Bone mineral density and fracture risk in patients with type ii diabetes mellitus (review)

Authors

  • Alexandr Sykal

DOI:

https://doi.org/10.15674/0030-598720153126-132

Keywords:

bone mineral density, diabetes mellitus type II, risk of fractures

Abstract

The purpose of a literature review was to analyze the peculiarities of bone tissue organization in patients with diabetes mellitus (DM) II type by evaluating bone mineral density (BMD) and fracture risk. Review consists of three sections, which are the results of studies BMD and fracture risk in patients with type II diabetes, as well as pathogenesis of disorders in bone tissue in case of the said disease. During study of men and women with DM type II we revealed differences in BMD parameters in different segments of the skeleton. Most researchers have concluded that for DM type II BMD increased in the axial skeleton. There were positive correlation between body mass index and femoral neck BMD in women with DM type II. Potential factors affecting an increasing BMD in cases of DM type II include obesity, hyperinsulinemia, increased levels of androgens associated with obesity in women. However there are some works in which there were revealed no changes in BMD compared to healthy individuals or proven reducing of this parameter. On the one hand, the discrepancy of the indeces can be explained by population characteristics, on the other hand - the study was conducted in patients of different age and disease duration, and on different bone densitometers. Not in all cases they took into account comorbidities and features of the metabolic background of the organism. It was determined that gender features also appear on the BMD index. Either in the population or in patients with DM type II it was fixed lower skeletal mineralization in women comparing to men which one may explain by the increased risk of fracture in women. However despite on the high rates of BMD fracture risk in patients with DM type II is increased compared to healthy people indicating the need to consider other factors, for instance: risk of falls, mi­croarchitecture and features of bone remodeling, etc.

References

  1. Kurra S. Diabetes and bone health: the relationship between diabetes and osteoporosis-associated fractures / S. Kurra, E. Siris // Diabetes Metab. Res. Rev. — 2011. — Vol. 27, № 5. — P. 430–435, doi: 10.1002/dmrr.1197.
  2. Schwartz A. V. Diabetes, fracture, and bone fragility / A. V. Schwartz, D. E. Sellmeyer // Curr. Osteoporosis Rep. — 2007. — Vol. 5, № 3. — P. 105–111.
  3. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture / M. Janghorbani, R. M. van Dam, W. C. Willett, F. B. Hu // Am. J. Epidemiol. — 2007. — Vol. 166. — P. 495–505.
  4. Jackuliak P. Osteoporosis, fractures, and diabetes [web source] / P. Jackuliak, J. Payer // International Journal of Endocrinology. — 2014. — Vol. 2014. — Access mode: http://dx.doi.org/10.1155/2014/820615.
  5. Dedov I. Algorithms specialized medical care to patients with diabetes mellitus / ed. I. Dedov, MV Shestakova. - 5th ed. - M., 2011. - 115 p.
  6. Zimmet P. Z. The growing pandemic of type 2 diabetes a crucial need for preventation and improved detection / P. Z. Zimmet // Medicografia. — 2011. — Vol. 33, № 106. — P. 15–21.
  7. International Diabetes Federation, IDF Diabetes Atlas. — 6th ed. — Brussels: International Diabetes Federation, 2013.
  8. Biryukova E.V. Osteoporosis: view endocrinologist / E.V. Biryukova // Farmateka. - 2012. - № 112. - S. 32-39.9.
  9. Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study / V. Rakic, W. A. Davis , S. A. Chubb [et al.] // Diabetologia. — 2006. — Vol. 49, № 5. — Р. 863–871.
  10. Osteoporosis in the practice of physician-internist / [V. B. Povoroznyuk, NV Grigorieva, Orlik T. et al.]. - K .: Ekspres, 2014. - 198 p.
  11. Brandi M.L. Healthy bones and diabetes / M.L. Brandi // Osteoporosis and osteopathy. - 2011. - № 2. - S. 23-26.12.
  13. Pan H. Association between bone mineral density and type 1 diabetes mellitus: a meta-analysis of cross-sectional studies / H. Pan, N. Wu, W. Hei // Diabetes metabolism. — 2014. — Vol. 30 (7). — P. 531–542, doi: 10.1002/dmrr.2508.
  15. Schwartz A. V. Diabetes mellitus: does it affect bone / A. V. Schwartz // Calcif. Tissue Int. — 2003. — Vol. 73. — P. 515–519.
  16. Type 2 diabetes is associated with increased bone mineral den¬sity in Mexican-American women / W. H. L. Kao, C. M. Kam¬merer, J. L. Schneider [et al.] // Arch. Med. Res. — 2003. — Vol. 34. — P. 399–406.
  17. Leidig-Bruckner G. Diabetes mellitus a risk for osteoporosis? / G. Leidig-Bruckner, R. Ziegler // Exp. Clin. Endocrinol. Diabetes. — 2001. — Vol. 109, Suppl 2. — P. S493–S514.
  18. Evaluation of bone turnover in postmenopausal patients with type 2 diabetes mellitus using biochemical markers and bone mineral density measurements / O. Akin, K. Gol, M. Akturk, S. Erkaya // Gynecol. Endocrinol. — 2003. — Vol. 17. — P. 19–29.
  19. Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group / D. C. Bauer, W. S. Browner, J. A. Cauley [et al.] //Ann. Intern. Med. — 1993. — Vol. 118. — P. 657–665.
  20. Bone mineral density in women with type II diabetes mellitus / R. S. Weinstock, R. S. Goland, E. Shane [et al.] // J. Bone Miner. Res. — 1989. — Vol. 4. — P. 97–101.
  21. Bone density in non-insulin dependent diabetes mellitus. The Rotterdam Study / P. L. Van Daele, R. P. Stolk, H. Burger [et al.] // Ann. Intern. Med. — 1995. — Vol. 122. — P. 409–414.
  22. The effects of lifestyle, dietary dairy intake and diabetes on bone density and vertebral deformity prevalence: the EVOS study / M. Lunt, P. Masaryk, C. Scheidt-Nave [et al.] // Osteoporos Int. — 2001. — Vol. 12. — P. 688–698.
  23. Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance? / E. M. Dennison, H. E. Syddall, A. Aihie Sayer [et al.] // Diabetology. — 2004. — Vol. 47, № 11. — P. 1963–1968.
  24. Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: cross-sectional results from the Canadian Multicentre Osteoporosis Study / D. A. Hanley, J. P. Brown, A. Tenenhouse [et al.] // J. Bone Miner. Res. — 2003. — Vol. 18 (4). — P. 784–790.
  25. Ruyatkina LA bone health in women c sa-type 2 diabetes, depending on the functional state of the ovaries [electronic resource] / LA Ruyatkina, Lomov AV // Health and Education in Siberia. — 2012. — № 1. — Access mode: http://ngmu.ru/cozo/mos/article/text_full.php?id=627.
  26. Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus / P. Gerdhem, A. Isaksson, K. Akesson, K. J. Obrant // Osteoporos. Int. — 2005. — Vol. 16 (12). — P. 1506–1512.
  27. Association between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes / T. Yamaguchi, I. Kanazawa, M. Yamamoto [et al.] // Bone. — 2009. — Vol. 45. — P. 174–179, doi: 10.1016/j.bone.2009.05.003.
  28. Association between bone mineral density and type 2 diabetes mellitus / S. Raj, S. J. Baiju, R. Vijayan, G. Rajan // British Journal of Research. — 2014. — № 1–2. — P. 63–67.
  29. Bone mass density in diabetic women: is there a detrimental effect? / K. Al-Zaabi, H. E. Badr, S. Mahussain [et al.] // Middle East J. Age Aging. — 2008. — Vol. 5. — P. 12–17.
  30. Bone mineral density in diabetes mellitus / A. Giacca, A. Fassina, F. Caviezel [et al.] // Bone. — 1988. — Vol. 9, № 1. — P. 29–36.
  31. Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus / G. Hampson, C. Evans, R. J. Petitt [et al.] // Diabetologia. — 1998. — Vol. 41, № 11. — P. 1314–1320.
  32. Bone mineral density measured by dual energy X-ray absorptiometry in patients with non-insulin-dependent diabetes mellitus / M. Wakasugi, R. Wakao, M. Tawata [et al.] // Bone. — 1993. — Vol. 14, № 1. — P. 29–33.
  33. Osteopenia associated with non-insulin-dependent diabetes mellitus: what are the causes? / F. Gregorio, S. Cristallini, F. Santeusanio [et al.] // Diabetes Res. Clin. Pract. — 1994. — Vol. 23, № 1. — P. 43–54.
  34. Increased bone mineral density in postmenopausal women with type 2 diabetes mellitus / I. Hadzibegovic, B. Miskic, V. Cosic [et al.] // Ann. Saudi. Med. — 2008. — Vol. 28. — P. 102–104.
  35. Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients / T. Majima, Y. Komatsu, T. Yamada [et al.] // Osteoporos. Int. — 2005. — Vol. 16 (8). — P. 907–913.
  36. Prevalence and predictors of osteopenia and osteoporosis in postmenopausal Chinese women with type 2 diabetes / Y. Zhou, D. Zhang, J. Wang [et al.] // Diabetes Res. Clin. Pract. — 2010. — Vol. 90 (3). — P. 261–269, doi: 10.1016/j.diabres.2010.09.013.
  37. Dutta M. K. Evaluation of bone mineral density in type 2 diabetes mellitus patients before and after treatment / M. K. Dutta, R. Pakhetra, M. K. Garg // Med. J. Armed. Forces India. — 2012. — Vol. 68 (1). — P. 48–52, doi: 10.1016/S0377-1237(11)60120-2.
  38. Decreased bone mineral density in men with metabolic syndrome alone and with type 2 diabetes / S. Yaturu, S. Humpherey, C. Landry, S. K. Jain // Med. Sci. Monit. — 2009. — Vol. 15. — P. 5–9.
  39. Bone health and type 2 diabetes mellitus: systematic rewiev / E. Gorman, A.M. Chudyk, K.M. Madden, M.C. Ashe // Physiother Can. — 2011. — Vol. 63 (1). — P. 8–20, doi: 10.3138/ptc.2010-23bh.
  40. Sykal A. Bone mineral density in women with type 2 diabetes / A.A. Sykal: Abstracts of scientific and practice conf. "Current research fields: from theory to practice." - Cheboksary, 2015. - P. 60-63.
  41. Bone structure and turnover in type 2 diabetes mellitus / A. Shu, M. T. Yin, E. Stein [et al.] // Osteoporos Int. — 2012. — Vol. 23, № 2. — P. 635–641, doi: 10.1007/s00198-011-1595-0.
  42. Association between bone mineral density and type 2 diabetes mellitus:a meta-analysis of observational studies / L. Ma, L. Oei, L. Jiang [et al.] // Eur J. Epidemiol. — 2012. — Vol. 27, № 5. — P. 319–332, doi: 10.1007/s10654-012-9674-x.
  43. Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications / M. Yamamoto, T. Yamaguchi, M. Yamauchi [et al.] // J. Bone Miner. Res. — 2009. — Vol. 24, № 4. — P. 702–709, doi: 10.1359/jbmr.081207.
  44. Risk of fractures and bone abnormalities in postmenopausal women with type 2 diabetes mellitus // M. G. Filippela, A. Faggiano, A. Falchetti [et al.] // Clin. Cases Miner. Bone Metab. — 2010. — Vol. 7, № 2. — P. 126–129.
  45. Bone mass and strength in older men with type 2 diabetes: the osteoporotic fractures in men study / M. A. Petit, M. L. Paudel, B. C. Taylor [et al.] // J. Bone Miner. Res. — 2010. — Vol. 25, № 2. — P. 285–291, doi: 10.1359/jbmr.090725.
  46. Distal radius fractures in older women: a 10 year follow-up study of descriptive characteristics and risk factors. The study of osteoporotic fractures / M. T. Vogt, J. A. Cauley, M. M. Tomaino [et al.] // J. Am. Geriatr. Soc. — 2002. — Vol. 50. — P. 97–103.
  47. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes — a meta-analysis / Р. Vestergaard // Osteoporosis Int. — 2007. — Vol. 18, № 4. — P. 427–444.
  48. Shear strength behavior of human trabecular bone / A. Sanyal, A. Gupta, H. H. Bayraktar [et al.] // J. Biomech. — 2012. — Vol. 45, № 15. — P. 2513–2519, doi: 10.1016/J. Biomech.2012.07.023.
  49. Hvisyuk AN Assessment of fracture risk in patients with diabetes mellitus type II / AN Hvisyuk AA Sykal, VA Babaljan AV Kalchenko // Orthopedics, Traumatology and Prosthetics. — 2015. — № 2. — С. 35–41, doi: http://dx.doi.org/10.15674/0030-59872015235-41.
  50. Jackuliak P. Bone quality in diabetes mellitus type 2 Bone
  51. Abstracts PP215 (2014) 3 / P. Jackuliak, Z. Killinger, J. J. Payer: abstracts of European Calcified Tissue Society Congress (Czech Republic, Prague 17–20 May 2014). — Prague, 2014. — P. 215.
  52. Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do? / S. A. Abdulameer, S. A. Sulaiman, M. A. Hassali [et al.] // Patient Prefer Adherence. — 2012. — Vol. 6. — P. 435–448.
  53. Yamaguchi T. Bone fragility in type 2 diabetes mellitus / T. Yamaguchi // World J. Orthop. — 2010. — Vol. 1, № 1. — P. 3–9, doi: 10.5312/wjo.v1.i1.3.
  54. Yamaguchi T. Bone metabolism and fracture risk in type 2 diabetes mellitus / T. Yamaguchi, T. Sugimoto // Bonekey Rep. — 2012. — Vol. 1. — Article 36, doi: 10.1038/bonekey.2012.27.
  55. LRP6 mutation in a family with early coronary disease and metabolic risk factors / A. Mani, J. Radhakrishnan, H. Wang [et al]. // Science. — 2007. — Vol. 315. — P. 1278–1282.
  56. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes / S. F. Grant, G. Thorleifsson, I. Reynis¬dottir [et al.] // Nat. Genet. — 2006. — Vol. 38. — P. 320–323.
  57. Smith U. TCF7L2 and type 2 diabetes — we WNT to know / U. Smith // Diabetologia. — 2007. — Vol. 50. — P. 5–7.
  58. Owen K. R. Genetics of type 2 diabetes / K. R. Owen, M. I. Mc Carthy // Curr. Opin. Genet. Dev. — 2007. — Vol. 17. — P. 239–244.
  59. Serum undercarboxylated osteocalcin was inversely associ¬ated with plasma glucose leveland fat mass in type 2 diabetes mellitus / I. Kanazawa, T. Yamaguchi, M. Yamauchi [et al.] // Osteoporos Int. — 2011. — Vol. 22 (1). — P. 187–194, doi: 10.1007/s00198-010-1184-7.
  60. Maor G. The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor / G. Maor, E. Karnieli // Endocrinology. — 1999. — Vol. 140 (4). — P. 1841–1851.
  61. The association between insulin levels and cortical bone: find¬ings from a cross-sectional analysis of pQCT parameters in adolescents / A. Sayers, D. A. Lawlor, N. Sattar, J. H. Tobias // J. Bone Miner. Res. — 2012. — Vol. 27, № 3. — P. 610–618, doi: 10.1002/jbmr.1467.
  62. Povoroznyuk V.V. Deficiency and insufficiency of vitamin D: epidemiology, diagnosis and treatment / V.V. Povoroznyuk, P. Pludovski. - Donetsk: O. Zaslavsky, 2014. — 262 с.
  63. Fukazawa M. Role of oxidative stress in diabetic bone disorder / M. Fukazawa // Bone. — 2009. — Vol. 45, Suppl. 1. — P. S35–S38.
  64. Hamada Y. Role of oxidation stress in diabetic bone disorder / Y. Hamada, H. A. Fuji, M. Fukugawa // Bone. — 2009. — Vol. 45, Suppl. 1. — P. S535–S538.
  65. Williams J. P. Regulation of osteoclstic bone resorption by glucose / J. P. Williams, H. C. Blair, J. M. Mc Donald // Biochem. Biophys. Res. Commun. — 1997. — Vol. 235. — P. 646–651.
  67. Influence of nonenzymatic glycation on biomechanical properties of cortical bone / D. Vashishth, G. J. Gibson, L. Khoury [et al.] // Bone. — 2001. — Vol. 28. — P. 195–201.

Downloads

How to Cite

Sykal, A. (2015). Bone mineral density and fracture risk in patients with type ii diabetes mellitus (review). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 126–132. https://doi.org/10.15674/0030-598720153126-132

Issue

No. 3 (2015)

Section

DIGESTS AND REVIEWS

License

Copyright (c) 2015 Alexandr Sykal

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).