Dynamics of biochemical and immunological parameters in patients with malignant and benign tumors of the thoracic and lumbar spine

Mykola Korzh, Volodymyr Radchenko, Frieda Leontyeva, Volodymyr Kutsenko, Bogdan Shevtsov, Andrey Popov


The problem of early diagnosis of neoplasm of the spine remains relevant. One of the most sensitive diagnostic tests for bone tu­mors is the determination of biochemical and immunochemi­cal markers in the blood serum of patients.

Objective: to study biochemical markers and blood serum cytokines that reflect the state of different types of metabolism and the dynamics of the inflammatory reaction in patients with primary tumors of the thoracic and lumbar spine and metastases of extra vertebral tumors to the spine.

Methods: blood and immunochemical study of blood serum of 45 patients with primary benign and malignant tumors of the thoracic and lumbar spine of different histological structure, as well as metastases in the vertebral bodies with carcinoma of the extravertebral localization and 11 conditionally healthy middle-aged people. The dynamics of biochemical parameters of carbohydrate, protein and lipid metabolism, as well as serum levels of anti-inflammatory inter­leukins IL-1β and IL-6, and procalcitonin were evaluated.

Re­sults: a significantly higher content of IL-1β, IL-6 and procalci­tonin in the blood serum of patients with metastases of different carcinomas in the vertebrae and primary malignant tumors was found in comparison with benign tumors. A significantly higher level of alkaline phosphatase activity was established in patients with primary malignant neoplasms of the thoracic and lumbar spine and metastases in the vertebrae.

Conclusions: variations in the content of IL-1β, IL-6, and procalcitonin may indicate the stimulation of the inflammatory focus around the tumor and largely reflect their problastic effect. Activation of alkaline phosphatase in patients with primary malignant neoplasms and metastases in the vertebra is probably a confirmation of com­pensatory activation of osteosynthesis in response to onco­genic osteolysis.


primary spinal tumors; metastases in the vertebrae; biochemical and immunochemical markers


Sergeeva N, Teplyakov V, Derzhavin V. Biochemical markers of bone remodeling in oncology. Onkologiya. Zhurnal imeni P.A. Gertsena.2012;2:103–8. (in Russian)

Voronovich IR, Pashkevich LA, Vsesojuz TrV. Modern principles of treatment of complicated spinal injury. Congress of traumatologists and orthopedists. Moscow: 1990;1:195-200. (in Russian)

Ermakova IР. Exchange bone biochemical markers and their clinical application. Laboratoriya. 2001;(3):3-5. (in Russian)

Kamyshnikov VS. Clinical and biochemical laboratory diagnostics. Handbook. 2nd ed. Minsk: Interpresservis, 2003. 463 p. (in Russian)

Lyubimov NV, Kushlinskij NI. Bone remodeling markers: General views and clinical significance in skeletal lesions in cancer patients. Problems of Oncology.2001;47(1):18-33. (in Russian)

Fіlіpenko VA. Vertebroectomy in the treatment of destructive diseases and complicated spine injuries. Abstract of thesis for Doctor of Medical Sci. Kharkiv, 1995. 46 p. (in Ukrainian)

Gelb DE, Bridwell KH. Bening tumors of the spine. The Textbook of spinal surgery. Eds. K. H. Bridwell, R. L. Dewald. 2nd edition. Philadelphia: Lippincott Williams & Wilkins, 1997. рр. 1959–78.

Sama AA, Girardi FP, Cammisa FP. Spinal tumors. 2016. Available from: http://emedicine. medscape.com/article/1267223-overview#a5.

Halleen JM, Alatalo SL, Janckila AJ, Woitge HW, Seibel MJ, Väänänen HK. Serum tartrate-resistant acid phosphatase is a specific and sensitive marker of bone resorption. Clin Chem. 2001;47(3):597–600.

DOI: https://doi.org/10.15674/0030-59872017230-34


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