Clinical-morphological peculiarities of bone lesions in patients with imperfect osteogenesis

Authors

  • Valeriy Hryhorovskyi
  • Yuriy Guk
  • Sadruddin Magomedov
  • Viktor Stelmakh
  • Andrey Zima

DOI:

https://doi.org/10.15674/0030-59872010146-54

Keywords:

imperfect osteogenesis, bone biopsy, pathomorphology study, clinical characteristics, laboratory parameters, the frequency of pathological changes, correlation parameters

Abstract

According to the results of a clinical-morphological analysis, histological and semiquantitative morphometric investigations of 20 long-bone biopsies from patients with different types of imperfect osteogenesis (IO), pathomorphological peculiarities of the bone tissue, rate of pathological changes and correlations between different clinical- clinical-laboratory and quantified morphological indices in this disease were studied. Variations were registered in the occurrence of such bone pathology signs as development of the compact substance spongiosis, prevalence of some type of the bone tissue, i.e. compact or reticulofibrous, prevalence of signs of the phase of osteoresorption or osteogenesis of reconstruction cycles, presence of bone regenerates. On the basis of correlations in pairs of gradation indices, a reliable negative relation with the tightness parameter, which approached its mean value, was established between peculiarities in drug therapy of IO patients and prevalent signs of bone tissue reconstruction phases.

References

  1. Волков М. В. Несовершенное костеобразование [Текст] / М. В. Волков, Н. Н. Нефедьева. — М.: Медицина, 1974. — 119 с.
  2. Дифференциальная диагностика врожденных форм несовершенного остеогенеза у детей [Текст] / О. К. Головко, Е. М. Левицкая, И. А. Малеева и др. // Проблеми остеології. — 2001. — № 3. — С. 52–54.
  3. Камышников В. С. Справочник по клинико-биохимическим исследованиям и лабораторной диагностике [Текст] / В. С. Камышников. — М.: Медпрессинформ, 2004. — 911 с.
  4. Осипенкова-Вичтомова Т. К. Костная ткань при несовершенном остеогенезе (светооптическое и электронно-микроскопическое исследование) [Текст] / Т. К. Осипенкова-Вичтомова // Арх. пат. — 2006. — № 3. — С. 20–25.
  5. Ревелл П. А. Несовершенное костеобразование [Текст] / П. А. Ревелл // Патология кости. — М.: Медицина, 1993. — С. 70–76.
  6. Bullough P. G. Nonneoplastic Diseases of Bones [Text] / P. G. Bullough // Diagnostic Surgical Pathology [ed. S. S. Sternberg]. — 3-rd Ed. — Philadelphia: Lippincott Williams & Wilkins, 1999. — V. 1. — P. 243–261.
  7. A morphometric analysis of osteoid collagen fibril diameter in osteogenesis imperfecta [Text] / J. P. Cassella, P. Barber, A. C. Catterall, Ali S. Yousufi // Bone. — 1994. — V. 15, N 3. — P. 329–334.
  8. Falvo K. A. Osteogenesis imperfecta: a histometric analysis [Text] / K. A. Falvo, P. G. Bullough // J. Bone and Joint Surg. — 1973. — V. 55-A, N 2. — P. 275–286.
  9. The volumetric bone density and cortical thickness in adult patients affected by osteogenesis imperfecta [Text] / D. Gatti, F. Colapietro, E. Fracassi et al. // J. Clin. Densitometry. — 2003. — V. 6, N 2. — P. 173–177.
  10. Malluche H. H. Osteogenesis imperfecta [Text] / H. H. Malluche, M.-C. Faugere // Atlas of Mineralized Bone Histology. — Basel: Karger, 1986. — P. 109–111.
  11. Martin E. Osteogenesis imperfecta: epidemiology and pathophysiology [Text] / E. Martin, J.R. Shapiro // Curr. Osteoporos. Rep. — 2007. — V. 5, N 3. — P. 91–97.
  12. Static and dynamic bone histomorphometry in children with osteogenesis imperfecta [Text] / F. Rauch, R. Travers, A.M. Parfitt, F.H. Glorieux // Bone. — 2000. — V. 26, N 6. — P. 581–589.
  13. The effects of intravenous pamidronate on bone mineral density, bone histomorphometry, and parameters of bone turnover in adults wiyh type IA osteogenesis imperfecta [Text] / J. R. Shapiro, E. F. McCarthy, K. Rossiter et al. // Calcif. Tissue Int. — 2003. — V. 72, N 2. — P. 103–112.
  14. Sillence D. O. Genetic heterogeneity in osteogenesis imperfecta [Text] / D. O. Sillence, A. Senn, D. M. Danks // J. Med. Genetics. — 1979. — V. 16, N 2. — P. 101–116.
  15. Osteogenesis imperfecta: comparison of molecular defects with bone histologycal changes [Text] / R. Sztrolovics, F. H. Glorieux, R. Travers et al. // Bone. — 1994. — V. 15, N 3. — P. 321–328.
  16. Osteogenesis imperfecta and its molecular diagnosis by determination of mutations of type I collagen genes [Text] / E. Tedeschi, F. Antoniazzi, G. Ventun et al. // Pediatr. Endocrinol. Rev. — 2006. — V. 4, N 1. — P. 40–46.

Downloads

How to Cite

Hryhorovskyi, V., Guk, Y., Magomedov, S., Stelmakh, V., & Zima, A. (2010). Clinical-morphological peculiarities of bone lesions in patients with imperfect osteogenesis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 46–54. https://doi.org/10.15674/0030-59872010146-54

Issue

No. 1 (2010)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2014 Valeriy Hryhorovsky, Yuriy Guk, Sadruddin Magomedov, Viktor Stelmakh, Andrey Zima

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).