Hyaluronic acid drugs in the treatment of joint pathology (literature review)

Authors

DOI:

https://doi.org/10.15674/0030-598720181117-124

Keywords:

arthritis, treatment, injection therapy, hyaluronic acid, mechanism of action, Sertobec

Abstract

On the base of literature review the possibility of hyaluronic acid application in the treatment of patients with arthritis and diseases of joint adjacent tissues was assessed. hyaluronic acid is important component of joint tissues, provides its normal function. At arthritis changes appear normal concentration of hyaluronic acid and its molecular weight decreases, it can lead to the violation of structural and biomechanical joint properties. Increasing of the level of hyaluronic acid in the joint due to intraarticular injections can help to restore viscosity properties of synovial fluid, provides chondroprotective, anti-inflammatory and pain relief actions. The most studied mechanism of hyaluronic acid is its ability to connect with CD44, due to this interleikin 1β, 6 and 8, prostaglandin E2, metalloproteinase expression are suppressed. Hyaluronic acid promotes the synthesis of chondral matrix (proteoglycans and collagen), decreases the frequency of chondrocytes apoptosis. Ability of hyaluronic acid to activate the migration of slightly differentiated cells and proliferation of fibroblasts could use it for the treatment of joint pathology. The results of the most of the studies, systematic reviews and meta-analysis tell about positive clinical appliance of hyaluronic acid drugs in the treatment of arthritis of the I–III stages. But the efficacy of such medicines depends on its origin, molecular weight, elasticity and duration of treatment. New direction of intraarticular therapy is combination of hyaluronic acid with chondroitin sulfate, which provide symptomatic and chondromodification action. For the discovery of the full mechanism of influence further studies must be performed. Drugs Sertobec can be medical drugs for the treatment of patients with arthritis and diseases of joint adjacent tissues.

Author Biographies

Oleg Vyrva, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

MD, Prof. in Orthopaedics and Traumatology 

 

Nataliya Ashukina, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv

PhD in Biol. Sci.  

 

References

  1. Zhang, Y., & Jordan, J. M. (2010). Epidemiology of Osteoarthritis. Clinics in Geriatric Medicine, 26(3), 355-369. doi:10.1016/j.cger.2010.03.001
  2. Kovalenko, V. N., Bortkevych, O. P., & Boichuk, N. S. (2015). Primeneniye preparatov gialuronovoy kisloty dlya lecheniya pri osteoartroze [The use of hyaluronic acid for the treatment of osteoarthritis]. Ukrayins’kyy revmatolohichnyy zhurnal, 1 (59), 51–54. (in Russian)
  3. Lespasio, M. J., Piuzzi, N. S., Husni, M. E., Muschler, G. F., Guarino, A., & Mont, M. A. (2017). Knee Osteoarthritis: A Primer. The Permanente Journal, 21, 16–183. http://doi.org/10.7812/TPP/16-183
  4. Lespasio, M. J., Sultan, A. A., Piuzzi, N. S., Khlopas, A., Husni, M. E., Muschler, G. F., & Mont, M. A. (2018). Hip Osteoarthritis: A Primer. The Permanente Journal,22, 17–084. http://doi.org/10.7812/TPP/17-084
  5. Roos, E. M., & Arden, N. K. (2015). Strategies for the prevention of knee osteoarthritis. Nature Reviews Rheumatology, 12(2), 92-101. doi:10.1038/nrrheum.2015.135
  6. Weinstein, A. M., Rome, B. N., Reichmann, W. M., Collins, J. E., Burbine, S. A., Thornhill, T. S., … Losina, E. (2013). Estimating the Burden of Total Knee Replacement in the United States. The Journal of Bone and Joint Surgery. American Volume, 95(5), 385–392. http://doi.org/10.2106/JBJS.L.00206
  7. Kiadaliri, A. A., Lohmander, L. S., Moradi-Lakeh, M., Petersson, I. F., & Englund, M. (2017). High and rising burden of hip and knee osteoarthritis in the Nordic region, 1990–2015. Acta Orthopaedica, 1-7. doi:10.1080/17453674.2017.1404791
  8. Korzh, M., Gaiko, G., Filipenko, V., Gerasimenko, S., & Tankut, V. (2014). Status and problematic issues of joint replacement in Ukraine (an enforcement of the XVI Congress of orthopaedics and traumatologists of Ukraine). Orthopaedics, Traumatology and Prosthetics, 1, 81-86. doi:http://dx.doi.org/10.15674/0030-59872014181-86 (in Ukrainian)
  9. Pavlova, V. N., Pavlov, G. G., & Shostak, N. A. (Eds.) (2011). Sustav: morfologiya, klinika, diagnostika, lecheniye [Joint: morphology, clinic, diagnosis, treatment]. Moscow: ООО “Izd-vo “Meditsinskoye «Meditsinskoye informatsionnoye agentstvo». (in Russian)
  10. Korzh, N. A., Dedukh, N. V., & Zupanats, I. A. (Eds.) (2007). Osteoartroz: konservativnaya terapiya [Osteoarthritis: conservative therapy]. Kharkov: Zolotie stranitsi. (in Russian)
  11. Vyrva, O. E. (2000). Artificial synovial fluid in the treatment of pathology of the knee joint. Orthopaedics, Traumatology and Prosthetics, 2, 146–150. (in Russian)
  12. Fedorishchev, I. A. (2011). Hyaluronic acid. Book 1. TulGU. (in Russian)
  13. Sigaeva, N. N., Kolesov, S. V., Nazarov, P. V., & Vildaniva, R. R. (2012). Khimicheskaya modifikatsiya gialuronovoy kisloty i yeye primeneniye v meditsine [Chemical modification of hyaluronic acid and its use in medicine]. Vestnik Bashkirskogo universiteta, 17 (3), 1220-1241. (in Russian)
  14. Goldberg, V., & Buckwalter, J. (2005). Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis and Cartilage, 13(3), 216-224. doi:10.1016/j.joca.2004.11.010
  15. Goldberg, V. (2010). Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis. Journal of Pain Research, 51. doi:10.2147/jpr.s4733
  16. Henrotin, Y., Hauzeur, J., Bruel, P., & Appelboom, T. (2012). Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters. BMC Research Notes, 5(1), 407. doi:10.1186/1756-0500-5-407
  17. Ando, A., Hagiwara, Y., Chimoto, E., Hatori, K., Onoda, Y., & Itoi, E. (2008). Intra-articular Injection of Hyaluronan Diminishes Loss of Chondrocytes in a Rat Immobilized-Knee Model. The Tohoku Journal of Experimental Medicine, 215(4), 321-331. doi:10.1620/tjem.215.321
  18. Brun, P., Zavan, B., Vindigni, V., Schiavinato, A., Pozzuoli, A., Iacobellis, C., & Abatangelo, G. (2012). In vitroresponse of osteoarthritic chondrocytes and fibroblast-like synoviocytes to a 500-730 kDa hyaluronan amide derivative. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100B(8), 2073-2081. doi:10.1002/jbm.b.32771
  19. Julovi, S. M., Yasuda, T., Shimizu, M., Hiramitsu, T., & Nakamura, T. (2004). Inhibition of interleukin-1?-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis & Rheumatism, 50(2), 516-525. doi:10.1002/art.20004
  20. Mongkhon, J., Thach, M., Shi, Q., Fernandes, J. C., Fahmi, H., & Benderdour, M. (2014). Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. Inflammation Research, 63(8), 691-701. doi:10.1007/s00011-014-0742-4
  21. Peng, H., Zhou, J., Liu, S., Hu, Q., Ming, J., & Qiu, B. (2010). Hyaluronic acid inhibits nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes in vitro. Inflammation Research, 59(7), 519-530. doi:10.1007/s00011-010-0156-x
  22. Altman, R., Manjoo, A., Fierlinger, A., Niazi, F., & Nicholls, M. (2015). The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskeletal Disorders, 16(1). doi:10.1186/s12891-015-0775-z
  23. De la Peña, E., Sala, S., Rovira, J. C., Schmidt, R. F., & Belmonte, C. (2002). Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity in vitro. Pain, 99(3), 501-508. doi:10.1016/s0304-3959(02)00260-9
  24. Forsey, R., Fisher, J., Thompson, J., Stone, M., Bell, C., & Ingham, E. (2006). The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model. Biomaterials, 27(26), 4581-4590. doi:10.1016/j.biomaterials.2006.04.018
  25. Lu, H., Sheu, M., Lin, Y., Lan, J., Chin, Y., Hsieh, M., … Chen, C. (2013). Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis. BMC Veterinary Research, 9(1), 68. doi:10.1186/1746-6148-9-68
  26. Prasadam, I., Crawford, R., & Xiao, Y. (2012). Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes – Possible Pathogenic Role in Osteoarthritis. The Journal of Rheumatology, 39(3), 621-634. doi:10.3899/jrheum.110777
  27. Hiraoka, N., Takahashi, K., Arai, Y., Honjo, K., Nakagawa, S., Tsuchida, S., … Kubo, T. (2009). 164 hyaluronan and intermittent hydrostatic pressure synergistically suppressed MMP-13 AND il-6 expressions in osteoblasts from OA subchondral bone. Osteoarthritis and Cartilage, 17, S97. doi:10.1016/s1063-4584(09)60186-2
  28. Ding, M., Christian Danielsen, C., & Hvid, I. (2005). Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Bone, 36(3), 489-501. doi:10.1016/j.bone.2004.12.010
  29. Piuzzi, N. S., Midura, R. J., Muschler, G. F., & Hascall, V. C. (2018). Intra-articular hyaluronan injections for the treatment of osteoarthritis: perspective for the mechanism of action. Therapeutic Advances in Musculoskeletal Disease, 10(2), 55-57. doi:10.1177/1759720x17752038
  30. Bagga, H., Burkhardt, D., Sambrook, P., & March, L. (2006). Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. Journal of Rheumatology, 33, 946-950.
  31. Migliore, A., Giovannangeli, F., Granata, M., & Laganà, B. (2010). Hylan G-F 20: Review of its Safety and Efficacy in the Management of Joint Pain in Osteoarthritis. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 3, 117954411000300. doi:10.1177/117954411000300001
  32. Raman, R., Dutta, A., Day, N., Sharma, H., Shaw, C., & Johnson, G. (2008). Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee — A prospective randomized clinical trial. The Knee, 15(4), 318-324. doi:10.1016/j.knee.2008.02.012
  33. Gigis, I., Fotiadis, E., Nenopoulos, A., Tsitas, K., & Hatzokos, I. (2016). Comparison of two different molecular weight intra-articular injections of hyaluronic acid for the treatment of knee osteoarthritis. Hippokratia, 20(1), 26–31.
  34. Miltner, O., Schneider, U., Siebert, C., Niedhart, C., & Niethard, F. (2002). Efficacy of intraarticular hyaluronic acid in patients with osteoarthritis—a prospective clinical trial. Osteoarthritis and Cartilage, 10(9), 680-686. doi:10.1053/joca.2002.0815
  35. Vaskova, N. V., & Lesniak, O. M. (2014). Preparaty gialuronovoy kisloty v lechenii osteoartroza kolennykh sustavov [Hyaluronic acid in the treatment of knee osteoarthritis]. Rossiyskiy semeynyy vrach, 18(3), 29-34. (in Russian).
  36. Dougados, M. (2000). Sodium hyaluronate therapy in osteoarthritis: Arguments for a potential beneficial structural effect.Seminars in Arthritis and Rheumatism, 30(2), 19-25. doi:10.1053/sarh.2000.0246
  37. Bannuru, R. R., Schmid, C. H., Kent, D. M., Vaysbrot, E. E., Wong, J. B., & McAlindon, T. E. (2015). Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Annals of Internal Medicine, 162, 46–54. doi: 10.7326/M14-1231
  38. Miller, L., Strand, V., McIntyre, L., Beach, W., & Block, J. (2015). Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta-analysis of randomized, saline-controlled trials. Journal of Pain Research, 217. doi:10.2147/jpr.s83076
  39. Bannuru, R. R., Natov, N. S., Dasi, U. R., Schmid, C. H., & McAlindon, T. E. (2011). Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis – meta-analysis. Osteoarthritis Cartilage, 19 (6), 611–619. doi: 10.1016/j.joca.2010.09.014
  40. Bannuru, R. R., Natov, N. S., Obadan, I. E., Price, L. L., Schmid, C. H., & McAlindon, T. E. (2009). Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Arthritis & Rheumatism, 61(12), 1704-1711. doi:10.1002/art.24925
  41. Campbell, K. A., Erickson, B. J., Saltzman, B. M., Mascarenhas, R., Bach, B. R., Cole, B. J., & Verma, N. N. (2015). Is Local Viscosupplementation Injection Clinically Superior to Other Therapies in the Treatment of Osteoarthritis of the Knee: A Systematic Review of Overlapping Meta-analyses. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 31(10), 2036-2045.e14. doi:10.1016/j.arthro.2015.03.030
  42. Rutjes, A. W., Juni, P., da Costa, B. R., Trelle, S., Nüesch, E., & Reichenbach, S. (2012). Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Annals of Internal Medicine, 157 (3), 180–191.
  43. Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product differences in intra-articular hyaluronic acids for osteoarthritis of the knee. The American Journal of Sports Medicine, 44 (8), 2158-2165. doi: 10.1177/0363546515609599
  44. Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system. Seminars in Arthritis and Rheumatism, 31(1), 58-68. doi:10.1053/sarh.2000.24874
  45. McAlindon, T. E., LaValley, M. P., Gulin, J. P., & Felson, D. T. (2000). Glucosamine and Chondroitin for Treatment of Osteoarthritis. JAMA, 283(11), 1469. doi:10.1001/jama.283.11.1469
  46. Anikin, S. G., & Alekseeva, L. I. (2012). Khondroitina sul'fat: mekhanizmy deystviya, effektivnost' i bezopasnost' pri terapii osteoartroza [Chondroitin sulfate: mechanisms of action, efficacy and safety in the treatment of osteoarthritis]. Sovremennaya revmatologiya, 3, 78-82. (in Russian)
  47. Shuba, N. M., Voronova T. D., & Krylova, A. S. (2013). Vybor strukturno-modifitsiruyushchikh i protivovospalitel'nykh preparatov u patsiyentov s osteoartrozom [The choice of structural-modifying and anti-inflammatory drugs in patients with osteoarthritis]. Ukrayinskyy revmatolohichnyy zhurnal, 2 (52), 67-73. (in Russian)
  48. Hochberg, M. (2010). Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis and Cartilage, 18, S28-S31. doi:10.1016/j.joca.2010.02.016
  49. Tosun, H. B., Gürger, M., Gümüştaş, S. A., Uludag, A., Üçer, Ö., Serbest, S., & Çelik, S. (2017). The effect of sodium hyaluronate–chondroitin sulfate combined solution on cartilage formation in osteochondral defects of the rabbit knee: an experimental study. Therapeutics and Clinical Risk Management, 13, 523-532. doi:10.2147/tcrm.s133635
  50. Rivera, F., Bertignone, L., Grandi, G., Camisassa, R., Comaschi, G., Trentini, D., … Fortina, G. (2016). Effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study. Journal of Orthopaedics and Traumatology, 17(1), 27-33. doi:10.1007/s10195-015-0388-1
  51. Udovika, M. I., Zhiliaev. E. V., & Anoshenkova, O. N. (2017). Effektivnost lokalnykh inyektsiy gialuronata natriya v terapii zabolevaniy myagkikh okolosustavnykh tkaney [Effectiveness of local injections of sodium hyaluronate in the therapy of diseases of soft periarticular tissues]. Poliklinila, 2, 98–104. (in Russian)
  52. Gorelick, L., Gorelick, A. R., Saab, A., Ram, E., & Robinson, D. (2015). Lateral epicondylitis injection therapy: a safety and efficacy analysis of hyaluronate versus corticosteroid injections. Advanced Techniques in Biology & Medicine 3:130. doi:10.4172/2379- 1764.1000130
  53. Khan, I. U., Awan, A. S., Khan, A. S., Marwat, I., & Meraj, M. (2018). Efficacy of a single-injection sodium hyaluronate treatment in lateral epicondylitis. Journal of Ayub Medical College Abbottabad Pakistan, 30 (1), 85-89.
  54. Noble, P. W., Liang, J., & Jiang, D. (2011). Hyaluronan as an immune regulator in human diseases. Physiological Reviews, 91(1), 221–264. http://doi.org/10.1152/physrev.00052.2009

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Vyrva, O., & Ashukina, N. (2023). Hyaluronic acid drugs in the treatment of joint pathology (literature review). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 117–124. https://doi.org/10.15674/0030-598720181117-124

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No. 1 (2018)

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