Musculus multifidus makes provisions to posterolateral spine fusion after transpedicular fixation of lumbar spine

Authors

DOI:

https://doi.org/10.15674/0030-59872018213-21

Keywords:

spine fusion, vertebral fusion, m. multifidus, histology, vertebrae stabilization, in vivo study

Abstract

Disturbances of structure and function of paravertebral muscles are one of the risk factors of lumbar spine degenerative diseases. It is proved that muscles play an important role in spine fusion and in other bones fusion.

Objective: to analyze the relationship between the results of the posterolateral lumbar fusion after stabilization of LIV–LV vertebrae with the use of transpedicular screws and structural features of m. multifidus caused by different levels of physical activity.

Methods: 20 laboratory rats were divided in four groups, each of five animals: І — have swum before and after surgery; ІІ — have swum before surgery only; IІІ — have swum after surgery only; ІV — have not swum. All animals underwent posterolateral spinal fusion, transpedicular construction was mounted at LIV–LV level. X -ray examination was performed directly after surgical procedure, and 3 months later. Histologic study was performed for evaluating of m. multifidus and spine fusion area.

Results: using X-ray examination the signs of formed posterior spine fusion were observed 3 months after operation in 80 % animals of I group, in 60 % of II, in 40 % of III, in 20 % of IV. Histologically it was established that the degree of muscles changes directly correlates with the quality of spine fusion. Minimal signs of muscle fibers destructive changes, as well as maximum observations of formed spine fusion, were registered in the I group under increased physical activity regimen, while most evident destructive changes and the worst results — in IV group with low physical activities. We have established weak but statistically significant correlations between increased physical activity and reduction of the content of adipose (р = 0.010512) and fibrous (р = 0.019142) tissue in the muscles of operated rats.

Conclusion: physical activity has a positive influence upon functional and adaptive muscle capacity and forming of posterior spine fusion.

Author Biographies

Volodymyr Radchenko, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

 MD, Prof. in Traumatology and Orthopaedics 

 

Artem Skidanov, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

PhD

 

Nataliya Ashukina

PhD in Biol. Sci. 

 

 

Zinaida Danyshchuk, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

 

 

 

Dmytro Morozenko

 

 

Nikita Skidanov, Kharkiv National Medical University. Ukraine 

 

 

 

References

  1. Skidanov, A., Avrunin, A., Tymkovych, M., Zmiyenko, Y., Levitskaya, L., Mischenko, L., & Radchenko, V. (2015). Assessment of paravertebral soft tissues using computed tomography. Orthopaedics, traumatology and prosthetics, 3, 61-64. doi: https://doi.org/10.15674/0030-59872015361-64
  2. Danyshchuk, Z. N., Skidanov, A. G., & Batura, I. A. (2013). Morphology of paravertebral muscles in patients with generative diseases of lumbar spine. Tavricheskii mediko-biologicheskii vestnik, 16(16), 37–41.
  3. Crossman, K., Mahon, M., Watson, P. J., Oldham, J. A., & Cooper, R. G. (2004). Chronic low back pain-associated paraspinal muscle dysfunction is not the result of a constitutionally determined “Adverse” Fiber-type Composition. Spine, 29(6), 628-634. doi: https://doi.org/10.1097/01.brs.0000115133.97216.ec
  4. Hultman, G., Nordin, M., Saraste, H., & Ohlsen, H. (1993). Body composition, endurance, strength, cross-sectional area, and density of mm erector spinae in men with and without low back pain. Journal of Spinal Disorders & Techniques, 6(2), 114-123. doi: https://doi.org/10.1097/00024720-199304000-00004
  5. Radchenko, V., Skidanov, A., Zmiyenko, Y., Levitskaya, L., & Mischenko, L. (2014). Assessment of the state of paravertebral muscles of the lumbar spine with help of computed tomography (Review of literature). Orthopaedics, traumatology and prosthetics, 4, 128-133. doi: https://doi.org/10.15674/0030-598720134128-133
  6. Duplij, D. R., Skidanov, A. G.,. Kotulskyj, I. V, & Radchenko, V. A. (2015). Comparative estimation of electromyography and imaging study indicators of sarcopenic-related alterations of paravertebral muscles. Pain. Joints. Spine, 2(18), 87.
  7. Skidanov, A., Dupliy, D., Kotulskiy, I., Barkov, O., Kis, A., Piontkovsky, V., & Radchenko, V. (2015). Functional state of back muscles in patients with degenerative spine disorders. Orthopaedics, traumatology and prosthetics, 4, 59-68. doi: https://doi.org/10.15674/0030-59872015459-68
  8. Radchenko, V., Dedukh, N., Ashukina, N., & Skidanov, A. (2014). Structural features of paravertebral muscles in normal condition and degenerative diseases of the lumbar spine (literature review). Orthopaedics, traumatology and prosthetics, 4, 122-127. doi: https://doi.org/10.15674/0030-598720144122-127
  9. Rissanen A. (2004). Back muscles and intensive rehabilitation on patients with chronic low back pain. Effects on back muscle structure and function and patient disability: diss. Jyvaskyla: University of Jyvaskyla.
  10. Crawford, R. J., Volken, T., Valentin, S., Melloh, M., & Elliott, J. M. (2016). Rate of lumbar paravertebral muscle fat infiltration versus spinal degeneration in asymptomatic populations: an age-aggregated cross-sectional simulation study. Scoliosis and Spinal Disorders, 11(1). doi: https://doi.org/10.1186/s13013-016-0080-0
  11. Khvisyuk, N. I., Radchenko, V. A., & Korzh, N. A. (2001). Stabilization in injuries of thoracic and lumbar spine The Damages of the spine and spinal cord. Kyiv: Kniga plus.
  12. Radchenko, V. A., & Korzh, N. A. (2004). Workshop on the stabilization of thoracic and lumbar spin. Kharkov: Prapor.
  13. Radchenko, V. A., & Korzh, N. A. (2011). Orthopedist’ Handbook. Kyiv: ООО «Doctor media».
  14. Kotani, Y., Abumi, K., Sudo, H., Nagahama, K., Iwata, A., Ito, M., & Minami, A. (2011). Effect of minimally invasive lumbar posterolateral fusion using percutaneous pedicle screw on paravertebral muscle change and postoperative residual low back pain. The Spine Journal, 11(10), S103-S104. doi: https://doi.org/10.1016/j.spinee.2011.08.257
  15. Boden, S. D. (2000). Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Engineering, 6(4), 383-399. doi: https://doi.org/10.1089/107632700418092
  16. Boden, S. D., & Schimandle, J. H. (1996). Biology of lumbar spine fusion and bone graft materials International Society for Study of the Lumbar Spine Editorial Committee (pp. 1284–1306). Philadelphia, PA: Saunders.
  17. Theiss, S. M., Boden, S. D., Hair, G., Titus, L., Morone, M. A., & Ugbo, J. (2000). The effect of nicotine on gene expression during spine fusion. Spine, 25(20), 2588–2594.
  18. Bawa, M., Schimizzi, A. L., Leek, B., Bono, C. M., Massie, J. B., Macias, B., … Kim, C. W. (2006). Paraspinal muscle vasculature contributes to posterolateral spinal fusion. Spine, 31(8), 891-896. doi: https://doi.org/10.1097/01.brs.0000209301.15262.56
  19. Grauer, J. N., Patel, T. C., Erulkar, J. S., Troiano, N. W., Panjabi, M. M., & Friedlaender, G. E. (2001). Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion. Spine, 26(2), 127-133. doi: https://doi.org/10.1097/00007632-200101150-00004
  20. Skidanov, A., Ashukina, N., Danishchuk, Z., Batura, I., & Radchenko, V. (2015). Structural features multifidus muscle of rats after transpedicular fixation of vertebrae by various conditions of physical activity. Orthopaedics, traumatology and prosthetics, 2, 85-91. doi: https://doi.org/10.15674/0030-59872015285-91
  21. Cierny, G., Byrd, H. S., & Jones, R. E. (1983). Primary versus Delayed Soft Tissue Coverage for Severe Open Tibial Fractures. Clinical Orthopaedics and Related Research, &NA;(178),54-63. doi: https://doi.org/10.1097/00003086-198309000-00008
  22. Connolly, J. F., Guse, R., Tiedeman, J., & Dehne, R. (1991). Autologous Marrow Injection as a Substitute for Operative Grafting of Tibial Nonunions. Clinical Orthopaedics and Related Research, &NA;(266), 259-270. doi: https://doi.org/10.1097/00003086-199105000-00038
  23. Gejo, R., Kawaguchi, Y., Kondoh, T., Tabuchi, E., Matsui, H., Torii, K., … Kimura, T. (2000). Magnetic resonance imaging and histologic evidence of postoperative back muscle injury in rats. Spine, 25(8), 941-946. doi: https://doi.org/10.1097/00007632-200004150-00008
  24. Hu, Y., Leung, H. B., Lu, W. W., & Luk, K. D. (2008). Histologic and Electrophysiological changes of the paraspinal muscle after spinal fusion. Spine, 33(13), 1418-1422. doi: https://doi.org/10.1097/brs.0b013e3181753bea
  25. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of Europe. Strasbourg, 18 Mar 1986.
  26. Radchenko,V., Skidanov, А., Іvanov, G., & Steshenko V. (2014). Interbody fusion method in experimental animals. Ukraine. Pat. 94502 UA.
  27. Radchenko, V., Skidanov, A., Ivanov, G., Ashukina, N., & Levytskyi, P. (2014). Modeling of fixation with using of transpedicular constructs in the lumbar spine of the rats. Orthopaedics, traumatology and prosthetics, 3, 86-89. doi: https://doi.org/10.15674/0030-59872014386-89
  28. Mannion, A. F., Dumas, G. A., Cooper, R. G., Espinosa, F. J., Faris, M. W., & Stevenson, J. M. (1997). Muscle fibre size and type distribution in thoracic and lumbar regions of erector spinae in healthy subjects without low back pain: normal values and sex differences. Journal of Anatomy, 190(4), 505-513. doi: https://doi.org/10.1046/j.1469-7580.1997.19040505.x
  29. Matsumoto, T., Toyoda, H., Dohzono, S., Yasuda, H., Wakitani, S., Nakamura, H., & Takaoka, K. (2011). Efficacy of interspinous process lumbar fusion with recombinant human bone morphogenetic protein-2 delivered with a synthetic polymer and β-tricalcium phosphate in a rabbit model. European Spine Journal, 21(7), 1338-1345. doi: https://doi.org/10.1007/s00586-011-2130-x
  30. Steinmann, J. C., & Herkowitz, H. N. (199). Pseudarthrosis of the spine. Clinical Orthopaedics, 284, 80–90.
  31. Kim, K., Lee, S., Lee, Y., Bae, S., & Suk, K. (2006). Clinical outcomes of 3 fusion methods through the posterior approach in the lumbar spine. Spine, 31(12), 1351-1357. doi: https://doi.org/10.1097/01.brs.0000218635.14571.55
  32. Walsh, W. R., Vizesi, F., Cornwall, G. B., Bell, D., Oliver, R., & Yu, Y. (2009). Posterolateral spinal fusion in a rabbit model using a collagen–mineral composite bone graft substitute. European Spine Journal, 18(11), 1610-1620. doi: https://doi.org/10.1007/s00586-009-1034-5
  33. Choi, Y., Kim, D., Park, J., Johnstone, B., & Yoo, J. (2015). Effectiveness of posterolateral lumbar fusion varies with the physical properties of demineralized bone matrix strip. Asian Spine Journal, 9(3), 433. doi: https://doi.org/10.4184/asj.2015.9.3.433
  34. Teichtahl, A. J., Urquhart, D. M., Wang, Y., Wluka, A. E., O’Sullivan, R., Jones, G., & Cicuttini, F. M. (2015). Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability. Arthritis Research & Therapy, 17(1). doi: https://doi.org/10.1186/s13075-015-0629-y
  35. Hides, J. A., Stokes, M. J., Saide, M., Jull, G. A., & Cooper, D. H. (1994). Evidence of lumbar multifidus muscle wasting ipsilateral to symptoms in patients with acute/subacute low back pain. Spine, 19(Supplement), 165-172. doi: https://doi.org/10.1097/00007632-199401001-00009
  36. Kalichman L., Hodges, P., Li, L., Guermazi, A., & Hunter, D. J. (2010). Changes in paraspinal muscles and their association with low back pain and spinal degeneration: CT study. European Spine Journal, 19(7):1136–1144. doi: https://doi.org/10.1007/s00586-009-1257-5

Downloads

How to Cite

Radchenko, V., Skidanov, A., Ashukina, N., Danyshchuk, Z., Nessonova, M., Morozenko, D., & Skidanov, N. (2023). Musculus multifidus makes provisions to posterolateral spine fusion after transpedicular fixation of lumbar spine. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (2), 13–21. https://doi.org/10.15674/0030-59872018213-21

Issue

No. 2 (2018)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2018 Volodymyr Radchenko, Artem Skidanov, Nataliya Ashukina, Zinaida Danyshchuk, Marina Nessonova, Dmytro Morozenko, Nikita Skidanov

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).