Cytokine level in blood serum of patients with osteoarthrosis

Authors

  • Volodymyr Filipenko
  • Frieda Leontyeva
  • Dmytro Morozenko
  • Iryna Korzh

DOI:

https://doi.org/10.15674/0030-59872012352-55

Keywords:

ostearthrosis, cytokine, patogenesis, diagnostics

Abstract

The article examines pathogenetic and diagnostic roles of the following cytokines in osteoarthrosis of large joints: interleukin 1 beta (IL-1β), interleukin 1RA (IL-1RA), interleukin 4 (IL-4), interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-α). It was revealed that levels of IL-1β and IL-6 increased from osteoarthrosis stages I-II to III-VI. IL-1RA concentration in patients’ blood at stages III-VI was lower versus I-II, IL-4 being higher only at stages III-IV of the disease, while TNF-α remained within normal values. Such changes of interleukin content in blood serum of patients with osteoarthrosis demonstrated severe immunological disturbances in their organism. A correlation between cytokine production levels at different stages of osteoarthrosis is indicative of the development of a natural induction of an acute inflammatory process in joints.

References

  1. Спектр провоспалительных цитокинов в сыворотке крови и синовиальной жидкости тазобедренного сустава при деформирующем коксартрозе / С. О. Давыдов, А. В. Олейниченко, В. А. Шильников и др. // Бюллетень СО РАМН. — 2003. — № 4 (110). — С. 63–66.
  2. Sun H. B. Mechanical loading, cartilage degradation, and arthritis / H. B. Sun // Ann. N. Y. Acad. Sci. — 2010. — №1211. — P. 37–50.
  3. Клековкина Е. В. Медиаторы иммунного воспаления в крови и синовиальной жидкости у больных остеоатрозом и ревматоидным артритом / Е. В. Клековкина, Б. Ф. Немцов // Цитокины и воспаление. — 2006. — Т. 5, № 3. — С. 49–54.
  4. Идиопатический остеоартроз коленного сустава І–ІІ стадии: иммунологические аспекты / Н. В. Сазонова, М. В. Чепелева, Е. А. Волокитина и др. // Травматология и ортопедия России. — 2008. — № 3 (49). — С. 11–14.
  5. Role of interleukine-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage / M. Kobayashi et al. // Arthritis Rheum. — 2005. — Vol. 52, № 1. — P. 128–135.
  6. Закономерности и механизмы формирования измененной иммунологической резистентности у больных с диспластическим коксартрозом / Л. А. Дмитриева, Е. Ю. Коршунова, В. В. Малышев // Бюллетень ВСНЦ СО РАМН. — 2006. — № 4 (50). — С. 70–76.
  7. Про- и противовоспалительные цитокины и компоненты экстрацеллюлярного матрикса суставного хряща у больных с разными стадиями посттравматического деформирующего артроза суставов нижней конечности / А. Д. Ахметжан, З. А. Богоутдинов, И. А. Болотова и др. // Вестник новых медицинских технологий. — 2009. — Т. 16, № 2. — С. 118.
  8. Алексеенко Е. Ю. Оценка маркеров воспаления и показателей оксидативного стресса у больных остеоартрозом в сочетании с артериальной гипертензией / Е. Ю. Алексеенко, А. В. Говорин // Сибирский медицинский журнал. — 2011. — Т. 26, № 1. — С. 54–58.
  9. Proinflammatory cytokine levels in patients with depressed left 1ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD) / G. Torre & Amione, S. Kapadia, C. Benedict [et al.] // J. Am. Coll. Cardiol. — 1996. — Vol. 27, № 5. — P. 1201–1206.

Downloads

How to Cite

Filipenko, V., Leontyeva, F., Morozenko, D., & Korzh, I. (2012). Cytokine level in blood serum of patients with osteoarthrosis. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 52–55. https://doi.org/10.15674/0030-59872012352-55

Issue

No. 3 (2012)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2014 Volodymyr Filipenko, Frieda Leontyeva, Dmytro Morozenko, Iryna Korzh

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).