BIOCHEMICAL MARKERS OF BLOOD SERUM AND ARTICULAR CARTILAGE IN DIFFERENT FORMS OF IDIOPATHIC COXARTHROSIS PROGRESSION

Authors

  • Sadrudin Magomedov SI «Institute of Traumatology and Orthopedics of the National Academy of Sciences of Ukraine», Kyiv, Ukraine
  • Oleksiy Kalashnikov SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv, Ukraine
  • Larisa Polishchuk SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv, Ukraine
  • Taisiya Kuzub SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv, Ukraine
  • Volodymyr Zayets SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.15674/0030-59872023443-47

Keywords:

Coxarthrosis, biochemical changes, stages of progression, blood serum, articular cartilage

Abstract

Deformation due to arthrosis of the hip joint affects 40 % of the total number of patients with osteoarthritis, which is from 7 to 25 % of the adult population. For the activity of the pathological process evaluation we studied biochemical changes in the metabolism of collagen, namely: glycosaminoglycans (GAG), hydroxyproline (HP) fractions, collagenase, hyaluronidase activity, etc. Objective. To determine the biochemical changes in blood serum and articular cartilage depending on the form of progression of idiopathic coxarthrosis. Methods. 23 patients were examined (8 (34.8 %) men, 15 (65.2 %) women, age 45‒75 years and more) with idiopathic arthrosis of the hip joint IV stage (Kellgren–Lawrence). Progression forms of idiopathic coxarthrosis were distinguished: group I — rapid (the period from the initial to the final stage of the disease was 5 years and less), II — moderate (5‒10 years), III — slow (over 10 years). Collagenase activity, HP fractions, total GAG content were determined in patients’ blood serum, and collagen content was determined in the cartilage tissue of the femoral head. Results. Compared with the age reference norm in the blood serum of patients of group I activity collagenase increased to 114 %, in II and III — 122 and 135 %, respectively; the content of the free fraction of GP — up to 111, 169, 128 %, respectively; GAG concentrations — up to 110, 122, and 135 %, respectively; protein-bound HP was reduced to 60% in group II, up to 84 % — in group III. In cartilage tissue, the GAG content decreased in group III to 63 %, II — 55 %, I — 47 %; collagen — 32, 25, 24 % in accordance. Conclusions. The course of idiopathic coxarthrosis is determined by metabolic changes in the components of the organic basis of connective and cartilaginous tissues in blood serum. The most profound changes were found in the synthetic phase of HP metabolism, especially in the group with a rapid course disease. A decrease in the content of organic components of connective tissue (GAG and collagen) was determined

Author Biographies

Sadrudin Magomedov, SI «Institute of Traumatology and Orthopedics of the National Academy of Sciences of Ukraine», Kyiv

MD, Prof.

Oleksiy Kalashnikov, SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv

Doctor of Traumatology and Orthopaedics

Volodymyr Zayets, SI «Institute of Traumatology and Orthopaedics of the NAMS of Ukraine», Kyiv

MD, PhD

References

  1. Zengini, E., Finan, C., & Wilkinson, J. M. (2016). The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going? The Journal of Rheumatology, 43 (2), 260–266. https://doi.org/10.3899/jrheum.150710
  2. Park, J., Mendy, A., & Vieira, E. R. (2018). Various Types of Arthritis in the United States: Prevalence and Age-Related Trends From 1999 to 2014. American Journal of Public Health, 108 (2), 256–258. https://doi.org/10.2105/ajph.2017.304179
  3. Kim, J.-R., Yoo, J., & Kim, H. (2018). Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis. International Journal of Molecular Sciences, 19 (3), 674. https://doi.org/10.3390/ijms19030674
  4. Kapoor, M. & Mahomed, N. N. (2015). Osteoarthritis: Pathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative and Precision Medicine. Springer International Publishing.
  5. Alekseeva, L. I., Taskina, E.A. & Kashevarova, N.G. (2019). Osteoarthritis: epidemiology, classification, risk factors and progression, clinic, diagnosis, treatment. Modern rheumatology, 13 (2), 9–21. (in russian)
  6. Bannuru, R. R., Osani, M. C., Vaysbrot, E. E., Arden, N. K., Bennell, K., Bierma-Zeinstra, S. M. A., Kraus, V. B., Lohmander, L. S., Abbott, J. H., Bhandari, M., Blanco, F. J., Espinosa, R., Haugen, I. K., Lin, J., Mandl, L. A., Moilanen, E., Nakamura, N., Snyder-Mackler, L., Trojian, T., ... McAlindon, T. E. (2019). OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage, 27 (11), 1578–1589. https://doi.org/10.1016/j.joca.2019.06.011
  7. Vannabouathong, C., Bhandari, M., Bedi, A., Khanna, V., Yung, P., Shetty, V., & Khan, M. (2018). Nonoperative Treatments for Knee Osteoarthritis: An Evaluation of Treatment Characteristics and the Intra-Articular Placebo Effect. JBJS Reviews, 6 (7), e5–e5. https://doi.org/10.2106/jbjs.rvw.17.00167
  8. Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt,G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., Gellar, K., Harvey, W. F., Hawker, G., Herzig, E., Kwoh, C. K., Nelson, A. E., Samuels, J., Scanzello, C., White, D., ... Reston,J. (2020). 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis & Rheumatology, 72 (2), 220–233. https://doi.org/10.1002/acr.24131
  9. Gayko, G. V. & Kalashnikov, O. V. (2014). Osteoarthritis of the hip: factors of occurrence and progression, treatment and prevention. Scientific journal of the Ministry of Health of Ukraine, 5 (1), 70–77. (in Ukrainian)
  10. Vannabouathong, C., Bhandari, M., Bedi, A., Khanna, V., Yung, P., Shetty, V., & Khan, M. (2018b). Nonoperative Treatments for Knee Osteoarthritis: An Evaluation of Treatment Characteristics and the Intra-Articular Placebo Effect. JBJS Reviews, 6 (7), e5-e5. https://doi.org/10.2106/jbjs.rvw.17.00167
  11. Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J.-P. (2016). Osteoarthritis. Nature Reviews Disease Primers, 2 (1). https://doi.org/10.1038/nrdp.2016.72
  12. Salman, L. A., Ahmed, G., Dakin, S. G., Kendrick, B., & Price, A. (2023). Osteoarthritis: a narrative review of molecular approaches to disease management. Arthritis Research & Therapy, 25 (1). https://doi.org/10.1186/s13075-023-03006-w
  13. Shah, N., Jadidi, S., & Bajaj, P. S. (2021). A Review of Non-Surgical Pain Management in Osteoarthritis. Cureus, 13 (7), 45. https://doi.org/10.7759/cureus.c45
  14. Slutsky, L. I. (1969). Biochemistry of normal and pathologically altered connective tissue. L.: Medicine. (in russian)
  15. Klyatskin, S. A. & Lifshits, R. I. (1989). Determination of glycosaminoglycans by the orcin method in the blood of patients. Lab. case., 10, 51–53. (in russian)
  16. Kellgren, J. H., & Lawrence, J. S. (1957). Radiological Assessment of Osteo-Arthrosis. Annals of the Rheumatic Diseases, 16 (4), 494–502. https://doi.org/10.1136/ard.16.4.494
  17. Yasuda, T., Matsunaga, K., Hashimura, T., Tsukamoto, Y., Sueyoshi, T., Ota, S., Fujita, S., & Onishi, E. (2020). Characterization of rapidly progressive osteoarthritis of the hip in its early stage. European Journal of Rheumatology, 7 (3), 130–134. https://doi.org/10.5152/eurjrheum.2020.19159
  18. Zazgyva, A., Gurzu, S., Gergely, I., Jung, I., Roman, C. O., & Pop, T. S. (2017). Clinico-radiological diagnosis and grading of rapidly progressive osteoarthritis of the hip. Medicine, 96 (12), e6395. https://doi.org/10.1097/md.0000000000006395
  19. Morimoto, T., Kitajima, M., Tsukamoto, M., Yoshihara, T., Sonohata, M., & Mawatari, M. (2017). Sagittal spino-pelvic alignment in rapidly destructive coxarthrosis. European Spine Journal, 27 (2), 475–481. https://doi.org/10.1007/s00586-017-5282-5
  20. Lindy, S., Halme, J., Turto, H., Rokkanen, P., Vainio, K., & Wegelius, O. (1973). Collagenolytic activity in rheumatoid synovial tissue. Clinica Chimica Acta, 47 (2), 153–157. https://doi.org/10.1016/0009-8981(73)90310-0
  21. Frey, S. (1965). Etude d'unemethoded'exploration et du taux normal de I'hydroxproline du serum. Biochem., Biophys., 3 (2), 446–450.
  22. Stegemann, H. J. (1952). A simple procedure for the determination of hydroxyproline in urine and bone. Biochemical medicine, 3 (1), 23–30.
  23. Krylov, A. A. & Katz, A. M. (1981). Guidelines for laboratory assistants of clinical diagnosti c laboratories. L., Medicine. (in russian)
  24. Katnic, I., & Orlandic, M. (2020). Fundamentals of Biomedical Statistics. Stud Health Technol Inform, 274, 111–121. https://doi.org/10.3233/SHTI200671

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How to Cite

Magomedov, S. ., Kalashnikov, O. ., Polishchuk, L. ., Kuzub, T., & Zayets, V. . (2024). BIOCHEMICAL MARKERS OF BLOOD SERUM AND ARTICULAR CARTILAGE IN DIFFERENT FORMS OF IDIOPATHIC COXARTHROSIS PROGRESSION. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 43–47. https://doi.org/10.15674/0030-59872023443-47

Issue

No. 4 (2023)

Section

ORIGINAL ARTICLES

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