Experimental grounds for the use of composite materials based on chitosane and calcium phosphates for bone defect replacement

Authors

  • Sergey Danilchenko
  • Oksana Kalinkevich
  • Maksym Pogorelov
  • Anatoly Sklyar
  • Tatyana Kalinichenko
  • Olexiy Kalinkevich
  • Vadym Starikov
  • Valentina Bumeyster
  • Vitaly Sikora
  • Leonid Sukhodub

DOI:

https://doi.org/10.15674/0030-59872009166-72

Keywords:

bone defects, composites (chitosan and calcium phosphate)

Abstract

A number of chitosane/hydroxyl apatite composite materials were synthesized from aqueous solutions of a biopolymer and soluble salts-precursors. The composites were obtained in the dense and porous variants. The examinations conducted by the methods of X-ray diffraction analysis and infrared spectroscopy showed that apatite crystals in the composites had structural characteristics similar to those of biogenic apatite. Cylindrical rods, made of chitosane/hydroxyl apatite composite materials, were experimentally implanted into the tibial bone of linear laboratory rats in vivo. Histological and histomorphological studies for assessing osteoconductivity were performed 5, 10, 15 and 24 days after the implantation. The specimens were examined by the method of scanning electronic microscopy with X-ray microanalysis for comparing the elemental composition and morphological characteristics of the implant and bone during the integration. The results of the tests make it possible to conclude that chitosane/hydroxyl apatite composites are bioinert and biocompatible. The porous specimens also demonstrated satisfactory osteoconductive properties and were experimentally replaced in vivo by a newly formed bone tissue.

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How to Cite

Danilchenko, S., Kalinkevich, O., Pogorelov, M., Sklyar, A., Kalinichenko, T., Kalinkevich, O., Starikov, V., Bumeyster, V., Sikora, V., & Sukhodub, L. (2009). Experimental grounds for the use of composite materials based on chitosane and calcium phosphates for bone defect replacement. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 66–72. https://doi.org/10.15674/0030-59872009166-72

Issue

No. 1 (2009)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2014 Sergey Danilchenko, Oksana Kalinkevich, Maksym Pogorelov, Anatoly Sklyar, Tatyana Kalinichenko, Olexiy Kalinkevich, Vadym Starikov, Valentina Bumeyster, Vitaly Sikora, Leonid Sukhodub

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