Growth transformation factor (GTF) as a marker of a delayed consolidation of fractures

G. Zimmermann, P. Henle, M. Kusswette, A. Moghaddam, A. Wentzensen, W. Richter, S. Weiss

Abstract


The concentration of growth-transforming factor (GTF) β1 in blood serum was analysed in its dynamics in 103 patients with diaphyseal fractures of long bones depending upon the course of restorative osteogenesis, i.e. with the normal and delayed healing of the fracture. In order to exclude the factors, which could influence the restorative regeneration, the patients in both groups were distributed by their sex, age, type and localization of the fracture, technique of the osteosynthesis performed. Data were received about an early (4-6 weeks after the fracture) reduction in GTF β1 level in blood serum of the patients with a delayed consolidation. It was found out that GTF β1 was the main key molecule, which controlled the fracture healing, and could serve as a marker of a delayed consolidation.

Keywords


reparative osteogenesis; transforming growth factor (TGF- β)

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DOI: https://doi.org/10.15674/0030-59872009157-65

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