Growth transformation factor (GTF) as a marker of a delayed consolidation of fractures

Authors

  • G. Zimmermann
  • P. Henle
  • M. Kusswette
  • A. Moghaddam
  • A. Wentzensen
  • W. Richter
  • S. Weiss

DOI:

https://doi.org/10.15674/0030-59872009157-65

Keywords:

reparative osteogenesis, transforming growth factor (TGF- β)

Abstract

The concentration of growth-transforming factor (GTF) β1 in blood serum was analysed in its dynamics in 103 patients with diaphyseal fractures of long bones depending upon the course of restorative osteogenesis, i.e. with the normal and delayed healing of the fracture. In order to exclude the factors, which could influence the restorative regeneration, the patients in both groups were distributed by their sex, age, type and localization of the fracture, technique of the osteosynthesis performed. Data were received about an early (4-6 weeks after the fracture) reduction in GTF β1 level in blood serum of the patients with a delayed consolidation. It was found out that GTF β1 was the main key molecule, which controlled the fracture healing, and could serve as a marker of a delayed consolidation.

References

  1. Bab I. Regenerating bone marrow produces a potent growth-promoting activity to osteogenic cells / I. Bab, D. Gazit, A. Muhlrad, A. Shteyer // Endocrinology. —1988. — Vol. 123. — P. 345–352.
  2. Bostrom M.P. Expression of bone morphogenetic proteins in fracture healing / M.P. Bostrom // Clin. Orthop. — 1998. — Vol. 355. — P. 116–123.
  3. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing / M.P. Bostrom, J.M. Lane, W.S. Berberian [et al.] // J. Orthop. Res. — 1995. —Vol. 13. — P. 357–367.
  4. Bonewald L.F. Role of active and latent transforming growth factor beta in bone formation / L.F. Bonewald, S.L. Dallas // J. Cell Biochem. — 1994. — Vol. 55. — P. 350–357.
  5. The osteogenic response to distant skeletal injury / T.A. Einhorn, G. Simon, V.J. Devlin [et al.] // Bone Joint Surg. Am. — 1990. — Vol. 72. — P. 1374–1378.
  6. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair / T.A. Einhorn, R.J. Majeska, A. Mohaideen [et al.] // J. Bone Joint Surg. Am. — 2003. — Vol. 85(8). — P. 1425–1435.
  7. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions: a prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft / G.E. Friedlaender, C.R. Perry, J.D. Cole [et al.] // J. Bone Joint Surg. Am. — 2001. — Vol. 83-A. — P. 151–158.
  8. Regenerating marrow induces systemic increase in osteo- and chondrogenesis / D. Gazit, M. Karmish, L. Holzman, I. Bab // Endocrinology. — 1990. — Vol. 126. — P. 2607–2613.
  9. Recombinant TGF-beta1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice / D. Gazit, Y. Zilberman, G. Turgeman [et al.]// J. Cell Biochem. — 1999. — Vol. 73. — P. 379–389.
  10. Fracture healing as a postnatal developmental process: molecular, spatial, and temporal aspects of its regulation / L.C. Gerstenfeld, D.M. Cullinane, G.L. Barnes [et al.] // J. Cell Biochem. — 2003. — Vol. 88. — P. 873–884.
  11. Groeneveld E.H. Bone morphogenetic proteins in human bone regeneration / E.H. Groeneveld, E.H. Burger // Eur. J. Endocrinol. — 2000. — Vol. 142. — P. 9–21.
  12. Effects of bone morphogenetic protein and transforming growth factor-beta on biomechanical property for fracture healing in rabbit ulna / X.B. He, W.Z. Lu, K.L. Tang [et al.] // Zhongguo Xiufu Chongjian Waike Zazhi. — 2003. — Vol. 17. — P. 185–188.
  13. Ilizarov callus distraction produces systemic bone cell mitogens / O. Holbein, C. Neidlinger-Wilke, G. Suger [et al.] // J. Orthop. Res. — 1995. — Vol. 13. — P. 629–638.
  14. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation / Y. Ishidou, I. Kitajima, H. Obama [et al.] // J. Bone Miner. Res. — 1995. — Vol. 10. — P. 1651–1659.
  15. JoyceM.E. Transforming growth factor-beta in the regulation of fracture repair / M.E. Joyce, S. Jingushi, M.E. Bo-lander // Orthop. Clin. North Am. — 1990. — Vol. 21. — P. 199–209.
  16. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur / M.E. Joyce, A.B. Roberts, M.B. Sporn, M.E.Bolander // J. Cell Biol. — 1990. — Vol. 110. — P. 2195–2207.
  17. Mitogens are increased in the systemic circulation during bone callus healing / D. Kaspar, C. Neidlinger-Wilke, O. Holbein [et al.] // J. Orthop. Res. — 2003. — Vol. 21. — P. 320–325.
  18. Distraction bone healing versus osteotomy healing: a comparative biochemical analysis / J. Lammens, Z. Liu, J. Aerssens, J. Dequeker // J. Bone Miner. Res. — 1998. — Vol. 13. — P. 279–286.
  19. Manolagas S.C. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis / S.C. Manolagas, R.L. Jilka // N. Engl. J. Med. — 1995. — Vol. 332. — P. 305–311.
  20. Gene expression in older rats with delayed union of femoral fractures / R.A. Jr. Meyer, M.H. Meyer, M. Tenholder [et al.] // J. Bone Joint Surg. Am. — 2003. — Vol. 85-A. — P. 1243–1254.
  21. Miyazono K. Positive and negative regulation of TGF-beta signaling / K. Miyazono // J. Cell Sci. — 2000. — Vol. 113. — P. 1101–1109.
  22. Nunamaker D.M. Experimental models of fracture repair / D.M. Nunamaker // Clin. Orthop. Relat. Res. — 1998. — Vol. 355S. — P. 56–65.
  23. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats / T. Onishi, Y. Ishidou, T. Nagamine [et al.] // Bone. — 1998. — Vol. 22. — P. 605–612.
  24. Park S.H. Interaction between active motion and exogenous transforming growth factor Beta during tibial fracture repair / S.H. Park, K.M. O’Connor, H. McKellop // J. Orthop. Trauma. — 2003. — Vol. 17. — P. 2–10.
  25. Synergistic effect of IGF-I and TGF-beta1 on fracture healing in rats: single versus combined application of IGF-I and TGFbeta1 / G. Schmidmaier, B. Wildemann, T. Gabelein [et al.] // Acta Orthop. Scand. — 2003. — Vol. 74. — P. 604–610.
  26. Improvement of fracture healing by systemic administration of growth hormone and local application of insulinlike growth factor-1 and transforming growth factor-beta1 / G. Schmidmaier, B. Wildemann, J. Heeger [et al.] // Bone. — 2002. — Vol. 31. — P. 165–172.
  27. Expression of BMP-2 and TGF-beta 1 mRNA during healing of the rabbit mandible / X. Si, Y. Jin, L. Yang [et al.] // Eur. J. Oral. Sci. — 1997. — Vol. 105. — P. 325–330.
  28. The angiogenic response to skeletal injury is preserved in the elderly / T.J. Street, J.H. Wang, Q.D. Wu, E. Al // J. Orthop. Res. — 2001. — Vol. 19. — P. 1057–1066.
  29. The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect / L. Tieline, P. Puolakkainen, T. Pohjonen [et al.] // Biomaterials. — 2002. — Vol. 23. — P. 3817–3823.
  30. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair / A. Vortkamp, S. Pathi, G.M. Peretti [et al.] // Mech. Dev. — 1998. — Vol. 71. — P. 65–76.
  31. Systemic regulation of distraction osteogenesis: a cascade of biochemical factors / S. Weiss, R. Baumgart, M. Jochum [et al.] // J. Bone Miner. Res. — 2002. — Vol. 17. — P. 1280–1289.
  32. Colocalization of noggin and bone morphogenetic protein-4 during fracture healing / Y. Yoshimura, S. Nomura, S. Kawasaki [et al.] // J. Bone Miner. Res. — 2001. — Vol. 16. — P. 876–884.
  33. Early period of fracture healing in ovariectomized rats / S.W. Xu, R. Yu, G.F. Zhao, J.W. Wang // Chin. J. Traumatol. — 2003. — Vol. 6. — P. 160–166.

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How to Cite

Zimmermann, G., Henle, P., Kusswette, M., Moghaddam, A., Wentzensen, A., Richter, W., & Weiss, S. (2009). Growth transformation factor (GTF) as a marker of a delayed consolidation of fractures. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 57–65. https://doi.org/10.15674/0030-59872009157-65

Issue

No. 1 (2009)

Section

ORIGINAL ARTICLES

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Copyright (c) 2014 G. Zimmermann, P. Henle, M. Kusswette, A. Moghaddam, A. Wentzensen, W. Richter, S. Weiss

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