The part played by a fibrin clot and mechanical stresses in it in the process of the primary bone regenerate formation in bone fractures

Authors

DOI:

https://doi.org/10.15674/0030-59872010322-27

Keywords:

diaphyseal fracture, fibrin clots, bone repair

Abstract

The research dealt with the study of topographic-structural peculiarities of fibrin clots and the reparative process during 2–6 days after a bone fracture with use of techniques of sonography and histomorphology. The study involved 35 casualties (adults and children) with diaphyseal fractures of their extremities, who underwent open reposition of fragments. The formation of fibrin clots was found out on the surface of injured tissues, which contained a considerable amount of blood vessels: in the area between fragments, over the intraosteal myeloid tissue and in the peripheral region. The blood fibrin clots, which formed around the fragments, were the primary morphobiological substrate; the latter served, beginning from the first days after the injury, as the basis for processes of vascularization, as well as migration and proliferation of cells of the fibroblastic and osteoblastic differons. No tissue regeneration processes in the areas of localization of the liquid component of haematomata were revealed.

References

  1. Зайченко И. Л. Элементы к построению управления развитием регенеративного процесса костной ткани и вообще тканей [Текст] / И.Л. Зайченко. — Львов, 1958. — 236 с.
  2. Корж А. А. Репаративная регенерация кости [Текст] / А. А. Корж, А. М. Белоус, Е. Я. Панков. — М.: Медицина, 1972. — 229 с.
  3. Корж Н. А. Репаративная регенерация кости: современный взгляд на проблему. Методы тканевой терапии и генной инженерии [Текст] / Н. А. Корж, Н. В. Дедух, Н. А. Ашукина // Ортопед. травматол. — 2006. — № 3. — С. 93–99.
  4. Kромпехер С. Местный тканевой метаболизм биологические особенности регенерата кости. Механизмы регенерации костной ткани [Текст]: пер. с англ. А.М. Белоусова, Е.Я. Панкова. — М., Медицина, 1971. — 294 с.
  5. Ангиогенез. Образование, рост и развитие кровеносных сосудов [Текст] / В. В. Куприянов, В. А. Миронов, А. Л. Миронов, О. Ю. Гурина. — М., НИО «Квартет», 1993. — 170 с.
  6. Маркс В. О. Заживление закрытого перелома трубчатой кости у человека и экспериментальных животных [Текст]: дис. … докт. мед. наук / Маркс Василий Оскарович. — Харьков, 1949. — 692 с.
  7. Маркс В. О. Заживление закрытого перелома кости [Текст] / В. О. Маркс. — Минск, Изд-во Академии Наук БССР, 1962. — 275 с.
  8. Физиология человека [Текст]; под ред. чл.-кор. АМН СССР Г. И. Косицкого, [Изд-е третье, перераб. и доп.]. — М., Медицина, 1985.
  9. Шиффман Фред Дж. Патофизиология крови [Текст]; пер. с англ. под ред. Е. Б. Жибурта, Ю. Н. Токарева / под общ. ред. акад. Ю. В. Натогина. — СПб., Невский диалект, 2001. — 444 с.
  10. Фриденштейн А. Я. Индукция костной ткани и остеогенные клетки предшественники [Текст] / А. Я. Фриденштейн, К. С. Лалыкина. — М., Медицина, 1973. — 221 с.
  11. Хмельницкий О. К. Об остеопластических свойствах фибрина излившейся крови [Текст] / О. К. Хмельницкий: труды Ленинградского ин-та травматологии и ортопедии, 1956. — № 5. — С. 64.
  12. Шевцов В. И. Ультраструктурные особенности ангиогенеза при заживлении переломов [Текст] / В. И. Шевцов, Ю. М. Ирьянов // Гений ортопедии. — 1999. — № 4. — С. 13–18.
  13. Эльяшев А. И. Регенерация костной ткани и способы ее стимуляции [Текст] / А. И. Эльяшев. — Ленинград, 1939. — 127 с.
  14. Paletts G. A. The repair of osteochopndral defects using an exogenous fibrin clot [Text] / G. A. Paletts, C. P. Amocrky, R. F. Warwen // Am. Journal of Sport Medicine. — 1992. — Vol. 20, № 6. — P. 725–731.
  15. Kanczler J. M. Osteogenesis and Osteogenesis: the potential for engineering bone [Text] / J. M. Kanczler, R. O. Oreffo // European Cells and Materials. — 2008. — Vol. 15. — P. 110–114.

Downloads

How to Cite

Popsuishapka, O., Litvishko, V., Ashukina, N., & Pidgaiska, O. (2010). The part played by a fibrin clot and mechanical stresses in it in the process of the primary bone regenerate formation in bone fractures. ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (3), 22–27. https://doi.org/10.15674/0030-59872010322-27

Issue

No. 3 (2010)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2014 Olexey Popsuishapka, Valery Litvishko, Natalya Ashukina, Olga Podgayskaya

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors retain the right of authorship of their manuscript and pass the journal the right of the first publication of this article, which automatically become available from the date of publication under the terms of Creative Commons Attribution License, which allows others to freely distribute the published manuscript with mandatory linking to authors of the original research and the first publication of this one in this journal.

Authors have the right to enter into a separate supplemental agreement on the additional non-exclusive distribution of manuscript in the form in which it was published by the journal (i.e. to put work in electronic storage of an institution or publish as a part of the book) while maintaining the reference to the first publication of the manuscript in this journal.

The editorial policy of the journal allows authors and encourages manuscript accommodation online (i.e. in storage of an institution or on the personal websites) as before submission of the manuscript to the editorial office, and during its editorial processing because it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the published manuscript citation (see The Effect of Open Access).