Trabecular bone score in clinical practice (review)

Authors

  • Vladyslav Povorozniuk
  • Nataliya Dzerovych
  • D. Hans

DOI:

https://doi.org/10.15674/0030-598720152126-136

Keywords:

mark of quality, trabecular bone tissue, age, fractures

Abstract

Osteoporosis is a common systemic disease of the skeleton having significant medical and social consequences. In recent years new diagnostic methods which help to determine the risk and early bone loss in groups of population develop. Thus in 2006 the company «Med-Imaps» (Bordeaux, France) patented a new method «TBS Insight»for assessment the mark of quality of trabecular bone tissue (TBS - trabecular bone score) on the lumbar spine (LI–LIV ). The authors analyzed specific information on using of TBS index in clinical practice. It is proved that age has a significant impact on the variability of TBS index. It was shown correlation between TBS index and  osteoporotic vertebral fractures, femoral neck fractures and fractures in other sites in postmenopausal women. The results of studies of the effect of various drugs on TBS index were presented. The article also presents the results of research carried out on the basis of Ukrainian scientific and medical center of problems of osteoporosis. There was established significant
(p = 0,0003) decline of TBS index (LI–LIV) with age in women living in Ukraine. Significant changes in TBS index (LI–LIV) were observed in women at earlier postmenopausal period – after 4 years or more while changes in bone mineral density were determined in women with postmenopausal duration of 7 years or more. Conclusion: Mark of quality of trabecular bone is independent and has important diagnostic value in analysis of structural and functional state of bone tissue.

References

  1. Osteoporosis: clinical features, diagnosis, prevention and treatment / [Korzh N.A., Povoroznyuk V.V., Dedukh N.V., Zupanets I.A.]. – Kharkov: Golden Pages, 2002. – 468 p.
  2. Povoroznyuk V.V. Trabecular bone score in women depending on duration of postmenopausal period / V.V. Povoroznyuk N.I. Dzerovych // Іmplantologіya. Parodontologіya. Osteologіya. – 2012. – № 4 (28). – P. 12-16.
  3. Povoroznyuk V.V. Trabecular bone score in women of different age / V.V. Povoroznyuk, N.I. Dzerovych // Pain. Joints. Spine. – 2011. – № 4 (04). – P. 29-31.
  4. Povoroznyuk V.V. Bone mineral density and quality, 10-year risk of osteoporotic fractures in Ukrainian men of different ages / V.V. Povoroznyuk, A. Musienko, N.I. Dzerovych // Pain . Joints. Spine. – 2013. – № 3 (11). – P. 52-55.
  5. Povoroznyuk V.V. Menopause and musculoskeletal system / V.V. Povoroznyuk, N.V. Grigorieva. – K., 2004. – 512 p.
  6. A multicentre, retrospective case–control study assessing the role of trabecular bone score (TBS) in menopausal Caucasian women with low areal bone mineral density (BMDa): Ana¬lysing the odds of vertebral fracture / B. Rabier, A. Heraud, C. Grand-Lenoir [et al.] // Bone. — 2010. — Vol. 46 (1). — P. 176–181, doi: 10.1016/j.bone.2009.06.032.
  7. A retrospective case-control study assessing the role of tra¬becular bone score in postmenopausal caucasian women with osteopenia: analyzing the odds of vertebral fracture / R. Win¬zenrieth, R. Dufour, L. Pothuaud, D. Hans // Calcif. Tissue Int. — 2010. — Vol. 86 (2). — P. 104–109, doi: 10.1007/s00223-009-9322-y.
  8. Added value of trabecular bone score to bone mineral density for prediction of osteoporotic fractures in postmenopausal women: the OPUS study / K. Briot, S. Paternotte, S. Kolta [et al.] // Bone. — 2013. — Vol. 57, № 1. — P. 232–236, doi: 10.1016/j.bone.2013.07.040.
  9. Beneficial effect of PTH on spine BMD and microarchitecture (TBS) parameters in postmenopausal women with osteo¬porosis. A 2-year study / B. Gunther, A. W. Popp, D. Stoll [et al.] // Osteoporosis Int. — 2012. — Vol. 23 (Suppl. 2). — P. S332–S333.
  10. Beneficial effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecu¬lar bone score in postmenopausal women with osteoporosis: a three-year study / A. W. Popp, S. Guller, O. Lamy [et al.] // J. Bone Miner. Res. — 2013. — Vol. 28 (3). — P. 449–454, doi: 10.1002/jbmr.1775.
  11. Beneficial effects of strontium ranelate compared to etidro¬nate in postmenopausal osteoporotic women. a 2-year study / D. Hans, M.-A. Krieg, O. Lamy, D. Felsenberg // Osteoporosis Int. — 2012. — Vol. 23 (Suppl. 2). — P. 265–267.
  12. Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study / D. Hans, A. L. Goertzen, M. A. Krieg, W. D. Leslie // J. Bone Miner. Res. — 2011. — Vol. 26, № 11. — P. 2762–2799, doi: 10.1002/jbmr.499.
  13. Cormier C. TBS in routine clinical practice: proposals of use: Atlas of TBS use / C. Cormier, O. Lamy, S. Poriau. — 2012. — 16 p.
  14. Creation of the age-related TBS curve at lumbar spine in US Caucasian women derived from DXA / C. Simonelli, E. Leib, M. McClung [et al.] // J. Clin. Densitom. — 2013. — Vol. 16. — P. 272.
  15. Denosumab significantly improved trabecular bone score (TBS), an index of trabecular microarchitecture, in postmeno¬pausal women with osteoporosis / M. McClung, K. Lippuner, M. Brandi [et al.] // J. Bone Miner Res. — 2012. — Vol. 27 (Suppl. 1). — P. S58–S59.
  16. Effects of antiresorptive agents on bone micro-architecture assessed by TBS in women age 50 and older: The Manitoba prospective study / M. A. Krieg, A. Goertzen, W. D. Leslie, D. Hans // Bone. — 2011. — Vol. 48 (2, Suppl.). — P. 217, doi: 10.1016/j.bone.2011.03.501.
  17. Effects of exemestane and tamoxifen treatment on bone texture analysis assessed by TBS in comparison with bone mineral den¬sity assessed by DXA in women with breast cancer / M. Kalder, D. Hans, I. Kyvernitakis [et al.] // J. Clin. Densitom. — 2014. — Vol. 17 (1). — P. 66–71, doi: 10.1016/j.jocd.2013.03.003.
  18. Effects of zoledronate versus placebo on spine bone min¬eral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: a three-year study / A. W. Popp, S. Guler, O. Lamy [et al.] / J. Bone Miner. Res. — 2013. — Vol. 28 (3). — P. 449–454, doi: 10.1002/jbmr.1775.
  19. European guidance for the diagnosis and management of os¬teoporosis in postmenopausal women / J. A. Kanis, E. V. Mc¬Closkey, H. Johansson [et al.] // Osteoporos Int. — 2013. — Vol. 24, № 1. — P. 23–57, doi: 10.1007/s00198-012-2074-y.
  20. Generation and validation of a normative, age-specific refer¬ence curve for lumbar spine trabecular bone score (TBS) in French women / R. Dufour, R. Winzenrieth, A. Heraud [et al.] // Osteoporos Int. — 2013. — Vol. 24, № 11. — P. 2837–2846, doi: 10.1007/s00198-013-2384-8.
  21. Hans D. Estimation of bone microarchitecture pattern from AP spine DXA scans using the Trabecular Bone Score (TBS): an added value in clinical routine for the patient. A short review / D. Hans, R. Winzenrieth // Osteologicky bulletin. — 2011. — Vol. 16 (3). — P. 70–78.
  22. Holroyd C. Epidemiology of osteoporosis / C. Holroyd, C. Cooper, E. Dennison // Best Pract. Res. Clin. Endocrinol. Metab. — 2008. — Vol. 22, № 5. — P. 671–685.
  23. Influence of age, morphological characteristics, and lumbar spine bone mineral density on lumbar spine trabecular bone score in Lebanese women / R. El Hage, W. Khairallah, F. Ba¬chour [et al.] // J. Clin. Densitom. — 2014. — Vol. 17, № 3. — P. 434–435, doi: 10.1016/j.jocd.2013.03.012.
  24. Is bone microarchitecture status of the lumbar spine assessed by TBS related to femoral neck fracture? A Spanish case-control study / L. M. Del Rio, R. Winzenrieth, C. Cormier, S. Di Gregorio // Osteoporos Int. — 2013. — Vol. 24, № 3. — P. 991–998, doi: 10.1007/s00198-012-2008-8.
  25. Johnell O. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures / O. Johnell, J. A. Kanis // Osteoporos Int. — 2006. — Vol. 17, № 12. — P. 1726–1733.
  26. Laplante B. L. Spine osteoarthritis. Review / B. L. Laplante, M. J. DePalma // PM R. — 2012. — Vol. 4 (Suppl. 5). — P. S28–S36, doi: 10.1016/j.pmrj.2012.03.005.
  27. Leslie W. D. Clinical factors associated with trabecular bone score / W. D. Leslie, M. A. Krieg, D. Hans // J Clin Densi¬tom. — 2013. — Vol. 16, № 3. — P. 374–379, doi: 10.1016/j.jocd.2013.01.006.
  28. Leslie W. D. Lumbar spine TBS is a FRAX independent risk factor for fracture. The Manitoba BMD Cohort / W. D. Leslie, J. Kanis: abstract books of ISCD Annual meeting, Tampa, Florida, 2013.
  29. Lorenc R. TBS as a predictor of vertebral fracture in Polish men / R. Lorenc, W. Horst-Sikorska // J. Bone Miner. Res. — 2012. — Vol. 27 (Suppl. 1) — P. 487.
  30. Pothuaud L. Evaluation of the potential use of trabecular bone score to complement bone mineral density in the diagnosis of osteoporosis: a preliminary spine BMD-matched, Case-control study / L. Pothuaud, N. Barthe, M.-A. Krieg // J. Clin. Densi¬tom. — 2009. — Vol. 12, № 2. — P. 170–176, doi: 10.1016/j.jocd.2008.11.006.
  31. Spine trabecular bone score subsequent to bone mineral den¬sity improves fracture discrimination in women / D. Krueger, E. Fidler, J. Libber [et al.] // J. Clin. Densitom. — 2014. — Vol. 17, № 1. — P. 60–65, doi: 10.1016/j.jocd.2013.05.001.
  32. The OsteoLaus Cohort Study: bone mineral density, microar¬chitecture score and vertebral fracture assessment extracted from a single DXA device in combination with clinical risk factors improve significantly the identification of women at high risk of fracture / O. Lamy, M.-A. Krieg, D. Stoll [et al.] // Osteologie. — 2012. — Vol. 21. — P. 77–82.
  33. The predictive value of trabecular bone score (TBS) on whole lumbar vertebrae mechanics: an ex vivo study / J. P. Roux, J. We¬grzyn, S. Boutroy [et al.] // Osteoporos. Int. — 2013. — Vol. 24, № 9. — P. 2455–2460, doi: 10.1007/s00198-013-2316-7.
  34. Trabecular bone score (TBS) — a novel method to evaluate bone microarchitectural texture in patients with primary hy¬perparathyroidism / B. C. Silva, S. Boutroy, C. Zhang [et al.] // J. Clin. Endocrinol. Metab. — 2013. — Vol. 98, № 5. — P. 1963–1970, doi: 10.1210/jc.2012-4255.
  35. Trabecular bone score (TBS) predicts vertebral fractures in Japanese women over 10 years independently of bone density and prevalent vertebral deformity: the Japanese population-based osteoporosis (JPOS) cohort study / M. Iki, J. Tamaki, E. Kadowaki [et al.] // J. Bone Miner. Res. — 2014. — Vol. 29, № 2. — P. 399–407, doi: 10.1002/jbmr.2048.
  36. Trabecular bone score (TBS): an indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism / E. Romagnoli, C. Cipriani, I. Nofroni [et al.] // Bone. — 2013. — Vol. 53, № 1. — P. 154–159, doi: 10.1016/j.bone.2012.11.041.
  37. Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study / S. Boutroy, D. Hans, E. Sornay-Rendu [et al.] // Osteoporos. Int. — 2013. — Vol. 24, № 1. — P. 77–85, doi: 10.1007/s00198-012-2188-2.
  38. Trabecular bone score is associated with volumetric bone density and microarchitecture as assessed by central QCT and HRpQCT in Chinese American and white women / B. C. Silva, M. D. Walker, A. Abraham [et al.] // J. Clin. Densi¬tom. — 2013. — Vol. 16, № 4. — P. 554–561, doi: 10.1016/j.jocd.2013.07.001.
  39. Trabecular bone score: a noninvasive analytical method based upon the DXA image / B. C. Silva, W. D. Leslie, H. Resch [et al.] // J. Bone Mineral Res. — 2014. — Vol. 29, № 3. — P. 518–530, doi: 10.1002/jbmr.2176.
  40. Vertebral microarchitecture and fragility fracture in men: a TBS study / E. Leib E., B. Aubry-Rozier, R. Winzenri¬eth, D. Hans // Bone. — 2014. — Vol. 62. — P. 51–55, doi: 10.1016/j.bone.2013.12.015.
  41. Winzenrieth R. Three-dimensional (3D) microarchitecture correlations with 2D projection image gray-level variations assessed by trabecular bone score using high-resolution computed tomographic acquisitions: effects of resolution and noise / R. Winzenrieth, F. Michelet, D. Hans // J. Clin. Densi¬tom. — 2013. — Vol. 29, № 3. — P. 287–296, doi: 10.1016/j.jocd.2012.05.001.

Downloads

How to Cite

Povorozniuk, V., Dzerovych, N., & Hans, D. (2015). Trabecular bone score in clinical practice (review). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 126–136. https://doi.org/10.15674/0030-598720152126-136

Issue

No. 2 (2015)

Section

DIGESTS AND REVIEWS

License

Copyright (c) 2015 Vladyslav Povoroznyuk, Nataliya Dzerovych, D. Hans

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).