone canals were claculated using obtained data. Plate was fixed with screws to the body of endoprothesis and after implantation it adjoined tightly to distal femur fragment. Intramedullary stems and plate were covered with a layer of corundum ceramics. The animals were devided on 2 groups: experimental group — using of modular endoprtohesis with plate; control group — using of modular endoprtohesis without plate. 3 months after operation the durability of endoprothesis fixation to bone diaphysis were studied under bending and strain loading. Results: control group — just in 3 rats of 10 the stable fixation of endoprothesis was observed. According to index of bending moment the best results were revealed for intact femurs — (1,89 ± 0,81) N•m. Conclusion: use of endoprothesis with additional plate fixation allowed to obtain more durable fixation «implant-bone» and significantly decreased the quantity of postoperative complictions.


Vyrva O. E. Evaluation of functional results after treatment of a modular tumor endoprosthesis / O. E. Vyrva, I. V. Shevchenko, R. V. Malyk, Ya. A. Golovina // Proceedings of XV Congress of orthopedic trauma Ukraine. — Kharkiv, 2013. — P. 297.

Vyrva O. E. Modern approach to treatment of malignant bone tumors (literature review) (P.1) / O. E. Vyrva // Orthopedics, Traumatology and Prosthetics. — 2013. — № 4. — P. 116–121.

Hrabovoy А. F. Endoprosthesis of shoulder joint / А. F. Hrabovoy, V. А. Rodichkin // Orthopedics, Traumatology and Prosthetics. — 1983. — № 1. — P. 50–51.

Dubnov P. U. Statistical information processing using SPSS / P. U. Dubnov. — М.: AST, 2005. — 140 p.

Kots R. Modern methods of treatment of malignant tumors: Lecture / R. Kotz // N. N. Priorov Herald of Orthopedics and Traumatology. — 1994. — № 4. — P. 62–68.

Makhson A.N. On the concept of adequate surgery in relation to patients with tumors of the shoulder and pelvic girdle limbs / A. N. Makhson: abstract book The first international symposium plastic and reconstructive surgery in oncology. — Moscow, 1997. — P. 3–4.

Nasledov А. D. SPSS: Computer analysis of data in psychology and social sciences / A. D. Nasledov. — SPb: Piter, 2005. — 416 p.

Orlov A. I. Applied statistics / A. I. Orlov. — М.: Exam, 2004. — 98 p.

The role of intact operations in the treatment of patients with tumors of the bone of the shoulder girdle / А. А. Amiraslanov, V. А. Sokolovskiy, V. D. Aliyev [et al.]: thes. rep. II Congress of Oncologists of CIS // Oncology. — 2000. — С. 781.

Functional and oncological outcomes after limb-salvage sur¬gery for primary sarcomas of the upper limb / E. H. Wright, S. Gwilym, C. L. Gibbons [et al.] // J. Plast. Reconstr. Aesthet. Surg. — 2008. — Vol. 61. — P. 382–387, doi: http://dx.doi.org/10.1016/j.bjps.2007.01.080.

Getty P. J. Complications and functional outcomes of recon¬struction with an osteoarticular allograft after intra-articular resection of the proximal aspect of the humerus / P. J. Getty, T. D. Peabody // J. Bone Joint Surg. Am. — 1999. — Vol. 81-А, № 8. — P. 1138–1146.

Segmental limb reconstruction after tumor resection / H. T. Temple, T. R. Kuklo, R. A. Lehman [et al.] / Am. J. Orthop. — 2000. — Vol. 29. — P. 524–529.

How to Cite

Vyrva, O., Mikhanovsky, D., Golovina, Y., Nikolchenko, O., & Karpinsky, M. (2015). Experimental substantiation of combined fixation of tumor endoprothesis for the replacement of diaphyseal defects of rat long bones. ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, (4), 49–54. https://doi.org/10.15674/0030-59872015449-54




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