Relationships between humoral immunity indices and pathomorphological changes in the synovial membrane of the knee joint in patients with rheumatoid arthritis

Authors

  • Sergey Gerasimenko
  • Lesya Panchenko
  • Roman Nechyporenko
  • Olga Sokolovskaya

DOI:

https://doi.org/10.15674/0030-59872013472-76

Keywords:

rheumatoid arthritis, synovitis of knee joint, humoral immunity, synovium, synovial fluid, arthroscopic synovectomy

Abstract

The article assesses results of a study of the indices of humoral immunity in blood serum and synovial fluid and results of a pathomorphological analysis of the synovial membrane in patients with a proven diagnosis of rheumatoid arthritis (synovitis) of the knee joint, who underwent synovectomy with use of the arthroscopic technique. A relationship between the examined parameters was established and indications for knee joint synovectomy at early stages of the disease were substantiated.

References

  1. Features regeneration synovium and recurrence of synovitis after surgical synovectomy in patients with rheumatoid arthritis / A. B. Schechter, A. A. Krel, Z. P. Raschupkina et al.: sat scientific papers [«Exp. wedge. aspects of reparative processes and methods of stimulation»]. — M., 1977. — С. 119–124.
  2. Blahut J. Synovectomy of the knee joint / J. Blahut // Acta Chir. Orthop. Traumatol. Chech. — 2003. — Vol. 70 (6). — P. 371–376.
  3. Herzog O. A. The role of inflammatory cytokines in the pathogenesis of rheumatoid arthritis / O. A. Herzog, S. Sennikov // System cytokines: theoretical and clinical aspects / edited. V. A. Kozlov, S. V. Sennikova. — Novosibirsk: Nauka, 2004. — 324 р.
  4. Alekseevа A. A. Features of humoral immunity in patients with rheumatoid arthritis / A. A. Alekseevа // Perspectives medicine ta bіologії. — 2010. — Vol. 2, № 2. — P. 7–10.
  5. Piskunovа M. V. Immunological profile of patients with rheumatoid arthritis / M. V. Piskunovа // Fundamentalnie isledovanyya. — 2011. — № 1 — P. 148–156.
  6. Babko A. M. Orthodontic treatment of knee synovitis in patients with RA: dis. … candidate. med. sciences / A. M. Babko. — M., 2002. — 168 р.
  7. Fisher H. Limiting dilution analysis of proliferative T cell responses to mycobacterial 65-kDa heat-shock protein fails to show significant frequency differences between synovial fluid and peripheral blood of patients with rheumatoid arthritis / H. Fisher, C. Sharrock, M. Colston // Eur. J. Immunol. — 1991. — Vol. 21. — P. 2931–2941.
  8. Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity / R. L. De, A. P. Nicholas, T. Cantaert et al. // Arthritis Rheum. — 2005. — Vol. 52 (8). — Р. 2323–2330.
  9. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue / E. R. Vossenaar, T. J. Smeets, M. C. Kraan et al. // Arthritis Rheum. — 2004. — Vol. 50 (11). — Р. 3485–3494.
  10. Citrullination in extra-articular manifestations of rheumatoid arthritis / T. Bongartz, T. Cantaert, S. R. Atkins et al. // Rheumatol. — 2007. — Vol. 46 (1). — Р. 70–75.
  11. Manchini G. Immunological quantitation of antigenes by single radial diffusion / G. Manchini, A. Carbonare, J. Haremans // Immunochemistry. — 1965. — № 2. — P. 235–239.
  12. Haskova V. Novy spusob stanoveni circulyjcich immunokomplexes v lidskych serech / V. Haskova, J. Kaslik, A. Mate // Z Cas. Lek. Ceb. — 1977. — Vol. 14 (116). — C. 437–438.

How to Cite

Gerasimenko, S., Panchenko, L., Nechyporenko, R., & Sokolovskaya, O. (2014). Relationships between humoral immunity indices and pathomorphological changes in the synovial membrane of the knee joint in patients with rheumatoid arthritis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 72–76. https://doi.org/10.15674/0030-59872013472-76

Issue

Section

ORIGINAL ARTICLES