Imperfect osteogenesis: pathogenesis, classification, clinical picture, treatment

Vladyslav Povorozniuk, Olena Grechanina, Nataliya Balatska, Volodymyr Vayda

Abstract


The authors present their review of special literature and results of treatment of patients with imperfect osteogenesis from different age groups. Emphasis is made on the pathogenesis of this disease; the above pathogenesis is caused by different variants of mutation of genes, which encode components of the chain of type I collagen. Kinds of imperfect osteogenesis, which are not related to pathology of the above collagen, are pointed out. The review describes in detail the clinical picture, includes a classification and characteristics of types of imperfect osteogenesis, contains diagnostic criteria and generalized results of treatment of this severe pathology. Results of the authors’ own studies are based on use of Pamidront for treating children. An algorithm for its prescription to patients with imperfect osteogenesis is described.

Keywords


osteogenesis imperfecta; classification; treatment bisphosphonates

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DOI: https://doi.org/10.15674/0030-598720094110-117

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