Strontium ranelate: the mechanism of its effect on the bone, prevention and treatment of fractures (a review of literature)

Authors

DOI:

https://doi.org/10.15674/0030-598720131104-112

Keywords:

strontium ranelate, fractures, treatment

Abstract

On the basis of literature data and their own studies, the authors present information about strontium ranelate. There is voluminous evidential base that strontium ranelate has a double mechanism of action in the influence on the process of bone remodelling – inhibition of processes of resorption and stimulation of osteogenesis. The key mechanism of the latter consists in stimulation of proliferation and differentiation of osteoblast precursor cells by the drug, increase of their viability and metabolism, directed to building of the bone tissue matrix and bone mineralization, these items being the basic link in the prevention of osteoporotic fractures and bone regeneration in fractures. The authors describe certain mechanisms of cell resorption and the role of programmed osteoblastic diferentiation cells in activation of osteoclustogenesis by means of the RANK/RANKL/OPG cytokine system, which is the key molecular target for the double effect of strontium ranelate on bone cells. For the first time in the assessment of osteotrophic preparations, attention is paid to the influence of strontium ranelate on osteocytes and its positive role in the differentiation of osteoblasts into osteocytes is shown. The efficacy of the drug is proved by a reduction of the absolute risk of development of vertebral and peripheral fractures as well as in the optimization of reparative osteogenesis, thereby enabling doctors to approach the prophylaxis and treatment of osteoporotic fractures differentially in each particular case.

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How to Cite

Korzh, M., Dedukh, N., & Pobel, Y. (2013). Strontium ranelate: the mechanism of its effect on the bone, prevention and treatment of fractures (a review of literature). ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, (1), 104–112. https://doi.org/10.15674/0030-598720131104-112

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No. 1 (2013)

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DIGESTS AND REVIEWS

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Copyright (c) 2014 Mykola Korzh, Ninel Diedukh, Yevgeny Pobel

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