STUDY OF THE POTENTIAL ANALGESIC PROPERTIES OF CARBON DIOXIDE FOR THE TREATMENT OF PAIN SYNDROME IN CASE OF OSTEOARTHRITIS

Authors

DOI:

https://doi.org/10.15674/0030-59872024370-75

Keywords:

Carbon dioxide, carboxytherapy, pain assessment, inflammation, pain, osteoarthritis, chondroitin, диклофенак

Abstract

Pain syndrome is a serious global problem that causes and complicates a number of diseases, the main symptom of which is joint pain. One of them is osteoarthritis (OA). Traditional methods of treating OA often have limited efficacy and can cause side effects, so it is important to study new approaches, such as carboxytherapy (use of carbon dioxide). Objective. To investigate the analgesic effect of carbon dioxide (CO2) and its combined use with other agents. Methods. The efficacy of carbon dioxide injections used alone and in combination with other drugs was studied in a formalin model of inflammation in rats. Results. The latent periods of phases I and II increased significantly in the experimental groups, especially in groups V, VI and VII (p < 0.001), indicating a delay in pain reactions. The duration of pain phase I was significantly shorter in the groups receiving CO2 compared to the control group (p < 0.001). The shortest duration was observed in group V, where it decreased by 1.77 minutes. The duration of pain phase II was also significantly shorter in groups V, VI, and VII treated with CO2 compared to group II (p < 0.001). The difference ranged from 7.49 to 12.54 minutes. The number of pain reactions after phase I decreased by 13.25– 16.1 points in the groups receiving CO2 compared to the control group. The data obtained indicate that CO2 significantly increases the duration of latent periods of pain (by 55–65 %), reduces the duration of its phases (by 40–50 %) and reduces the intensity of pain reactions (by 40–50 %) in rats compared to control pathology. The most pronounced effect was observed with the combined use of CO2 with sodium diclofenac or chondroitin sulfate. Conclusions. The results of the study expand the understanding of the analgesic effect of CO2 on the formalin model of inflammation. The use of CO2 significantly reduced the duration of both phases of the pain reaction and reduced the number of painful manifestations, which confirms the prospects of its use as an additional, and in some cases the main means of reducing pain and inflammation.

Author Biographies

Viktor Shtroblia, Uzhhorod National University. Ukraine

MD

Ruslan Lutsenko, Poltava State Medical University. Ukraine

MD, Prof.

References

  1. Saengsiwaritt, W., Ngamtipakon, P., & Udomsinprasert, W. (2023). Vitamin D and autophagy in knee osteoarthritis: A review. International immunopharmacology, 123, 110712. https://doi.org/10.1016/j.intimp.2023.110712
  2. Latourte, A., Kloppenburg, M., & Richette, P. (2020). Emerging pharmaceutical therapies for osteoarthritis. Nature reviews. Rheumatology, 16(12), 673–688. https://doi.org/10.1038/s41584-020-00518-6
  3. Yao, X., Sun, K., Yu, S., Luo, J., Guo, J., Lin, J., Wang, G., Guo, Z., Ye, Y., & Guo, F. (2020). Chondrocyte ferroptosis contribute to the progression of osteoarthritis. Journal of orthopaedic translation, 27, 33–43. https://doi.org/10.1016/j.jot.2020.09.006
  4. Geng, R., Li, J., Yu, C., Zhang, C., Chen, F., Chen, J., Ni, H., Wang, J., Kang, K., Wei, Z., Xu, Y., & Jin, T. (2023). Knee osteoarthritis: Current status and research progress in treatment (Review). Experimental and therapeutic medicine, 26(4), 481. https://doi.org/10.3892/etm.2023.12180
  5. Yu, H., Huang, T., Lu, W. W., Tong, L., & Chen, D. (2022). Osteoarthritis Pain. International journal of molecular sciences, 23(9), 4642. https://doi.org/10.3390/ijms23094642
  6. Quicke, J. G., Conaghan, P. G., Corp, N., & Peat, G. (2022). Osteoarthritis year in review 2021: epidemiology & therapy. Osteoarthritis and cartilage, 30(2), 196–206. https://doi.org/10.1016/j.joca.2021.10.003
  7. Lutsenko R.V. Moisieieva N.V., Sydorenko A.H.Ostrovska H.Yu. Kapustianska A.A. (2023) Ways to promote the efficiency of herpetic stomatitis treatment. Medicni Perspektiv, 28, (2), 71-76. https://doi.org/10.26641/2307-0404.2023.2.283255
  8. Kroumpouzos, G., Arora, G., Kassir, M., Galadari, H., Wollina, U., Lotti, T., Grabbe, S., & Goldust, M. (2022). Carboxytherapy in dermatology. Clinics in dermatology, 40(3), 305–309. https://doi.org/10.1016/j.clindermatol.2021.08.020
  9. Amano-Iga, R., Hasegawa, T., Takeda, D., Murakami, A., Yatagai, N., Saito, I., Arimoto, S., Kakei, Y., Sakakibara, A., & Akashi, M. (2021). Local Application of Transcutaneous Carbon Dioxide Paste Decreases Inflammation and Accelerates Wound Healing. Cureus, 13(11), e19518. https://doi.org/10.7759/cureus.19518
  10. Yatagai, N., Hasegawa, T., Amano, R., Saito, I., Arimoto, S., Takeda, D., Kakei, Y., & Akashi, M. (2021). Transcutaneous Carbon Dioxide Decreases Immunosuppressive Factors in Squamous Cell Carcinoma In Vivo. BioMed research international, 2021, 5568428. https://doi.org/10.1155/2021/5568428
  11. Oda, T., Iwakura, T., Fukui, T., Oe, K., Mifune, Y., Hayashi, S., Matsumoto, T., Matsushita, T., Kawamoto, T., Sakai, Y., Akisue, T., Kuroda, R., & Niikura, T. (2020). Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5), 886–891. https://doi.org/10.1016/j.jos.2019.09.017
  12. Seirafianpour, F., Atefi, N., Amin, N. G., Namazi, M. R., Behrangi, E., Shafiei, A., Ghassemi, M., Mozafarpoor, S., & Goodarzi, A. (2024). Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 30(3), e13651. https://doi.org/10.1111/srt.13651
  13. Bamps, D., Vriens, J., de Hoon, J., & Voets, T. (2021). TRP Channel Cooperation for Nociception: Therapeutic Opportunities. Annual review of pharmacology and toxicology, 61, 655–677. https://doi.org/10.1146/annurev-pharmtox-010919-023238
  14. Vincent T. L. (2020). Peripheral pain mechanisms in osteoarthritis. Pain, 161 Suppl 1(1), S138–S146. https://doi.org/10.1097/j.pain.0000000000001923
  15. Stöckl, S., Eitner, A., Bauer, R. J., König, M., Johnstone, B., & Grässel, S. (2021). Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes. Frontiers in immunology, 12, 722884. https://doi.org/10.3389/fimmu.2021.722884
  16. López-Cano, M., Fernández-Dueñas, V., Llebaria, A., & Ciruela, F. (2017). Formalin Murine Model of Pain. Bio-protocol, 7(23), e2628. https://doi.org/10.21769/BioProtoc.2628
  17. Rivers, R. J., & Meininger, C. J. (2023). The Tissue Response to Hypoxia: How Therapeutic Carbon Dioxide Moves the Response toward Homeostasis and Away from Instability. International journal of molecular sciences, 24(6), 5181. https://doi.org/10.3390/ijms24065181
  18. Dumbill, R., Rabcuka, J., Fallon, J., Knight, S., Hunter, J., Voyce, D., Barrett, J., Ellen, M., Weissenbacher, A., Kurniawan, T., Blonski, S., Korczyk, P. M., Ploeg, R., Coussios, C., Friend, P., & Swietach, P. (2024). Impaired O2 unloading from stored blood results in diffusion-limited O2 release at tissues: evidence from human kidneys. Blood, 143(8), 721–733. https://doi.org/10.1182/blood.2023022385
  19. Iordanishvili, A. K., Soldatova, L. N., & Muzikin, M. I. (2023). Carboxytherapy for the elimination of pain symptoms (or arthralgia) among the elderly persons with the pathology of the temporomandibular joint. Advances in gerontology = Uspekhi gerontologii, 36(2), 251–255.
  20. Lopes Machado, C., Lopes Machado, M., & Lourenço Lopes, L. (2022). Analgesic Effect of Carboxytherapy for Postoperative Neuropathic Facial Pain: A Case Report. Cureus, 14(6), e26301. https://doi.org/10.7759/cureus.26301
  21. Ratano, S., Jovanovic, B., & Ouabo, E. C. (2023). Effects of the Percutaneous Carbon Dioxide Therapy on Post-surgical and Post-traumatic Hematoma, Edema and Pain. Journal of orthopaedic case reports, 13(12), 11–17. https://doi.org/10.13107/jocr.2023.v13.i12.4058
  22. Macura, M., Ban Frangez, H., Cankar, K., Finžgar, M., & Frangez, I. (2020). The effect of transcutaneous application of gaseous CO2 on diabetic chronic wound healing-A double-blind randomized clinical trial. International wound journal, 17(6), 1607–1614. https://doi.org/10.1111/iwj.13436

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How to Cite

Shtroblia, V. ., & Lutsenko, R. . (2024). STUDY OF THE POTENTIAL ANALGESIC PROPERTIES OF CARBON DIOXIDE FOR THE TREATMENT OF PAIN SYNDROME IN CASE OF OSTEOARTHRITIS. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 70–75. https://doi.org/10.15674/0030-59872024370-75

Issue

No. 3 (2024)

Section

ORIGINAL ARTICLES

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