Molecular hydrogen as a possible therapeutic factor in complex rehabilitation therapy in patients with muscular skeletal disorders (literature review)

Authors

  • Vasyl Makolinets Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine https://orcid.org/0000-0002-1954-365X
  • Tamara Grashenkova Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • Volodymyr Moseichuk «Chemtest Ukraine+» LTD, Kharkiv, Ukraine
  • Kyrylo Makolinets Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • Vladyslav Moseichuk «Chemtest Ukraine+» LTD, Kharkiv, Ukraine

DOI:

https://doi.org/10.15674/0030-59872021192-97

Keywords:

Molecular hydrogen, hydrogen water, hydrogen inhalations, joint diseases, consequences of musculoskeletal injuries, comorbid pathology

Abstract

The paper presents an analysis of foreign scientific and medical data on the therapeutic factor — molecular hydrogen. The effectiveness of its application in the complex therapy of many diseases is revealed. The effect is achieved due to the small size of the mo­lecule, which passes through biological membranes and inhibits dangerous free radicals in the mitochondria, as well as in the nuc­leus, which reduces the possibility of DNA damaging. Molecular hydrogen neutralizes oxidants in the brain due to its ability to cross the blood-brain barrier. It normalizes the functions and metabolic processes in the body and, as an antioxidant, is selective: it does not affect the useful free radicals involved in important metabo­lic processes and selectively eliminates only the most dangerous oxidants — hydroxyl radicals. Interacting with them, hydrogen converts them into water molecules without the formation of by-products and chain reactions. Unlike other known antioxidants, molecular hydrogen does not disrupt normal metabolism, does not cause negative changes in cells, activates the body’s own anti­oxidant systems. The possibility and expediency of the use of molecular hydrogen in the case of pathology of the musculoskeletal system has been confirmed. The peculiarities of its effect on bone and cartilage tissue in the experiment are shown. It has been determined that the use of molecular hydrogen is a new pharmacological strategy aimed at the selective removal of ONOO—, and can be an effective method in the treatment of joint diseases. Because cartilage receives nutrients through a diffusion-loading mechanism, and molecular hydrogen penetrates rapidly into tissues, it can be useful for the prevention of diseases of joints of degenerative origin. It reduces oxidative stress and slows down the reduction of matrix proteins and inhibition of proteinase degradation. Its effectiveness has been proven after injuries to the spinal cord, muscles and tendons, comorbid diseases such as hypertension, coronary heart disease, diabetes and metabolic syndrome. Key words. Molecular hydrogen, hydrogen water, hydrogen inhalations, joint diseases, consequences of musculoskeletal injuries, comorbid pathology.

Author Biographies

Vasyl Makolinets, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, Prof. in Traumatology and Orthopаedics

Kyrylo Makolinets, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

PhD in Traumatology and Orthopaedics

References

  1. Liu, W., Sun, X., & Ohta, S. (2015). Hydrogen element and hydrogen gas. Hydrogen Molecular Biology and Medicine, 1-23. https://doi.org/10.1007/978-94-017-9691-0_1
  2. Ehner Group Company. (n.d.). Hydrogen water: its secret and efficiency. http://h2server.ru/news/odorod-ee-sekret/. [in Russian]
  3. Ge, L., Yang, M., Yang, N., Yin, X., & Song, W. (2017). Molecular hydrogen: A preventive and therapeutic medical gas for various diseases. Oncotarget, 8(60), 102653-102673. https://doi.org/10.18632/oncotarget.21130
  4. Ichihara, M., Sobue, S., Ito, M., Ito, M., Hirayama, M., & Ohno, K. (2015). Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Medical gas research, 5, 12. https://doi.org/10.1186/s13618-015-0035-1
  5. Ishibashi, T. (2019). Therapeutic efficacy of molecular hydrogen: A new mechanistic insight. Current Pharmaceutical Design, 25(9), 946-955. https://doi.org/10.2174/1381612825666190506123038
  6. Ohta, S., Lee, G. H., Sun, X. J., Qin, B., & LeBaron, T. W. (2017). Definitions and Standards on Hydrogen Measurements and Certifications First proceedings from the International Hydrogen Standards Association (IHSA) announced at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China. https://jhypa.org/wp-content/uploads/2018/03/IHSA-Hydrogen-standards-2017.pdf.
  7. Ono, H., Nishijima, Y., Adachi, N., Sakamoto, M., Kudo, Y., Kaneko, K., Nakao, A., & Imaoka, T. (2012). A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Medical Gas Research, 2(1), 21. https://doi.org/10.1186/2045-9912-2-21
  8. Hanaoka, T., Kamimura, N., Yokota, T., Takai, S., & Ohta, S. (2011). Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research, 1(1), 18. https://doi.org/10.1186/2045-9912-1-18
  9. Ishibashi, T. (2013). Molecular hydrogen: New antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases. Current Pharmaceutical Design, 19(35), 6375-6381. https://doi.org/10.2174/13816128113199990507
  10. Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., … & Nagao, T. (2014). Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21(2), 468-473. https://doi.org/10.1016/j.intimp.2014.06.001
  11. Meng, J., Yu, P., & Jiang, H. (2016). Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress. American Journal of Translational Research, 8(10), 4472–4477
  12. Kasuyama, K., Tomofuji, T., Ekuni, D., Tamaki, N., Azuma, T., Irie, K., Endo, Y., & Morita, M. (2011). Hydrogen-rich water attenuates experimental periodontitis in a rat model. Journal of Clinical Periodontology, 38(12), 1085-1090. https://doi.org/10.1111/j.1600-051x.2011.01801.x
  13. Yoneda, T., Tomofuji, T., Kunitomo, M., Ekuni, D., Irie, K., Azuma, T., … & Morita, M. (2017). Preventive effects of drinking hydrogen-rich water on gingival oxidative stress and alveolar bone resorption in rats fed a high-fat diet. Nutrients, 9(1), 64. https://doi.org/10.3390/nu9010064
  14. Carnovali, M., Mariotti, M., & Banfi, G. (2021). Molecular hydrogen enhances osteogenesis in danio rerio embryos. Journal of Fish Biology. https://doi.org/10.1111/jfb.14670
  15. Li, D., Zhang, Q., Dong, X., Li, H., & Ma, X. (2013). Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. Journal of Bone and Mineral Metabolism, 32(5), 494-504. https://doi.org/10.1007/s00774-013-0530-1
  16. Guo, J., Li, L., Shi, Y., Wang, H., & Hou, S. (2013). Hydrogen water consumption prevents osteopenia in ovariectomized rats. British Journal of Pharmacology, 168(6), 1412-1420. https://doi.org/10.1111/bph.12036
  17. Sun, Y., Shuang, F., Chen, D. M., & Zhou, R. B. (2012). Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporosis International, 24(3), 969-978. https://doi.org/10.1007/s00198-012-2028-4
  18. Li, J., Ge, Z., Fan, L., & Wang, K. (2017). Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis. BMC Musculoskeletal Disorders, 18(1). https://doi.org/10.1186/s12891-017-1431-6
  19. Huang, S., Jiao, J., & Yan, H. (2015). Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model. Experimental and Therapeutic Medicine, 11(1), 177-182. https://doi.org/10.3892/etm.2015.2883
  20. Xiao, L., & Miwa, N. (2016). Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment. Human Cell, 30(2), 72-87. https://doi.org/10.1007/s13577-016-0150-x
  21. Huang, T., Wang, W., Tu, C., Yang, Z., Bramwell, D., & Sun, X. (2015). Hydrogen-rich saline attenuates ischemia–reperfusion injury in skeletal muscle. Journal of Surgical Research, 194(2), 471-480. https://doi.org/10.1016/j.jss.2014.12.016
  22. Meng, J., Yu, P., Tong, J., Sun, W., Jiang, H., Wang, Y., Xue, K., Xie, F., Qian, H., Liu, N., Zhao, J., & Bao, N. (2018). Hydrogen treatment reduces tendon adhesion and inflammatory response. Journal of Cellular Biochemistry, 120(2), 1610-1619. https://doi.org/10.1002/jcb.27441
  23. The effects of hydrogen-rich formulation for treatment of sport-related soft tissue injuries. https://clinicaltrials.gov/ct2/show/NCT01759498.
  24. Liu, F., Xu, S., Xiang, Z., Li, X., Li, J., Yuan, H., & Sun, X. (2014). Molecular hydrogen suppresses reactive Astrogliosis related to oxidative injury during spinal cord injury in rats. CNS Neuroscience & Therapeutics, 20(8), 778-786. https://doi.org/10.1111/cns.12258
  25. Chen, Y., Chen, H., Xie, K., Liu, L., Li, Y., Yu, Y., & Wang, G. (2015). H2Treatment attenuated pain behavior and Cytokine release through the HO-1/CO pathway in a rat model of neuropathic pain. Inflammation, 38(5), 1835-1846. https://doi.org/10.1007/s10753-015-0161-x
  26. Kawaguchi, M., Satoh, Y., Otsubo, Y., & Kazama, T. (2014). Molecular hydrogen attenuates neuropathic pain in mice. PLoS ONE, 9(6), e100352. https://doi.org/10.1371/journal.pone.0100352
  27. Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N., … & Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3), 137-143. https://doi.org/10.1016/j.nutres.2008.01.008
  28. Nakao, A., Toyoda, Y., Sharma, P., Evans, M., & Guthrie, N. (2010). Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome—An open label pilot study. Journal of Clinical Biochemistry and Nutrition, 46(2), 140-149. https://doi.org/10.3164/jcbn.09-100
  29. LeBaron, T., Singh, R., Fatima, G., Kartikey, K., Sharma, J. P., Ostojic, S., … & Slezak, J. (2020). The effects of 24-Week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: A randomized controlled trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 889-896. https://doi.org/10.2147/dmso.s240122
  30. Kamimura, N., Nishimaki, K., Ohsawa, I., & Ohta, S. (2011). Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in DB/DB mice. Obesity, 19(7), 1396-1403. https://doi.org/10.1038/oby.2011.6
  31. Yu, S., Zhao, C., Che, N., Jing, L., & Ge, R. (2017). Hydrogen-rich saline attenuates eosinophil activation in a Guinea pig model of allergic rhinitis via reducing oxidative stress. Journal of Inflammation, 14(1). https://doi.org/10.1186/s12950-016-0148-x

Downloads

How to Cite

Makolinets, V. ., Grashenkova, T. ., Moseichuk, V. ., Makolinets, K. ., & Moseichuk, V. . (2021). Molecular hydrogen as a possible therapeutic factor in complex rehabilitation therapy in patients with muscular skeletal disorders (literature review). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 92–97. https://doi.org/10.15674/0030-59872021192-97

Issue

No. 1 (2021)

Section

DIGESTS AND REVIEWS

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).