Morphological changes in bone tissue in conditions of a modelled traumatic injury of the tibial diaphysis in rats

Authors

DOI:

https://doi.org/10.15674/0030-59872013413-20

Keywords:

experiment, diaphysis injuries, structure of metaphysis

Abstract

Morphological and morphometric studies of distal tibial diaphyses in 21 rats after a modelled transcortical through perforated defect of the diaphysis and its fracture were carried out. Qualitative and quantitative data about characteristics of the compact and trabecular bone in the proximal and distal metaphyses were received. It was found out that both a low-intensity injury (a transcortical perforated defect) and a fracture affected the bone tissue state in the metaphyses. The most evident post-traumatic osteopoenic changes in the trabecular and compact bones were registered in the distal metaphysis after a diaphyseal fracture.

References

  1. Kröger H. Bone mineral density after the removal of intramedullary nails: a cross-sectional and longitudinal study / H. Kröger, J. Kettunen, M. Bowditch // Orthop. Sci. — 2002. — Vol. 7, № 3. — P. 325–330.
  2. Changes in bone mass and bone turnover following tibial shaft fracture / S. W. Vietch, S. C. Findlay, A. J. Hamer et al. // Osteoporosis Int. — 2006. — Vol. 17. — № 3. — Р. 364–372.
  3. Mineral density bone of skeleton to the great number fractures of bone lower extremities / A. A Sveshnikov., А. G. Karasev, L. A. Smotrova, E. N. Ovchinnikova // Henii orthopaedii. — 2006. — № 1. — P. 98–102.
  4. A meta-analysis of previous fracture and subsequent fracture risk / J. A. Kanis, O. Johnell, C. De Laet et al. // Bone. — 2004. — Vol. 35. — P. 375–382.
  5. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis / C. M. Klotzbuecher, P. D. Ross, P. B. Landsman et al. // J. Bone Miner Res — 2000. — Vol. 15. — P. 721–739.
  6. Osteopenia later of the trauma / А. А. Sveshnikov, L. А. Smotrova // Henii orthopaedii. — 2001. — № 1. — С. 99–104.
  7. European Convention for the Protection of Vertebrate Animals used for experimental and other scientific purposes. Strasbourg, 18 March 1986: official translation [electronic resource] / Parliament of Ukraine. - Off. website. - (International Council of Europe documents). - Access to document: http://zakon.rada.gov.ua/cgi-bin/laws/main.cginreg=994_137.
  8. Sarkisov D. S. Microscopic technics / D. S. Sarkisov, Yu. L. Perovа. — М.: Меdicine, 1996. — 542 с.
  9. Avtandilov G. G. Меdical morphometria / G. G. Avtandilov. — М.: Меdicine, 1990. — 381 p.
  10. Revell P. А. Patology of bone / P. А. Revell. — М.:Меdicine. 1993. — 367 p.
  11. Urinary osteocalcin is a useful marker for monitoring the effect of alendronate therapy / K. K. Ivaska, K. Pettersson, A. Nenonen et al. // Clin. Chem. — 2005. — Vol. 51. — P. 2362–2365.
  12. Development and evaluation of three immunofluorometric assays that measure different forms of osteocalcin in serum / S. M. Kakonen, J. Hellman, M. Karp et al. // Clin. Chem. — 2000. — Vol. 46. — P. 332–337.
  13. Deduch N. V. Patomorphology of bones tissue at osteoporos / N. V. Deduch // Osteoporos: epidemiologic, clinic, diagnostic, profilactic and triatment / N. А. Коrzh, V. V. Povoroznuk, N. V. Deduch at al. — H: Gold pages, 2002. — P. 52–54.
  14. Riggs B. L. Osteoporosis: еtiology, diagnosisand management / B. L. Riggs, L. G. Melton. — Lippincott: Raven Publisher, 1995. — 524 p.
  15. Sveshnikov А. А. Mechanism demineralization of bones tisue / А. А. Sveshnikov, L. A. Smotrova, Е. N. Ovchinnikov // Henii orthopaedii — 2005. — № 2. — P. 95–99.

How to Cite

Pobel, Y., Dedukh, N., & Malyshkina, S. (2014). Morphological changes in bone tissue in conditions of a modelled traumatic injury of the tibial diaphysis in rats. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (4), 13–20. https://doi.org/10.15674/0030-59872013413-20

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Section

ORIGINAL ARTICLES