Role of vitamin D in formation of vertebral pain in women in postmenopausal period depending of bone mineral density

Vladyslav Povorozniuk, Tatyana Orlik, Nataliya Balatska, V. Mutz

Abstract


Objective:  To  investigate  the relationship  between  the  level of 25(OH)D in blood serum and characteristics of vertebral pain

in older women depending on the bone mineral density (BMD). Methods: The study involved 178 postmenopausal women aged

from 50 to 79 years. Patients were divided into groups depending on the level of 25 (OH) D in blood serum (less than 25, 25–50,

50 nmol/l) and BMD (osteoporosis, osteopenia, norm). Vertebral pain  was  assessed  with  using  of  a  visual  analog  scale.  Level 25(OH)D in the blood serum was analyzed by elektrokhemiluminiscent method. BMD was measured at the lumbar spine (LI–LIV) using dual-energy X-ray densitometer. Results: It was found that the frequency and intensity of pain in the thoracic spine in women of older age groups with different state of BMD (osteoporosis, osteopenia, the norm) does not depend on the level of 25(OH)D in blood serum. Frequency of pain in the lumbar spine is significantly higher in patients with low levels of 25(OH)D in blood serum  (deficiency  and  insufficiency)  regardless  of  BMD  state. Decreasing of BMD indicators (osteoporosis and osteopenia) do not change the risk of vertebral pain against the background of the unsatisfactory status of vitamin D but increase its expression in the lumbar spine. Conclusion: The expression of lumbar spine pain in older women with systemic osteoporosis and osteopenia linked to the level of 25(OH)D in blood serum which substantiate the  feasibility  of  its  screening  examination  in  this  category  of patients.


Keywords


Key words: pain; back; vitamin D; osteoporosis; BMD women; postmenopause

References


Deficiency of vitamin D insufficiency and epidemiology, diagnosis, prevention and treatment / edited. prof.Povoroznyuka V., prof. Pludovskoho AP - CUP "Ex-Press", 2014. — 250 с.

Al Faraj S. Vitamin D deficiency and chronic low back pain in Saudi Arabia / Al Faraj S., Al Mutairi K. // Spine. — 2003. — Vol. 28 (2). — Р. 177–179.

Association between nonspecific skeletal pain and vitamin D deficiency / B. Heidari, J. S. Shirvani, A. Firouzjahi [et al.] // Int. J. Rheum. Dis. — 2010. — Vol. 13(4). — Р. 340–346, doi: 10.1111/j.1756-185X.2010.01561.x.

Bone density in chronic low back pain: a pilot study / T. A. Gaber, K. A. McGlashan, S. Love [et al.] // Clin. Rehabil. — 2002. — Vol. 16. — Р. 867–870.

Bone mineral density is not associated with musculoskeletal pain in postmenopausal Korean women aged ≥50 years / K. M. Lee, C. Y. Chung, S. S. Kwon [et al]. // Clin. Rheumatol. — 2015. — Vol. 34(2). — P. 337–343, doi: 10.1007/s10067-014-2790-0.

Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide ntagonist / R. Ambalavanar, M. Moritani, A. Moutanni [et al.] // Pain. — 2006. — Vol. 120 (1–2). — Р. 53–68.

Defrin R. Gender role expectations of pain is associated with pain tolerance limit but not with pain threshold / R. Defrin, L. Shramm, I. Eli // Pain. — 2009. — Vol. 145 (1–2). — Р. 230–236, doi: 10.1016/j.pain.2009.06.028.

Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline / M. F. Holick, N. Binkley, H. Bischoff-Ferrari [et al.] // J. Clin. Endocrin. Metab. — 2011. — Vol. 96 (7). — P. 1911–1930, doi: 10.1210/jc.2011-0385.

Hypovitaminosis D in female patients with chronic low back pain / A. Lotfi, A. M. Abdel-Nasser, A. Hamdy [et al.] // Clin. Rheumatol. — 2007. — Vol. 26 (11). — Р. 1895–1901.

Leavitt S. B. Vitamin D — a neglected ‘analgesic for chronic musculoskeletal pain [electronic resource] / S. B. Leavitt // Pain Treatment Topics. — 2008. — Accesses to document: http://pain-topics.org/pdf/vitamind-report.pdf.

Low back pain associated with sociodemographic factors, lifestyle and osteoporosis: a population-based study / Y. C. Chou, C. C. Shih, J. G. Lin [et al.] // J. Rehabil. Med. — 2013. — Vol. 45 (1). — Р. 76–80, doi: 10.2340/16501977-1070.

Mascarenhas R. Hypovitaminosis D-induced pain / R. Mascarenhas, S. Mobarhan // Nutr. Rev. — 2004. — Vol. 62. — Р. 354–359.

Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study / J. McBeth, S. R. Pye, T. W. O’Neill [et al.] // Ann. Rheum. Dis. — 2010. — Vol. 69(8). — Р. 1448–1452, doi: 10.1136/ard.2009.116053.

Osteoporosis prevention, diagnosis and therapy / NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy // JAMA. — 2001. — 285 (6). — Р. 785–795.

Persistent limb pain and raised serum alkaline phosphatase the earliest markers of subclinical hypovitaminosis D in Kashmir / H. Masood, A. P. Narang, I. A. Bhat, G. N. Shah // Indian J. Physiol Pharmacol. — 1989. — Vol. 33. — Р. 259–261.

Plotnikoff G. A. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain / G. A. Plotnikoff, J. M. Quigley // Mayo Clin Proc. — 2003. — Vol. 78. — Р. 1463–1470.

Sedrine W. B. On conducting burden-of-osteoporosis studies: a review of the core concepts and practical issues. A study carried out under the auspices of a WHO Collaborating Center / W. B. Sedrine, L. Radican, J. Y. Reginster // Rheumatology. — 2001. — Vol. 40. — Р. 7–14.

Skyba D. A. Characterization of a method for measuring

primary hyperalgesia of deep somatic tissue / D. A. Skyba, R. Radhakrishnan, K. A. Sluka // J. Pain. — 2005. — Vol. 6. — Р. 41–47.

The prevalence of vitamin D deficiency in consecutive new patients seen over a 6-month period in general rheumatology clinics / M. Haroon, U. Bond, N. Quillinan [et al.] // Clin Rheumatol. — 2011. — Vol. 30 (6). — Р. 789–794, doi: 10.1007/s10067-010-1659-0.

Vitamin D insufficiency: implications for the immune system / F. Baeke, C. Gysemans, H. Korf, C. Mathieu // Pediatr Nephrol. — 2010. — Vol. 25(9). — Р. 1597–1606, doi: 10.1007/s00467-010-1452-y.




DOI: https://doi.org/10.15674/0030-59872015158-62

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