Effect of «Osteogenon» on bone mineral density and dynamics of pain in patients with rheumatoid arthritis

Authors

  • Olexandr Kuryata
  • Ilona Karavanska
  • Tetyana Lysunets
  • Iryna Garmish

DOI:

https://doi.org/10.15674/0030-59872014258-62

Keywords:

rheumatoid arthritis, osteopenia, bone mineral density, treatment

Abstract

Rheumatoid arthritis ( RA) accompanied by extension of local (periarticular) osteopenia and of generalized bone loss. Patients with RA require prevention of osteoporosis the first basic drugs of which is calcium and vitamin D3. Objective: to evaluate bone mineral density (BMD) in patients with RA and dynamics of pain on the background of treatment with «Osteogenon» comparing with a combination of calcium / vitamin D. 47 patients with RA were divided into two groups. Patients of the first group obtained basic therapy and «Osteogenon», and of the second one — basic therapy and calcium with vitamin D. Results: pain decreased on 35,4 % (p < 0,05) and on 9,1 % (p < 0,05) in the first group and second one, respectively, after 6 months. BMD increased in patients of the first group on 4,13 % (p < 0,01) after 6 months, probable positive dynamics was not registered in patients of the second group. Significant increasing of BMD was observed in patients of the first group comparing with those who obtained standard combination of calcium carbonate with vitamin D at recommended doses.

References

  1. Pharmacotherapy of osteoporosis: the possibility of using bisfofonatov / E. L. Nasonov, I. A. Skripnikova, L. I. Benevolenskaya, V. A. Nasonova // Clinical Medicine. — 1996. — № 9. — Р. 16-22.
  2. Rozhinskaya L. Y. Systemic osteoporosis: a practical guide for physicians / L. Y. Rozhinskaya // Publisher Mokeev, 2000. — 195 р.
  3. Lesnyak O. M. Clinical recommendations. Osteoporosis. Diagnosis, Prevention and Treatment / O. M. Lesnyak, L. I. Benevolenskaya. — M.: GEOTAR Media, 2010. — 272 р.
  4. Nasonov E. L. The glucocorticoid osteoporosis: current recommendations / E. L. Nasonov // Consiliummedicum, 2002. — № 4. — Р. 8.
  5. Povoroznyuk V. V. Modern principles of prevention and treatment of osteoporosis and osteoarthritis / V. V. Povoroznyuk, N. V. Grigorieva, N. I. Shpilev // Newspaper "News of medicine and pharmacy." — 2008. — № 19 (261). — P. 8-10.
  6. Kuryata O. V. Peculiarities of chronic pain in inflammatory joint diseases and the effectiveness of pain control for background correction anxiety-disorders dypresyvnyh / O. V. Kuryata, O. Noda, T. K. Lysunets // Ukrainian Journal of Rheumatology. — 2012. — № 48 (2). — Р. 14-18.
  7. Toroptsova N. V. Osteoporosis clinical guidelines / N. V. Toroptsova, L. I. Benevolenskaya, O. A. Nikitinskaya // Journal of the attending physician. — 2006. — № 10. — Р. 5-7.
  8. Povoroznyuk V. V. The pain syndrome with osteoporosis and methods of its correction / V. V. Povoroznyuk, N. V. Grigorieva // Рain. Joints. Spine. — 2011. — № 1 (01). — Р. 7-10.
  9. The Ministry of Health Ukraine of 12.10.2006 № 676 clinical protocols of care for patients with rheumatoid arthritis (RA).
  10. Dambacher M. A. Anamnesis and diagnostic course in osteoporosis patients and in patients at risk / M. A. Dambacher, H. Bröll // Ther. Umsch. — 1991. — Vol. 48 (2). — P. 66–76.
  11. Fluoride salts are no better at preventing new vertebral fractures than calcium-vitamin D in postmenopausal osteoporosis: the FAVOStudy / P. J. Meunier, J. L. Sebert, J. Y. Reginster [et al.] // Osteoporosis Int. — 1998. — Vol. 8 (1). — P. 4–12.
  12. Generalised bone loss in patients with early rheumatoid arthritis / A. K. Gough, J. Lilley, S. Eyre [et al.] // Lancet. — 1994. — Vol. 344 (8914). — P. 23–27.
  13. Brosch S. Pathogenesis of osteoporosis in rheumatoid arthritis / S. Brosch, K. Redlich, P. Pietschmann // Acta Med. Austriaca. — 2003. — Vol. 30 (1). — P. 1–5.

How to Cite

Kuryata, O., Karavanska, I., Lysunets, T., & Garmish, I. (2014). Effect of «Osteogenon» on bone mineral density and dynamics of pain in patients with rheumatoid arthritis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 58–62. https://doi.org/10.15674/0030-59872014258-62

Issue

Section

ORIGINAL ARTICLES