Alphacalcidol in bone regeneration

Mykola Korzh, Ninel Dedukh, Lidia Goridova, Yevgeny Pobel, Konstantin Romanenko, Yaroslav Doluda

Abstract


The article deals with results of an experimental study of animals with an injury of their femur, as well as it contains a generalized analysis of results of treatment of 35 patients, who suffered from affected reparative osteogenesis, with alphacalcidol (Alpha D3-Teva drug). It was found out that in the animals with modelled osteoporosis the drug stimulated bone formation in the injury area versus untreated rats. More proximally from the area of injury, a larger thickness and a greater number of trabeculae of bone, better osteointegration of the spongy bone with the compact one, and a less ratio between an eroded bone volume and that of trabeculae of bone versus the animals with modelled osteoporosis without any treatment were revealed. In conditions of the treatment of the patients with alphacalcidol a positive effect was achieved in 94 % of cases. No progression of osteopoenic syndrome in the skeletal segment above the area of injury was detected. A higher mineral density of the bone tissue was observed. Tolerance to the drug was regarded as good on the basis of an objective examination and questioning of the patients.

Keywords


fracture; bone mineral density; experimental animals; patients; alfacalcidol

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DOI: https://doi.org/10.15674/0030-59872013173-83

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