DOI: https://doi.org/10.15674/0030-59872018244-48
Open Access Open Access  Restricted Access Subscription Access

Punction biopsy for diagnostics of neoplasms in thoracic and lumbar spine

Andrey Popov

Abstract


The final stage of spine neoplasm diagnostics is histological examination. In order to obtain the tissue from neoplasm punction biopsy is used.

Objective: to assess the efficacy of punctional biopsy with further pathohistological examination in patients with neoplasm in thoracic and lumbar spine.

Methods: we analyzed 259 case histories of patients with pathological spine changes.

Results: punction biopsy was made in 238 patients (89 %). In 30 (11 %) patients it was no effective because of the large amount of obtained material, in 27 (10 %) pathohistological diagnosis was not established. Pepeated biopsy was made in these cases. As a result at primary and secondary biopsies the diagnosis was confirmed in 95.5 %.

Conclusions: punctional biopsy with pathohystological examination is integral part of diagnostic process at spine neoplasm. It allows to obtain enough material for studying (inspite of the dense of tissues) to decrease the risks of contamination of surrounded tissues. Such minimalinvasive method gives possibility to use it in patients with comorbidities. Most of primary spine cancer is represented by myeloma and malignant lymphoma. Episodic were cases of hondrosarcoma, osteosarcoma and fibrosarcoma, when the lesion was spread on one or two vertebrae. Most frequent non malignant lesions were haemangioma and eosino­philic granuloma. Metastatic disease were revealed in 74 (28 %) of patients and often appeared in cases of low grade cancer and adenocarcinoma.


Keywords


diagnostics, punctional biopsy; pathological spine changes

References


Korzh, N. & Popov, A. (2010). Basic principles of diagnosis and treatment of spinal tumors. Health Ukraine: medical newspaper, 3,41–42. (in Russian)

Asdourian, P. L. (1997). Metastatic disease of the spine. The textbook of spinal surgery (2nd ed.) (pp. 2007–2048). In K. H. Bridwell, R. L. DeWald (Ed.). Philadelphia.

Rimondi, E., Rossi, G., Bartalena, T., Ciminari, R., Alberghini, M., Ruggieri, P., … Mercuri, M. (2011). Percutaneous CT-guided biopsy of the musculoskeletal system: Results of 2027 cases. European Journal of Radiology, 77(1), 34-42. doi:10.1016/j.ejrad.2010.06.055

Gelb, D. E. (1997). Bening tumors of the spine. The textbook of spinal surgery (2nd ed.) (pp. 1959–1978). In K. H. Bridwell, R. L. DeWald (Ed.). Philadelphia.

Komarov, I. & Komov, D. (2002). Metastases of malignant tumors of unknown primary origin. Moscow: «Тriada-Х». (in Russian)

Pavlidis, N., & Pentheroudakis, G. (2012). Cancer of unknown primary site. Lancet, 379(9824), 1428–1435. doi:10.1016/S0140-6736(11)61178-1

Krulik, M. (1996). Metastatic cancer of unknown primary site. Presse médicale, 25(35), l754–1762.

Rimondi, E., Staals, E. L., Errani, C., Bianchi, G., Casadei, R., Alberghini, M., … Mercuri, M. (2008). Percutaneous CT-guided biopsy of the spine: results of 430 biopsies. European Spine Journal, 17(7), 975-981. doi:10.1007/s00586-008-0678-x

Garg, V., Kosmas, C., Josan, E. S., Partovi, S., Bhojwani, N., Fergus, N., … Robbin, M. R. (2016). Computed tomography–guided percutaneous biopsy for vertebral neoplasms: a department's experience and hybrid biopsy technique to improve yield. Neurosurgical Focus, 41(2), E17. doi:10.3171/2016.4.focus1614

Radchenko, V., Kutcenko, V., & Popov, А. (2016). Puncture biopsy in the diagnosis of primary lesions of the spine. Paper presented at the XVII Congress of orthopaedists and traumatologists Ukrainian (4 octouber 2016 р.) (pp. 293-294). Kiev. (in Ukrainian)

Sarkisov, D., & Perov, U. (1996). Microscopic technique. Мoscow: Medicine. (in Russian)

Vyrva, O., & Golovina, O. (2010). A classification of bone tumors. Orthopaedics, traumatology and prosthetics, 4, 88-91. doi:10.15674/0030-59872010488-91. (in Russian)

Neishtadt, E. & Markochev, A. (2007). Tumors and opuholepodobns(e) bone disease. St. Petersburg: Pholiant. (in Russian)

WHO Classification of tumours of soft tissue and bone (4th ed.). (2013). In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, F. Mertens. WHO, IARC.




Copyright (c) 2018 Andrey Popov

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.